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Biomedical subjects

M Glick

Publications and source records attributed to M Glick.

At least 91 records · Page 5Linked to original sources
PubMed1987

Oral manifestations of disseminated Cryptococcus neoformans in a patient with acquired immunodeficiency syndrome.

A palatal lesion was the initial manifestation of disseminated cryptococcosis in a patient with acquired immunodeficiency syndrome (AIDS). The diagnosis was initially verified with cytologic smears in situ and later confirmed with pathologic findings from an excisional biopsy specimen. As cryptococcosis is one of the major opportunistic infections in persons with AIDS, an increased incidence of oral manifestations of cryptococcosis can be expected.

Acquired Immunodeficiency Syndrome↗
PubMed1986

Total population study of factors affecting chronic bronchitis prevalence in the coal mining industry of New South Wales, Australia.

The period prevalence of simple chronic bronchitis (SCB) (mucus hypersecretion), defined as chronic cough and sputum production by the MRC respiratory symptom questionnaire administered by occupational physicians and of obstructive chronic bronchitis (OCB) (airflow obstruction) (defined as SCB plus FEV1 less than 80% predicted) have been measured over the period 30 June 1977-30 June 1980 in the entire work force aged between 21 and 60 of the coal industry of New South Wales, Australia (12 357 men). Four dimensional contingency table analysis by a logistic transform method showed highly significant (p less than 0.001) additive affects of age (exposure duration), site of work, smoking, and alcohol consumption on development of overall chronic bronchitis (SCB + OCB). Odds ratios were face work:surface work = 1.78:1, smoker:non-smoker = 4.23:1, alcohol greater than 300 g/wk:alcohol less than 300 g/wk = 2.13:1. There was no evidence for synergistic effects of these factors on the development of mucus hypersecretion. When OCB was analysed separately, the effect of site of work, although in the same direction, was not statistically significant and this was assumed to be due to a "healthy worker" effect or a "swamping" effect of smoking. Age, smoking, and alcohol effects were highly significant (p less than 0.0001) and there was a sharp increase in prevalence of OCB in the age groups 41-50 and 51-60. Odds ratios were face work:surface work = 1.11:1, smoker:non-smoker = 2.66:1, alcohol greater than 300 g/wk:alcohol less than 300 g/wk = 2.91:1. There was no evidence of synergistic effects. These results are consistent with a hypothesis of additive effects of smoking, alcohol, and coal mine dust and fumes on the development of chronic mucus hypersecretion leading to airflow obstruction or a hypothesis of similar additive effects on the development of two separate conditions--mucus hypersecretion with airflow obstruction and mucus hypersecretion without airflow obstruction.

Adult↗
PubMed1986

Measurement of total bilirubin by use of bilirubin oxidase.

We used an enzymatic method for measuring total bilirubin in serum. Results by this method varied linearly with bilirubin concentrations to at least 300 mg/L. The day-to-day precision (CV) of the method ranged from less than 1% to about 11% at bilirubin concentrations of 183 and 12 mg/L, respectively. Commonly used anticoagulants, serum preparation materials, and selected drugs had no effect on the apparent bilirubin concentration, but turbidity caused a slight increase and hemoglobin concentrations of 2 g/L resulted in lower values, by as much as 17 mg/L at a bilirubin concentration of 95 mg/L. Patients' results obtained with this enzymatic method were slightly lower than those obtained with methods based on the Jendrassik-Grof principle. The largest differences, seen in samples with high "direct" bilirubin concentrations, can be decreased by measuring the absorbance at 425 nm instead of at 465 nm as recommended by the supplier of the bilirubin oxidase method.

Adult↗
PubMed1985

Developmental correlates of age at first hospitalization in nonschizophrenic psychiatric patients.

Age at first hospitalization, premorbid social competence, and developmental categorizations of symptomatology were examined in 228 male and 220 female patients in three diagnostic categories: major affective disorder, neuroses, and personality disorder. High social competence patients were older at first hospitalization than low competence individuals. Younger first admission patients showed more symptoms in the action category and in the role orientation of turning against others. Older patients more frequently displayed symptoms of the thought variety and of turning against the self. Gender differences in age at first hospitalization were not found. With respect to all developmental variables examined, the results suggest that a broader view of prognosis proposed in research with schizophrenic patients is applicable to nonschizophrenic groups.

Adult↗
PubMed1984

The conus demyelination syndrome in multiple sclerosis.

Bowel, bladder and sexual dysfunction are common in multiple sclerosis and are generally attributed to the widespread nature of the involvement of the neuroaxis by the demyelinating plaques. Recently we encountered a specific subset of patients within this group who had characteristic clinical complaints of hesitancy, straining and incomplete voiding, perineal hypesthesia on examination, areflexia by cystometry and colonometry and electrophysiological parameters suggesting involvement of the conus medullaris. This heretofore postulated but undocumented mechanism of neurovisceral dysfunction in multiple sclerosis is detailed and discussed in 2 patients in this report.

Adult↗
PubMed1982

Colonometry, cystometry, and evoked potentials in multiple sclerosis.

The conditions of three patients with advanced-stage multiple sclerosis and symptoms related to bowel and bladder function were evaluated using colonometry, cystometry, and somatosensory evoked responses from the posterior tibial nerve. The colonometrograms and cystometrograms showed notable hyperreflexia and reduced filling capacity when compared with neurologically intact patients. The neurological lesions were localized to above the conus medullaris by recording normal somatosensory responses at L-1 and abnormal responses over the scalp. This combination of tests are important in the documentation of bowel and bladder dysfunction, the localization of the neurological lesion causing the symptoms, and the determination of treatment of bowel and bladder symptoms in patients with multiple sclerosis.

Brain↗
PubMed1981

Premorbid social competence and the revolving door phenomenon in psychiatric hospitalization.

The relation between premorbid social competence and length of initial hospitalization was examined in 381 male state hospital patients in four diagnostic categories: schizophrenic, affective reaction, psychoneurotic, and personality disorder. A significant relation was discovered between diagnosis and outcome, with schizophrenic patients having the longest and personality disorder patients the shortest lengths of initial hospitalization. Premorbid social competence was related to outcome, as assessed both by length of initial hospitalization, and by whether the patient was rehospitalized. These two outcome measures were found to be positively related, thus supporting the developmental formulation that premorbid social competence is indicative generally of prognosis. The findings were employed to generate the inference that patients at differing levels of premorbid social competence require different treatment modalities.

Adult↗
PubMed1980

Inter-relationships among hospitalization measures of psychiatric outcome.

In a diagnostically heterogeneous sample of 381 first admission male state hospital patients, no consistent correlations appeared among three commonly employed hospitalization measures of outcome. The possibility that psychiatric hospitalization may be a multidimensional criterion is considered and the implications for outcome research are discussed.

Follow-Up Studies↗
PubMed1979

Premorbid social competence and outcome among schizophrenic and nonschizophrenic patients.

The relation between premorbid social competence and outcome was examined with 381 male state hospital patients in four diagnostic categories: schizophrenia, affective reaction, psychoneurotic disorder, and personality disorder. Outcome was assessed using the measures of length of initial hospitalization, total length of rehospitalization, and number of readmissions. The follow-up period was 3 years after discharge from the first hospitalization. On all outcome measures, higher social competence was significantly related to favorable outcome. The four diagnostic groups differed significantly in social competence level, but no evidence was found to indicate that the social competence-outcome relation was influenced by diagnosis. Results were interpreted as consistent with a developmental formulation and as indicating that the relation between premorbid social competence and outcome is not unique to schizophrenia but obtains over a broad range of diagnoses.

Affective Symptoms↗