Biomedical subjects

M Greenberg

Publications and source records attributed to M Greenberg.

At least 289 records · Page 16Linked to original sources

PubMed1977

Inhibition of platelet function with 2,3-dihydroxybenzoic acid.

2,3-Dihydroxybenzoic acid (2,3-DHB) inhibits the second wave of platelet aggregation release of serotonin, and malonaldehyde production. The effect is concentration dependent and reversible in vitro and in vivo. 50% inhibition of platelet aggregation induced in vitro with 70 micron adrenaline was obtained with 1.5 mM 2,3-DHB. Malonaldehyde production was inhibited by 50% with 0.4 mM 2,3-DHB. Serotonin release was 50% inhibited by 50% with 0.08 mm 2,3-DHB. Neither desferrioxamine nor various benzoic acid derivatives with iron-chelating properties showed the effect. Only benzoic acid derivatives with the potential to terminate free radical reactions through the formation of an ortho- or paraquinone structure inhibit the second wave of platelet aggregation. These studies support the concept that the second wave of platelet aggregation is mediated through free radical reactions.

Blood Platelets↗

PubMed1977

Fungal antigens as a source of sensitization and respiratory disease in Scottish maltworkers.

Mycological and serological studies were carried out as part of a survey of respiratory disease in Scottish maltworkers. 70% of stained sputum smears from 574 workers showed the presence of higher plant cells and/or myclelia, and the spores of common environmental fungi. Penicillium spp. (90%), Rhizopus stolonifer (48%) and yeasts (53%) were the dominant fungi in 699 sputum cultures, and showed a similar proportional distribution in 327 samples of grain, malt, culms and dusts from fifty-six maltings. 57% of 711 men were serologically positive for fungi, 22% for Aspergillus fumigatus, 20% for A. clavatus, 10% for A. niger, 16% for Cladosporium herbarum and over 3% for Rhizopus stolonifer, 6% of 132 men were positive for Penicillium cyclopium. No precipitating antibodies to antigens from Alternaria tenuis, Aureobasidium pullulans, Candida albicans, Geotrichum candidum, Rhodotorula glutinis or Trichoderma viride were detected in tests of forty sera. Sera from the 5.2% of men with symptoms of extrinsic allergic alveolitis showed increased reactivity to mycelial antigens from Aspergillus clavatus. The fungus was cultured from 21% of maltings, 7% of all environmental samples and from the sputa of 8% of maltworkers.

Alternaria↗

PubMed1976

Extrinsic allergic alveolitis in Scottish maltworkers.

In a survey of respiratory disease in the Scottish malting industry 5.2% of employees were found to have symptoms of extrinsic allergic alveolitis. In most cases the disease was mild and not associated with any serious respiratory disability. It was significantly less common where modern mechanical methods of malting were used. Mycological and serological studies suggested that it was usually caused by a type 3 allergic reaction to Aspergillus clavatus.

Allergens↗

PubMed1976

Initial evaluation of reduced fractionation in the irradiation of malignant epithelial tumors.

From July, 1971, through June, 1974, 170 patients underwent radiation therapy with reduced fractionation at the Milwaukee County General Hospital and the Wood Veterans Administration Hospital. One or two fractions per week were delivered for five to seven weeks to a total dose based on the tolerance of normal tissues predicted by the nominal standard dose (NSD) hypothesis of Ellis. Three groups of patients were selected from this heterogeneous population for detailed analysis--carcinomas of the skin, breast, and lung. The 72 patients evaluated provide useful data in regard to acute and subacute reactions. Short term assessment of local tumor control in relation to surrounding normal tissue response is similar to that with conventional fractionation for each of these malignant epithelial tumors.

Breast Neoplasms↗

PubMed1976

Parameters to consider in the selection and purchase of a freeze-drying system.

When considering the purchase of a freeze-dryer, the user must establish his own performance standards and particular requirements for the following reasons: 1. Large monetary investment required for the purchase, operation and maintenance of the equipment. 2. The expense and stability of the products to be freeze-dried. Some of the basic parameters that must be considered: 1. Product requirements, such as volumes, optimum temperature, and vacuum limits. 2. Facility restraints relating to the availability of space, and utilities. 3. Return on the capital investment (ROI) 4. Technical competence of operating and maintenance personnel. When the parameters are established, the buyer is prepared to purchase a freeze-dryer to best suit his needs. Precise cycle development, reliable hardware and personnel training, assure productivity and product quality.

Costs and Cost Analysis↗

PubMed1975

Iminodipeptiduria: a genetic defect in recycling collagen; a method for determining prolidase in erythrocytes.

A 39-month-old girl was found to have a genetic deficiency of prolidase. This enzyme specifically splits dipeptides with proline or hydroxyproline at the C-terminus. Absence of the enzyme leads to massive urinary excretion of iminodipeptides. Clinical symptoms include some that can be ascribed to collagen defects. Previously we had demonstrated that the efficient recycling of proline by the breakdown and resynthesis of collagen is a normal physiological process. The collagen defects in this condition could result from interference with the normal recycling of collagen.

Amino Acid Metabolism, Inborn Errors↗

PubMed1975