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Biomedical subjects

M Gordon

Publications and source records attributed to M Gordon.

At least 361 records · Page 20Linked to original sources
PubMed1982

Central corneal endothelial cell density and central corneal thickness in ocular hypertension and primary open-angle glaucoma.

In order to assess the effect of increased intraocular pressure on the corneal endothelium, we classified 254 patients into four groups: Group 1, those with normal intraocular pressures; Group 2, those with untreated ocular hypertension; Group 3, those with treated ocular hypertension; and Group 4, those with primary open-angle glaucoma. One eye of each patient underwent specular microscopy and pachymetry. The eyes in the four groups did not differ significantly as to central corneal endothelial cell density or central corneal thickness. These measurements were not related to sex, race, or intraocular pressure (P greater than .12 in all cases). Increasing age was associated with a decrease in central corneal endothelial cell density (P = .0001), but was not associated with a change in central corneal thickness (P = .22). There was no significant relationship between the use of topical ocular hypotensive medications and central corneal endothelial cell density (P = .38) or central corneal thickness (P = .07) in patients with ocular hypertension or primary open-angle glaucoma. Neither uncomplicated peripheral iridectomy nor trabeculectomy produced significant changes when preoperative measurements were compared to measurements made 12 weeks postoperatively (P greater than .30 in all cases). Two eyes with flat anterior chambers following trabeculectomy had substantial decreases in central corneal endothelial cell density.

Adult↗
PubMed1982

Psychosocial aspects of constitutional short stature: social competence, behavior problems, self-esteem, and family functioning.

To determine the psychosocial effects of short stature, we administered a battery of psychologic tests to 24 children (ages 6 to 12 years) with constitutional short stature. Their results were compared to those of a group of 23 healthy children with normal stature matched for age, IQ, sex, and socioeconomic status. The short children had significantly higher scores on parental ratings of behavioral difficulties, especially somatic complaints, social withdrawal, and schizoidal tendencies. There were also indications of impaired self-concept as expressed by feelings of unpopularity and dissatisfaction. Parental responses suggested a tendency to set less clear limits on behavior, but not necessarily toward overprotectiveness. Parents of short children also gave responses indicating poorer communication and cooperation among family members. In contrast to recent studies of growth hormone-deficient children, in which no maladjustment surfaced, these results indicate that children with constitutional delay have characteristic behavioral difficulties.

Body Height↗
PubMed1982

Hyperparathyroidism due to a cystic parathyroid adenoma after irradiation of the neck.

A 48-year-old female with hypercalcaemia diagnosed 3 years prior to admission is described. The patient underwent x-ray therapy of the neck for keloid scars 35 years prior to the diagnosis of hypercalcaemia. The hypercalcaemia was found to be the result of primary hyperparathyroidism. A cystic parathyroid adenoma was identified during surgery and was, on microscopic examination, composed of oxyphil cells rich in mitochondria. The cystic fluid contained 360 times higher C-terminal PTH than peripheral serum and almost 4000 times higher PTH as intact 1-84 amino acid residue species. We concluded that previous X-ray irradiation was related to the pathogenesis of the patient's parathyroid adenoma. The mild nature of the patient's hyperparathyroidism was possibly related to the composition of the tumour of oxyphil cells, known to be a poorly functioning variant of the parathyroid cell. Since parathyroid 'cysts' are obviously necrotic parathyroid adenomas, aspiration of the cysts alone cannot be expected to be curative and, therefore, it is recommended to treat cystic parathyroid adenomas by surgical extirpation.

Adenoma↗
PubMed1982

An evaluation of falls, syncope, and dizziness by prolonged ambulatory cardiographic monitoring in a geriatric institutional setting.

Fifty-nine patients living in a geriatric residential setting underwent prolonged ambulatory cardiographic monitoring with the Holter monitor (AHM) as part of an investigation of falls, dizziness, and syncope. In 16 instances, cardiac arrhythmias were a contributing factor; in 12, the diagnostic AHM recordings were associated with unrevealing standard electrocardiographic (ECG) tracings. In 12 patients who had fallen, cardiac arrhythmias played a contributing role, but in only two of these cases was the ECG diagnostic. The value of the AHM for use in managing elderly patients, whose cardiac complaints may be vague, and especially in managing those who have sustained falls, is emphasized.

Aged↗
PubMed1982

Central placement of Bender figure a by clinic-referred and non-referred children.

To test the validity of clinical reports suggesting the diagnostic significance of central placement of the first Bender-Gestalt design, the protocols of 58 clinic-referred children (ages 6 to 12 yr.) and 58 non-referred children matched for age and WISC-R Full Scale IQ were examined. As predicted, central placement occurred with greater frequency in the clinic group, but its clinical utility is unclear.

Bender-Gestalt Test↗
PubMed1982

Detecting excessive drinking among admissions to a general hospital.

A questionnaire combining items on alcohol consumption with the four CAGE questions was used by 27 housemen to detect abnormal drinking among 520 patients of all specialties admitted to a general hospital. 15.6--23.2% of patients were classified as abnormal drinkers with the largest proportions occurring among the emergency surgical, orthopaedic, psychiatric and medical patients. 95% of the abnormal drinkers were detected by the questions on consumption alone, while 22 of the 28 patients who were identified by both the consumption and CAGE questions had been admitted as a direct result of alcohol abuse. With the aid of simple questionnaire and some encouragement, junior medical staff can become quite adept at detecting abnormal drinkers in the course of their routine practice.

Alcoholism↗
PubMed1982

Falls in the elderly: more common, more dangerous.

Eye, ear, endocrine, neurologic, arrhythmic, and other disorders can be underlying causes of falls. For this reason, a thorough history following a fall is essential. To document an arrhythmia as the cause of a fall, the best instrument to use is the Holter ambulatory monitor. A 24-hour tracing is standard.

Accidents↗
PubMed1982

Part I. Patient administration of eyedrops: interview.

Interviews of 141 patients were conducted to determine their use of eyedrops. This study indicates a need to improve patient instruction concerning drug compliance and proper time scheduling of eyedrop treatments.

Adult↗
PubMed1981

Keratoconjunctivitis and soft contact lens solutions.

Three patients with soft contact lenses had acute onset of a red eye that clinically appeared consistent with an adenoviral keratoconjunctivitis. The signs and symptoms cleared within five to ten days in all three patients. When the patients reinserted their lenses after their initial episodes, the same signs and symptoms again developed, including follicular conjunctivitis, punctate keratitis, and subepithelial infiltrates. All three were using preserved solutions for soft lens disinfection, and when switched to thermal disinfection with saline tablets, a recurrence of the syndrome did not develop when the lenses were replaced. This syndrome seems related to a toxic or allergic reaction to the preservatives in the contact lens disinfecting solutions. Similar patients who have an acute or chronic, red, irritated eye should stop their lens wear and later should change their disinfection technique to one that uses unpreserved saline solution to eliminate the problem.

Adult↗
PubMed1981

The effect of a generic drug law on the retail cost of antiglaucoma medications.

The passage of the Missouri generic drug law in 1979 did not increase the dispensing of generic antiglaucoma medications, nor did it reduce retail prices. In 1976 and in 1980, antiglaucoma medications purchased with generic prescriptions were no less expensive than medications purchased with brand-name prescriptions. Almost all generic prescriptions were filled with brand-name products. A wide range of prices (approximately twofold) was noted from pharmacy to pharmacy for each drug. The retail cost of antiglaucoma medication increased approximately 35% between March and April 1976 and July and August 1980. This was less than the increase in the Consumer Price Index for the urban United States during the same period.

Costs and Cost Analysis↗