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Biomedical subjects

M Ghosh

Publications and source records attributed to M Ghosh.

At least 181 records · Page 10Linked to original sources
PubMed1976

The conjunctiva in senile lens exfoliation.

Conjunctival biopsy specimens from both eyes of a series of seven patients with evidence of unilateral senile exfoliation of the lens were examined by electron microscopy. Exfoliation fibers were found in both eyes of each patient. This evidence suggests that the conjunctiva is an independent source of exfoliation that precedes the development of exfoliation in the lens.

Aged↗
PubMed1976

Conjunctival eye signs in GM1 type 1 gangliosidosis.

Two cases of GM1 type 1 gangliosidosis demonstrated microvascular abnormalities of the conjunctiva, as well as skin abnormalities in one case. This abnormality was studied by light and electron microscopy of a conjunctival biopsy; cytoplasmic vesicles were noted in the endothelial cells, producing a mechanical narrowing of the lumen. This storage material is similar to that seen in the fibroblasts of skin and of visceral organs in GM1 gangliosidosis, as well as to the material described in the systemic mucopolysaccharidoses. The material probably represents a keratan sulfate-like material. The conjunctiva provides a ready source for biopsy and diagnostic evaluation.

Conjunctiva↗
PubMed1975

Labrador keratopathy: clinical and pathological findings.

The clinical and pathological features of Labrador keratopathy are described. Some indication is given of the frequency of the condition in Northern Newfoundland and Labrador. The histopathology, based on light and electron microscopy of five specimens, is illustrated. The findings support an origin for the globular deposits in the stroma and Bowman's layer rather than the epithelium.

Age Factors↗
PubMed1975

Anterior subcapsular cataract. An electron microscopic study.

Electron microscopic findings from a case of anterior subcapsular cataract are presented. It is suggested that the epithelial cells increase in activity, form fibrillae and multiple layers of basement membrane, and these make up the anterior plaque. The same activity, to a lesser degree, is present under the posterior capsule. This abnormal function of forming fibrillae and basement membrane along with increased ribosomal activity may be called pseudometaplasia.

Basement Membrane↗
PubMed1975

Lecithin cholesterol acyl transferase deficiency. Light and electron microscopic finding from two corneas.

Two brothers with LCAT deficiency are reported. Corneal specimens were studied from both patients by electron and light microscopy. The electron microscopy revealed numerous vacuoles in both Bowman's layer and anterior stroma with some having electron dense material within the vacuoles. Conventional strains including frozen sections for lipid with light microscopy failed to reveal these vacuoles or any pathology. The composition of the contents of the vacuoles remains unsolved.

Acyltransferases↗