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Biomedical subjects

M Hashimoto

Publications and source records attributed to M Hashimoto.

At least 1,135 records · Page 63Linked to original sources
PubMed1982

[Immunochemotherapy of resectable lung cancer--a preliminary study on a comparison of the control, levamisole, and OK-432].

We conducted a prospectively controlled study of adjuvant immunochemotherapy for resectable lung cancer in 37 cases of the control group, in 34 cases of levamisole group and in 40 cases of OK-432 group. No significant difference was noted in patient characteristics of age, sex, histological type, stage, cure rate, etc. The survival rates were calculated by Kaplan and Meier method. Survival curves were measured by generalized Wilcoxon test and Cox-Mantel test. When the levamisole group and the control group were compared in terms of survival rate, a significant increase of survival curves of patients treated with levamisole was observed in surgicopathological stage III + IV and relative curative operation groups (p less than 0.05). The survival rate of levamisole group was higher than that of OK-432 group in patients of surgicopathological stage III and III + IV (p less than 0.05). There was no statistically significant difference between OK-432 group and the control group, when in survival rates.

Adult↗
PubMed1982

The role of the psychiatrist in the general hospital. I. Investigation and analysis pertaining the status of the psychiatrist in the general hospital.

Data for this study consisted of answers to a series of questions on the image of clinical psychiatry addressed to all the non-ppsychiatric clinicians in the Tokai University Hospital, and all the referral sheets for psychiatric consultation from non-psychiatric departments of the hospital for about 2 years since the beginning of the hospital's operation. The reaction was analysed as follows: (1) psychiatric services were requested for the reasons of "no organic abnormality" or for "differential diagnosis" in 59.4% of total referrals, (2) as many as 37.9% of non-psychiatric clinicians made no attempt to refer the patient to psychiatrists in spite of their recognition that these patients apparently needed psychiatric treatment, (3) trouble in doctor-patient relationship, if it was the real reason for asking for sychiatric services, was frequently not mentioned in the referral sheet, and (4) the reason for psychiatric consultation was rarely told clearly to the patient. On the basis of the above-mentioned findings, the role of the psychiatrist in the general hospital setting was reexamined.

Attitude to Health↗
PubMed1982

[Radiographical and pathohistological study of the femoral neck fractures].

Femoral neck fractures are of great interest for challenging several problems to indicate surgical procedures. Even though ages and general or local conditions of the patient, and types of fracture or some other influencing factors are sufficiently taken into consideration, it is very difficult to foresee the fate of femoral head on the radiogram at the time of injury. This viability of fractured femoral head is the most important factor to choose the method of treatment, but no adequate method of assessing the viability has been established. One hundred and twelve femoral heads removed in the course of endo-prosthetic replacement were examined radiologically and histopathologically to study the factors influencing to the fate of fractured femoral heads. Histological findings of the femoral heads, in particular the extent of necrotic or revascuralized areas on the decalcified section stained with H-E, were compared with radiological findings such as the size or shape of the femoral head, the fracture line, the extent of displacement and osteoporosis or Singh's grade. Several factors which may influence the viability of the fractured femoral head have become clear. The site and direction of fracture line, extent of displacement and destruction of femoral head were thought to be important factors. Medial type of femoral neck fractures could be classified into four groups from a result of this study. They are less displaced, transcervical, crescent shape and severe displaced type. The first two may have a tendency to good revascuralization, and the last two groups to necrosis of the fractured head. This clinical classification is thought to be useful in the treatment of this fracture.

Aged↗
PubMed1982

The role of the psychiatrist in the general hospital--II. Psychiatric patients with somatic complaints.

