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Biomedical subjects

M Greenberg

Publications and source records attributed to M Greenberg.

At least 271 records · Page 15Linked to original sources

Female urethral diverticula: double-balloon catheter study.

A double-balloon catheter was used to evaluate the female urethra in 51 patients. Six different radiographic appearances were identified. Three of the categories are considered variants of normal. One of the categories consisted of eight patients with urethral diverticula. All showed large rounded or lobulated collections of contrast material which were adjacent to the urethra and which persisted on postvoid films. Other abnormalities should be closely correlated with the clinical findings to determine their significance. The diagnosis of urethral diverticulum may be missed, as physical examination and endoscopy can be negative. Therefore, the optimal method for identifying its presence and extent includes both a double-balloon catheter study and a voiding cystourethrogram.

Adult↗

Discordant anencephalus in a Pergonal-induced triplet pregnancy.

A patient with a triplet pregnancy had one infant affected by anencephalus. This pregnancy resulted from ovulation stimulation by gonadotropins. Several cases of association between anencephalus and induction of ovulation by clomiphene have been reported. The association with gonadotropins, however, has been reported only once. The event was prenatally diagnosed by ultrasound studies in the first and second trimesters. The association of anencephalus with ovulation stimulation is discussed briefly.

Adult↗

Recurrent environmentally triggered thrombophlebitis: a five-year follow-up.

Twenty disabled patients with recurrent intractable nontraumatic phlebitis were studied. The patients were divided into two groups and matched for age and severity. The control group was continued on their standard anticoagulant regime, bed rest and support hose. The other group was placed in an especially designed Environmental Control Unit (ECU) where all air, food and water could be controlled. These patients were taken off all medication and not fed until the leg pain and swelling disappeared, which was four to seven days. The patients then showed specific sensitivities to foods and ambient subthreshold doses of inhaled chemicals such as formaldehyde less than 0.2 ppm, phenol less than 0.0024 ppm, chlorine less than 0.33 ppm, petroleum alcohol less than 0.5 ppm and pesticide (2,4 DNP) less than 0.0134 ppm under controlled double-blind challenges. Eight out of 10 patients had their phlebitis reproduced in this manner. When in the symptom-free state, these patients were required to ride an exercycle at 150 kpm for one mile daily to demonstrate absence of phlebitis (none could walk across the room prior to examination). The five-year follow-up in the group showed two 48-hour episodes of phlebitis cleared by home bed rest and food abstenance. In contrast, the control group had more than 60 episodes of phlebitis at home and 41 episodes in the hospital. Medical costs in these comparable groups showed a differential of $20 per patient in the Environmental Control Unit treatment versus more than $20,000 per patient in the control group over the five-year follow-up.

Adult↗

Locally advanced adenocarcinoma of the endometrium: results of irradiation with and without subsequent hysterectomy.

From 1965 through 1977, 54 patients with locally advanced adenocarcinoma of the endometrium were treated at the Medical College of Wisconsin Affiliated Hospitals. According to the FIGO-AJC staging system, 39 had Stage II and 15 Stage III disease. Stage II was subdivided into II A-microscopic (28 patients) and II B-clinical (11 patients) involvement of the cervix. Patterns of failure were evaluated, viz. central pelvic, lateral pelvic, and distant. The results confirm an association of increasing grade with increasing stage. Disease-free survival rates at five years are better for Stage II (78%) than Stage III (34%), but are no different for Stages II A (77%) and II B (81%). Pattern of failure and disease-free survival data support the combined irradiation-surgical approach over irradiation alone. Central pelvic failures are reduced by subsequent hysterectomy (6% vs. 20%). Lateral pelvic failures are less frequent when the dose of external pelvic irradiation is 5000+ rads/5-6 weeks compared to less than 5000 rads (4% vs. 20%). In Stage II (corpus et collum) the prognosis is better with preoperative irradiation and abdominal hysterectomy than with irradiation alone (89% vs. 63%). Whenever possible, patients with Stage III disease should be offered irradiation and hysterectomy.

