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Biomedical subjects

M Franz

Publications and source records attributed to M Franz.

At least 145 records · Page 8Linked to original sources
PubMed1988

The fine structure of male and female Onchocerca gibsoni.

The fine structures of the midbody regions of male and female Onchocerca gibsoni are described. The epicuticle is wrinkled in the male, and forms long protuberances in the female worm. The lateral chords of the female specimens contain many bacteria and dense bodies. In both sexes the intestinal cells are filled with concentric spherules and the intestinal lumen is extremely reduced. The fine structures of O. gibsoni are very similar to those of O. volvulus.

Animals↗
PubMed1987

Electron-microscopic observations on the female worms of six Onchocerca species from cattle and red deer.

The midbody regions of female worms of six Onchocerca species (O. flexuosa, O. tarsicola, O. lienalis, O. gutturosa, O. armillata, O. gibsoni) were studied by transmission electron microscopy. The cuticular layering was rather similar in all species with the ridges built up by the cortical layers and the inner cuticular striations by the median or basal layers. Differences in the epicuticular morphology were considerable. O. flexuosa and O. lienalis had a thin epicuticle without protuberances, the epicuticle of O. armillata carried small knobs, and O. tarsicola, O. gutturosa, and O. gibsoni had a thick trilaminar epicuticle with long protuberances. Extreme hypertrophy of hypodermis and reductions of somatic musculature were observed in O. flexuosa and O. gibsoni. Less extended thickenings of the hypodermis were observed in the other species. No degenerative alterations were found in the muscle cells of O. gutturosa and O. lienalis. The intestinal lumen of most of the species was in a central position, but in O. tarsicola and O. gibsoni the lumen was reduced to small clefts between the intestinal cells. In these species, numerous electron-dense, concentric granules were observed in the cytoplasm of the intestinal cells. The proportions of the various organs differed considerably from species to species, e.g., the uteri contained the embryos filed one behind the other in O. tarsicola, whereas 50 or more embryos were found beside one another in cross-sections of the uterus of O. gibsoni. The comparative study showed that O. gibsoni and O. volvulus have many derived morphological characteristics in common and that in the other species more primitive stages of development of these morphological marks can be observed.

Animals↗
PubMed1987

Morphological alterations in female litomosoides carinii after treatment with two benzthiazole derivatives in vivo.

Multimammate rats (Mastomys natalensis) infected with Litomosoides carinii were treated 65 days after infection with a single oral dose of 50 mg/kg of CGP 20308 or CGP 20376 (Ciba Geigy Limited, Basel). Autopsies were performed between 1 and 28 days after treatment. The numbers of worms and the numbers and condition of intrauterine developmental stages in the females were determined. Other female filariae were investigated by transmission electron microscopy (TEM). Female filariae were observed to be immobile on Day 2, later became encapsulated, and had almost disappeared on Day 28. The number of embryos had decreased on Day 6 and even more on Day 14, when only 5-10% appeared light-microscopically unaffected. TEM examination of the filarial midbody regions revealed, that the fine structures of all somatic muscle cells began to disintegrate as early as Day 4 after treatment with either drug. The breakdown of these cells was increased on Day 6 and Day 14. The cytoplasm of the nerve fibres was more electron-dense in treated than in untreated worms. No alterations were observed in the hypodermis, the cuticle, the intestine and the uterine epithelia. Sections from anterior and posterior regions of the parasites were studied after treatment with CGP 20308 only. Degenerating nerve fibres were found in the nerve rings of these filariae 4 days after treatment.

Animals↗
PubMed1986

Fine structure of adult Litomosoides carinii (Nematoda: Filarioidea).

The fine structure of the body wall and the intestine of male and female Litomosoides carinii was studied in sections through the middle and posterior regions of the worms. In the sublateral cells of the female hypodermis the organelles are arranged in regular layers. The zone with the basal labyrinth is the most prominent layer. The intestinal epithelium of the female worm varies considerably in thickness. The cytoplasm of these cells contains many large droplets. The lateral hypodermal chords of the male worm are very narrow bands. The muscle cells of the male worm are of the circomyarian type, without an afibrillar portion. The intestinal lumen of the male worm is very narrow, and the epithelial cells contain very large droplets. In both sexes the hypodermis contains bacteria. Larger glycogen deposits were absent in the hypodermal chords and in the muscle cells of the midbody regions.

Animals↗
PubMed1986

Histology of adult Litomosoides carinii (Nematoda: Filarioidea).

The histology of male and female Litomosoides carinii was studied in serial sections. The body wall of the female worm consists of a rather thin cuticle, very extended lateral hypodermal chords and small sectors of shallow coelomyarian muscle cells. In the female worm an intestinal lumen is found, which is filled with material throughout the worm's length. Both ovaries are situated close to the posterior end. In both genital tubes all stages of oogenesis and embryogenesis could be observed in approximately equal stages of development in most of the sections. The lateral chords of the male worm are very small, whereas the somatic muscle cells are large and of the circomyarian type. The intestine is a minute tube beside the much thicker testis and vas deferens. Considerable sexual dimorphism could be observed in almost all organs of adult Litomosoides carinii.

Animals↗
PubMed1986

Histology of adult Brugia malayi.

