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Biomedical subjects

M Glick

Publications and source records attributed to M Glick.

At least 73 records · Page 4Linked to original sources
PubMed1991

Though disorder in high-functioning autistic adults.

Examined thought disorder in a sample (n = 11) of high-functioning autistic young adults and older adolescents (mean IQ = 83) utilizing objective ratings from the Thought, Language and Communication Disorder Scale (TLC Scale) and projective data from the Rorschach ink blots. Results from the TLC Scale pointed to negative features of thought disorder in this sample (e.g., Poverty of Speech). Rorschach protocols revealed poor reality testing and perceptual distortions in every autistic subject, and also identified several areas of cognitive slippage (e.g., Incongruous Combinations, Fabulized Combinations, Deviant Responses, Inappropriate Logic). Comparing TLC Scale and Rorschach results to schizophrenic reference groups, autistic subjects demonstrated significantly more Poverty of Speech and less Illogically on the TLC Scale, and on the Rorschach they evidenced features of thought disorder that are encountered also in schizophrenia. Results are discussed in relation to the measures employed, and to areas of similarity and difference between autism and schizophrenia.

Adolescent↗
PubMed1991

Intraoral cytomegalovirus lesion and HIV-associated periodontitis in a patient with acquired immunodeficiency syndrome.

Exposure to cytomegalovirus (CMV) is common in persons infected with the human immunodeficiency virus. Autopsy studies have documented the presence of CMV in multiple organs, but CMV is seldom indicated as the causative agent in specific diseases. Few reports have described localized CMV infection in the oral cavity. This may be due to the occult histopathologic appearance during oral mucosal CMV infections and to a lack of awareness of CMV infection as a potential etiologic agent in nonspecific oral ulcerations and other oral disease entities. This report describes an intraoral ulceration with documented presence of a localized CMV infection in association with human immunodeficiency virus-associated periodontitis in a patient with acquired immunodeficiency syndrome. A causative relationship between these two entities, however, cannot be established or excluded.

Acyclovir↗
PubMed1991

Human immunodeficiency virus infection of fibroblasts of dental pulp in seropositive patients.

Presence of human immunodeficiency virus (HIV) within noninflamed human dental pulps was documented by polymerase chain reaction assays in 11 of 12 pulps from HIV-seropositive patients. The purpose of the present study was to determine the cellular location of HIV in vivo within these tissues by means of in situ hybridization. Results of the in situ hybridization indicated HIV within fibroblasts of the pulp. These results are especially relevant because fibroblasts lack the CD4 receptor thought necessary for in vivo infection with HIV. These results suggest the fibroblast as a possible reservoir for HIV in the body.

CD4-Positive T-Lymphocytes↗
PubMed1991

Rapidly progressive periodontitis as an important clinical marker for HIV disease.

Acquired immunodeficiency syndrome (AIDS) patients are in desperate need of the clinical therapies that can enable them to retain their dentition for the rest of their lives. It is important to weigh the social, clinical-oral, and radiographic assessments with all patients, especially those with undiagnosed human immunodeficiency virus (HIV) infection. Many experience denial and are noncompliant with both medical and dental prevention. Many HIV-infection-related sequelae are first seen intraorally; dentists must be aware of them and consider all patients as HIV carriers until proved otherwise. HIV-associated gingivitis has been demonstrated to progress to HIV-associated periodontitis. Therefore, early recognition and management of HIV-associated gingivitis is essential to prevent the rapid loss of hard and soft periodontal tissues.

Acquired Immunodeficiency Syndrome↗
PubMed1991

Psychosocial aspects of treating the HIV-infected dental patient.

As the number of human immunodeficiency virus (HIV)-seropositive individuals and persons diagnosed with clinical acquired immune deficiency syndrome (AIDS) increases, dentists will find it increasingly difficult either to avoid caring for this group of patients or to justify referral. While clinical management alone has posed a new role for dentistry in the HIV epidemic, the psychosocial dimensions of patient care are presenting even more challenging difficulties for the profession. General dentists, especially, have heretofore not faced the need to address the special needs of patients known to have terminal infectious disease. Treating HIV-seropositive and AIDS patients will produce psychosocial difficulties normally not encountered by the dental team. There is a need to understand the psychosocial issues affecting the patient as well as the dental provider, in order to implement changes in our educational approach to future patient management.

Adult↗
PubMed1990

Sensitive, indirect photometric detector for high-performance liquid chromatography using a light-emitting diode.

A low-noise detector for indirect photometric detection has been constructed using a highly stable source--a light-emitting diode (LED). Use of the detector is demonstrated for reversed-phase liquid chromatography by adding methylene blue to the mobile phase to make a background signal. The indirect determination of alcohols by their effect on methylene blue concentration distribution is demonstrated, and an investigation is made into the conditions for high sensitivity. Because the source exhibits low noise, the detection limits for alcohols are as low as more complex and expensive detection methods, despite the lower radiant power of the LED. Detection limits for nine alcohols are below micrograms injected amounts.