Adenocarcinoma↗

A time-series comparison of cancer mortality rates in the New Jersey-New York-Philadelphia metropolitan region and the remainder of the United States, 1950--1969.

Cancer mortality trends from 1950 to 1968 were studied for the New Jersey-New York-Philadelphia metropolitan region and the remainder of the United States for 65 age- sex- and race-standardized causes. Usuing total population, age-adjusted rates for the years 1950--1954, 1955--1959, 1960--1964 and 1965--1969, the findings show a strong tendency for the region and the remainder of the nation to be moving toward similar mortality patterns. White and nonwhite male rates in the remainder of the nation are rapidly catching up to the study region's rates. Female rates are converging, although less rapidly.

Black or African American↗

The ultrasonographic diagnosis of cholecystitis and cholelithiasis in children.

Cholecystitis and cholelithiasis should be considered in the differential diagnosis of abdominal pain in children. Ultrasonography should be a primary screening test because it allows rapid evaluation of the gallbladder and identifies other possible causes of the symptomatology. The presence of a thickened gallbladder wall, cholelithiasis, or a nonvisualized gallbladder indicates gallbladder disease. Since acalculous cholecystitis is more common in children than it is in adults, it is particularly important to examine the gallbladder wall carefully for evidence of thickening.

Adolescent↗

Pulmonary nodules: detection in 1 and 2 cm full lung linear tomography.

Pulmonary nodule detection was evaluated in full lung linear tomography at 1 and 2 cm intervals. Three radiologists independently reviewed 1 and 2 tomograms on 26 patients with 39 pulmonary nodules. Decisions made in each case included: (1) no nodule; (2) definite nodule(s); and (3) suspect nodule(s). The presence of nodules was determined by surgery, radiographic follow-up, or observer consensus. A significantly greater number of nodules was detected by all reviewers on the 1 cm tomograms. Of the 39 nodules, 72%-97% were detected as definite and 82%-100% were identified as definite or suspect. Factors relating to nodule detectability and observer performance are discussed. It is recommended that full lung linear tomography be performed at 1 cm intervals.

Evaluation Studies as Topic↗

The effects of rubidium on mammary tumour growth in C57 blk/6J mice.

A high pH therapy for cancer arrived at theoretically was tested in mice by feeding them rubidium carbonate. Tumours were transplanted in the abdomen of mice and allowed to grow for 8 days. The mice were then divided into two groups. The control group was continued on conventional mouse chow. The test group, in addition to the mouse chow, was force-fed 1.11 mg of rubidium carbonate dissolved in distilled water. At the end of 13 more days the tumours in the controls had grown to a large size so all the mice were sacrificed. The tumours were then removed and weighed. The tumours in the test animals weighed essentially one eleventh of those in the controls. In addition the test animals were showing no adverse effects from the cancers. The probability that this marked difference in tumour size could have come about by chance is exceedingly small.

Animals↗

The trauma room.

Explore the source record for details and available documents.

Equipment and Supplies, Hospital↗

Dose-time relationships and the local control of small cell carcinoma of the lung.

Since 1971, 66 patients with small cell carcinoma of the lung--32 with limited and 34 with disseminated disease--have received irradiation to the primary tumor. There were 20 local failures, 90% of which were apparent within 30 weeks of the start of irradiation. Patients were treated with local irradiation only (32), irradiation plus combination chemotherapy (25), or local plus total body irradiation (9). With local irradiation alone, tumor control increased with increasing biologic dose. When chemotherapy or total body irradiation was added, doses of irradiation that were otherwise insufficient for local control proved to be effective.

Adult↗

Laryngeal incompetence during experimental "relative analgesia" using 50% nitrous oxide in oxygen. A preliminary report.

Ten healthy adult volunteers inhaled 50% nitrous oxide in oxygen while dental treatment was simulated for a period of 30 min. During this time 15 ml of radio-opaque dye was placed at the back of the tongue. A similar control study was performed 1 week later, the subjects inhaling pure oxygen without nitrous oxide. X-ray examination revealed that two of the 10 volunteers had aspirated dye while breathing nitrous oxide and oxygen, but no aspiration was apparent in the control study.

Adolescent↗