Two male and two female Brugia malayi were collected from Mastomys natalensis, and cross sections from various regions of these worms were studied. The body wall of the female worm is thin throughout its length, whereas in the midbody and posterior region of the male worm the somatic muscles form a thick layer. In both sexes the intestine is thickest immediately behind the oesophagus and tapers posteriorly. The lumen was empty in all sections. In both genital tubes of the female worm a successive row of developmental stages could be observed. The rather short ovaries lie in the posterior region. The fertilisation chambers and the following regions are the thickest portions of the uteri. The testis is situated in the anterior region of the male worm, whereas in the midbody and posterior regions the vas deferens contains stretched spermatozoa. Compared to other filariae the sexual dimorphism is not very pronounced in this species.

Animals↗
PubMed1985

Nutrition update.

Explore the source record for details and available documents.

Dietary Fats↗
PubMed1984

Electron microscope study of the body wall and the gut of adult Loa loa.

The morphology of the body wall and the gut in the midbody region of adult male and female Loa loa originating from patients in Gabon was studied by transmission and scanning electron microscopy. The cuticle of the dorsal and ventral regions consists of ten layers. In the lateral regions the cuticle is thicker and includes two additional layers. The thin hypodermis contains numerous transhypodermal fibres. A row of median cells is situated between the syncytia in each lateral chord. No intracellular bacteria were observed. The cross-sections of each of the four muscle sectors are comprised of approximately 12 muscle cells of the coelomyarian type. The plasm of the gut cells contains large vacuoles and several mitochondria. The intestinal wall surrounds a wide lumen filled with material which occasionally contains cellular structures. The morphology of L. loa is compared with that of adult Onchocerca volvulus and Brugia malayi. The gut of the adult L. loa has the typical nematode morphology, which might be an indication of its normal function in nutrition. The multilayered cuticle with the rather smooth surface, and the prominent muscles correspond to the migratory activity of this filaria.

Animals↗
PubMed1983

Mitral valve replacement with preservation of papillary muscles and chordae tendineae - revival of a seemingly forgotten concept. I. Preliminary clinical report.

In 45 consecutive patients mitral valve replacement was performed leaving the posterior mitral leaflet and its chordal attachment to both papillary muscles intact (Lillehei's technique). Most patients showed moderate to severe pulmonary hypertension before surgery, 15 of the patients had double valve operations and 4 had a triple valve procedure. All patients survived and were discharged, the postoperative courses being remarkably uneventful with only very limited need of inotropic support in 3 patients and resumption of spontaneous respiration within the first 20 hours after the operation. The clinical courses in these patients seem to indicate that preserving the continuity between papillary muscles and mitral annulus in mitral valve replacement may improve left ventricular function at least early after surgery.

Adult↗
PubMed1983

The fine structure of adult Onchocerca volvulus IV. The hypodermal chords of the female worm.

The morphology of the hypodermal chords in the anterior, midbody and posterior region and in worms of different ages are described and the amphids, the cephalic papillae and the nerve ring are demonstrated. At the anterior end, the hypodermal cap comprises the sensory organs. Close behind, the hypodermal chords are differentiated, and several cell margins are found in all of them. Four sublateral chords are differentiated, and several cell margins are found in all of them. Four sublateral chords are also found in the anterior region. A row of median cells is found between the dorsal and ventral syncytia further behind and at the posterior end. In the midbody region, the lateral chords are very large but without central cells. Various particles and inclusions such as bacteria, dense bodies and fibrils are found in the plasm of the hypodermal chords. A large multilayered inclusion was found in the degenerating chord of a female worm at least five years old.

Animals↗
PubMed1983

The fine structure of adult Onchocerca volvulus. V. The digestive tract and the reproductive system of the female worm.

The morphology of the oesophagus, the intestine, the ovary, the uterus, the vagina and some inclusions in the body cavity are described in worms of different ages. The oesophagus wall comprises mostly muscle fibrils and a few glandular regions located only in the posterior portion. In the lumen, some material was found. From the anterior to the posterior end, the lumen of the intestine is reduced. The plasm of the intestinal cells of older worms is filled with concentric spherules containing iron, which are absent in mature but not full-grown worms. The ovarial cells contain in their outer region some fibrils and in the inner region some dense bodies. The ring-muscles of the uterine wall run in clefts of the basal lamina. They usually have accumulated iron containing bodies. In the final portion of the uterus and in the vagina the muscles are very thick. A comparison of the general morphology of the midbody regions of young, not full-grown worms, one less than five years old worm and some worms at least five years old is given.

Aging↗
PubMed1983

The fine structure of adult Onchocerca volvulus. III. The cuticle, the interchordal hypodermis and the muscle cells of the female worm.

The morphology of the cuticle, the interchordal hypodermis and the muscle cells of three mature but not full-grown worms, one worm less than five years old, two worms at least five years old and seven worms of unknown age are described. The cuticle in the anterior region is very similar to that of the male worm, however, in the midbody region the cuticular structure is more simple. The length of the folds of the surface membrane and the thickness of the coat vary considerably. The outer surface of the hypodermis is increased by lamellae, the inner surface by a labyrinthine system of folds. The structure of the muscle cells is simpler than in the male worm: degenerative alterations are found frequently comprising reduction of the afibrillar portion, separation of the filaments from the septa, disintegration of the filaments, and separation of the plasma from the laminae and finally total disintegration of the cell, leaving the empty laminal coverings behind.

Animals↗