Alcohols↗
PubMed1990

Laser-excited atomic fluorescence in a pulsed hollow-cathode glow discharge.

A pulsed glow discharge with low background noise is evaluated as an atom reservoir for laser-induced atomic fluorescence spectroscopy. Aqueous solutions are dried in graphite electrodes that are used as disposable hollow cathodes. Atomic vapor is produced in a flowing-gas glow discharge with a water-cooled cathode holder. A dye laser triggers a switching circuit that pulses that glow discharge, and fluorescence measurements are made 100 microseconds after the discharge is extinguished. The atomic population is large during this dark period, while the background emission is negligible. Linear calibration curves are obtained by nonresonance fluorescence for two elements, Pb and Ir. The detection limits for Pb are 100 pg/mL and 500 fg, and for Ir are 6 ng/mL and 20 pg. The experimental detection limit for Pb is compared to the intrinsic detection limit.

Lasers↗
PubMed1990

The clinical and histologic appearance of HIV-associated gingivitis.

Human immunodeficiency virus-associated gingivitis (HIV-G) has been described recently as a clinical entity in HIV-infected patients. However, little is known about the etiology and pathogenesis of this condition. We report a case of HIV-G in a 32-year-old man with acquired immunodeficiency syndrome (AIDS). The histology of the clinically involved gingiva revealed the absence of an inflammatory cell infiltrate. This report provides an initial description of the histologic changes occurring in HIV-G.

Acquired Immunodeficiency Syndrome↗
PubMed1990

Antibiotic prophylaxis in cesarean section.

Several controversies exist regarding the use of antibiotic prophylaxis in cesarean section. Studies have investigated effectiveness, choice of drug, timing, duration, and appropriate route of administration. Efficacy of antibiotic prophylaxis in preventing postoperative endometritis in certain high-risk patients has been well documented. Factors identifying patients at high risk for endometritis include: indigent socioeconomic status, labor prior to cesarean section, rupture of chorioamniotic membranes, and number of vaginal examinations. Although many different antibiotics have been tested, no particular regimen has been found to be superior. Administration of antibiotics after cord clamping reduces the risk of fetal exposure without compromising maternal risk of endometritis. A single dose of ampicillin or a first-generation cephalosporin (e.g., cefazolin or cephalothin sodium) given intravenously provides adequate prophylaxis. No additional benefit has been demonstrated with the use of multiple-dose regimens.

Anti-Bacterial Agents↗
PubMed1990

License to care.

Explore the source record for details and available documents.

Acquired Immunodeficiency Syndrome↗
PubMed1990

HIV-testing. More questions than answers.

Should all dental patients be screened for HIV antibody status, or should only specific individuals be tested? Will the result of a patient's HIV test change treatment procedures, or is there no advantage to testing patients? Many questions need to be answered prior to institutional HIV testing for dental patients.

AIDS Serodiagnosis↗
PubMed1989

Glucocorticosteroid replacement therapy: a literature review and suggested replacement therapy.

Administration of exogenous glucocorticosteroids will cause adrenal suppression lasting for up to 12 months; however, the patient's stress response will return within 14 to 30 days. This difference occurs as a result of the effects of corticotropin-releasing factor on the autonomic nervous system and on visceral systems. A new protocol for glucocorticosteroid replacement therapy is proposed that is based on the patient's ability to respond to dental stress.

Adrenal Glands↗
PubMed1989

Detection of HIV in the dental pulp of a patient with AIDS.

Dental pulp tissue from a patient with acquired immune deficiency syndrome (AIDS) was examined to determine the presence of the human immunodeficiency virus (HIV). The results found a high concentration of proviral HIV DNA.

Acquired Immunodeficiency Syndrome↗
PubMed1987

HLA-B51 may serve as an immunogenetic marker for a subgroup of patients with Behçet's syndrome.

Epidemiologic data, family history, clinical data, HLA typing, neutrophilic chemotaxis, and immunofluorescence of clinically normal non-sun-exposed skin were studied in 46 Israeli non-Ashkenazi Jewish and Arab patients with Behçet's syndrome. HLA-B51 was present in 71 percent of the patient group as compared with 13 percent of the control group (relative risk = 17.1). In four of 30 families in the B51-positive group, there was a close relative of the proband with Behçet's syndrome who was carrying the HLA-B51 antigen. Neutrophilic chemotaxis in this group was enhanced in 80 percent of the patients, and in most patients no deposition of immunoglobulin in the dermo-epidermal junction was observed, whereas C3 was present in papillary vessels. In the B51-negative group, the family history was negative for Behçet's syndrome, neutrophilic chemotaxis was enhanced in only two of eight patients, and in four of six patients, IgM deposition was detected in the dermo-epidermal junction. It is concluded that in Israeli non-Ashkenazi Jews and Arabs, there is a significant association between HLA-B51 and the risk of developing Behçet's syndrome. The B51-positive patient group has a family history of the disease, enhanced neutrophilic chemotaxis, and a lack of immunoglobulin deposition in the dermo-epidermal junction.

Behcet Syndrome↗