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Biomedical subjects

M Ghosh

Publications and source records attributed to M Ghosh.

At least 163 records · Page 9Linked to original sources
PubMed1981

Distribution of silver in the eyes and plasma proteins of the albino rat.

Albino rats were given a 0.25% solution of silver nitrate to drink for 10 weeks, then were divided into two groups. One group continued to drink the solution for an additional 6 months, while the other group was given water to drink for an additional 12 months. The ingestion of silver nitrate retarded the growth of the rats and eventually caused their death. The rats regained weight and appeared to grow normally when the silver nitrate regimen was withdrawn. Radioactive silver in the plasma was found to be almost exclusively in a single electrophoretic protein band. Examination of the rats' eyes by electron microscopy showed deposits of silver particles in Bruch's membrane, the basement membranes of the choriocapillaris and the ciliary processes, and the stroma of the choroid and ciliary processes. The number and size of the particles increased with continued ingestion of silver but decreased if the silver regimen was withdrawn after the initial 10 weeks of ingestion. Fine particles of silver were still present 12 months after the end of the ingestion of silver nitrate. At no time were silver particles seen in the basement membranes or endothelial cells of the retinal capillaries or within the cytoplasm of the pigment epithelium or the epithelial cells of eh ciliary processes.

Animals↗
PubMed1980

Pathological findings from two cases of choroideremia.

Light and electron microscopic study of material from two cases of old, quiescent choroideremia led to three conclusions: there was nearly total loss of the outer segments of the visual receptors, there was reduplication of the basement membrane of the pigment epithelium and thickening of Bruch's membrane, and there was gliosis of the inner part of the retina and a preretinal membrane.

Adolescent↗
PubMed1979

Epithelial downgrowth following cataract extraction.

This case of epithelial downgrowth following cataract extraction shows the typical sequence of a noneventful cataract extraction with satisfactory recovery but after a time, the appearance of conjunctival injection, iritis and attacks of elevated ocular pressure. A minimal membrane on the posterior surface of the cornea could be seen but the diagnosis rested on the sequence of events and was confirmed by the pathologic investigation. The apithelial cells grow freely on the iris, but extend onto the cornea and posteriorly apparently without hindrance. The epithelial cells form a basement membrane next to the iris, much as they do on the surface of the cornea next to Bowman's membrane. The source of the cells in this case was not identified; they presumably came from conjunctiva although no track through the sclera was found and the cells themselves did not show goblet cells.

Aged↗
PubMed1978

Whorl-like degeneration of corneal epithelium a clinico-pathologic study.

A case of epithelial corneal degeneration that was first seen as a pigmented plaque but changed to a whrol-like pattern and then partially regressed is described. The pathologic abnormality was an intra-cellular inclusion of lipid in the basal cells and of lipid and mucopolysaccharide in the wing and superficial cells. No duplication of basement membrane or thickening of Bowman's layer was present. It is suggested that despite different origins the pathologic entity in this case, in Fabry's disease and in chloroquine keratopathy is similar. The whorled pattern is due to a sliding of the corneal epithelial cells as they rise from the basal cells to the surface, much as a cyclonic flow forms about an atmospheric low in the southern hemisphere.

Aged↗
PubMed1978

Zinc and copper content in rat epididymis and vas deferens.

The zinc and copper content in the different epididymal segments and vas deferens of castrated rats were investigated with the help of atomic absorption spectrophotometer. The vas deferens showed maximum zinc content as compared to that of different parts of epididymis in all groups whether castrated unilaterally, bilaterally or in the intact control. Zinc content was reduced in the epididymis and vas deferens ipsilateral to the castrated side as compared to that of contralateral control and intake animals. Lowest zinc content was observed in the epididymis and vas deferens of bilaterally castrated animals from that of other groups. Absence of sperms was observed in all segments of epididymis and vas in bilaterally castrated animals and from the unilaterally castrated side. Copper content was unaltered in all epididymal segments and vas deferens. There appears to be a correlation between the absence of sperms in the male genital tract and the decrease in zinc content.

Animals↗
PubMed1977

Crystalline dystrophy of the cornea: a light and electron microscopic study.

We examined biopsy material from a case of stromal crystalline dystrophy of the cornea by light and electron microscopy. Frozen sections were positive for neutral fat and negative for cholesterol. Electron microscopy showed that the empty spaces at the site of the crystals did not have typical crystalline profiles. We concluded that in our case the crystals were composed of neutral fat.

Adult↗