In part I, one of the important roles of the psychiatrist in the general hospital was pointed out with respect to the management and treatment of psychiatric patients with somatic complaints (PPSC) referred from other nonpsychiatric departments of the hospital. Part II deals with the way in which a PPSC is brought to the psychiatrist, and the basic principles concerning the initial interview which is crucial to the management and treatment of such patients. The principles for the initial interview are to clarify: (1) the processes through which the patient came to the psychiatrist, (2) the patient's motivation for receiving psychiatric help, (3) the nature of his relationship to the physician, and (4) related anxiety, etc. Referral of the patient to psychiatric treatment should not be done in haste, but advice to the physician must be given on maintaining or improving his relationship with the patient. Advice on how patients should be introduced to psychiatric treatment is included here.

Adult↗
PubMed1981

Gas chromatographic determination of the hypoglycaemic agent gliclazide in plasma.

A gas chromatographic method has been developed that permits the accurate and specific determination of the hypoglycaemic agent gliclazide in plasma. Gliclazide is extracted with chloroform and, after clean-up, derivatized with diazomethane followed by heptafluorobutyric anhydride to form N-methyl-N'-heptafluorobutyrylgliclazide, which is assayed on a gas chromatograph equipped with a flame ionization detector, an electron-capture detector or a nitrogen-phosphorus sensitive detector. Accurate determinations are possible with flame ionization detection over a concentration range of 1--15 microgram/ml of gliclazide in plasma with a relative standard deviation of 5.2%. The minimum detectable concentration with electron-capture detection is 0.02 microgram per sample. Plasma levels of gliclazide in dogs following single oral administration (40 mg per dog) have also been determined.

Animals↗
PubMed1981

A silent period in sural muscle occurring prior to the voluntary forward inclination of the body.

A silent period lasting for 300-500 msec was observed in triceps surae muscle when the subject inclined forward from the normal standing. This silent period preceded 100 msec or more the beginning of the body inclination and was terminated by an abrupt refiring in the midst of the body swing. The silence was not preceded by the increase in activity of the sural muscle itself or any other leg muscles studied. H-reflex in soleus was strongly inhibited or disappeared during the silent period, indicating that the excitability of the spinal motoneurons was greatly decreased during this period. These findings suggest that the silent period was not induced by some reflex activity in the spinal cord, but was caused by the inhibitory activity based on a central program on the spinal motoneurons.

Adult↗
PubMed1981

Effects of thermal load on ion release of the rabbit vitreous body.

Ion-release of the rabbit vitreous body through a dialysis membrane against water was studied. To evaluate one of thermal changes in the vitreous properties, the vitreous was heated or cooled before dialysis. The average wet weight of the normal vitreous was 1.61 +/- 0.20 g and dry to wet weight ratio was 1.33 +/- 0.04%. The dry weight, sodium, potassium, and chloride concentrations of the vitreous were decreased as an exponential function curve by dialysis. A decreasing ratio was prominent in the heated vitreous, the frozen vitreous and the non-thermo-treated (control) vitreous in turn. Calcium and magnesium release from the rabbit vitreous body was slow and differences among the heated, frozen and non-thermo-treated vitreous bodies were not significant, suggesting some different capture-mechanisms between the monovalent and bivalent ions.

Animals↗
PubMed1981

Cytochemical localization of alkaline phosphatase in intestinal metaplasia of the human stomach.

Alkaline phosphatase in the brush border of areas of intestinal metaplasia of human stomach was studied cytochemically. All absorptive cells in the upper part of the villi of the duodenum had strong alkaline phosphatase activity but, in areas of intestinal metaplasia, the metaplastic glands consisted of alkaline phosphatase-positive and negative absorptive cells. Alkaline phosphatase activity was found in tall dense microvilli of absorptive cells in areas of intestinal metaplasia and in the duodenum. However, in some areas of metaplastic epithelium the activity was very weak in some tall dense microvilli of absorptive cells but strong in those of neighbouring absorptive cells. No alkaline phosphatase activity was found in short sparse microvilli of absorptive cells in areas of intestinal metaplasia. The difference in alkaline phosphatase activity in microvilli of different cells in areas of intestinal metaplasia, which is not seen in the duodenum, indicates abnormal morphological and enzymatic differentiation intestinal metaplasia.

Alkaline Phosphatase↗