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Biomedical subjects

M Forest

Publications and source records attributed to M Forest.

At least 91 records · Page 5Linked to original sources
PubMed1982

[An experimental study of bioglass implants in bone (author's transl)].

The tolerance and response of bone to bioglass have been studied using implants of various chemical constitution in animals. Glass discs were inserted between the inner and outer tables of the skull in 32 rabbits and small glass stick were implanted in the medullary cavity of long bones in 6 dogs. The results were analysed between 6 and 18 months later. High resolution radiographs and histopathological examination were performed. Some glass behaves like an inert material but other specimens are biodegradable and induce a satisfactory bone response in adjacent bone. Any new bone formation does not follow the classical stages of connective tissue, cartilage and woven bone. Bioglass is more suitable for bone than many other materials now in use and further applications in orthopaedic surgery may be considered.

Animals↗
PubMed1981

[Klinefelter's syndrome associated with precocious puberty due to tumoral secretion of chorionic gonadotropins].

A 8 and a half year-old boy presented with precocious puberty related to a malignant thoracic teratoma. He was also shown to have a Klinefelter syndrome. Precocious puberty related mainly to the liver, intracranial or thoracic tumors is rare. It seems to be exclusively observed in boys. The slight testicular enlargement is the main clinical sign. The contrast between high LH and low FSH levels is the most striking biological data. The diagnosis is proved by plasma HCG, beta-HCG and alpha-foetoprotein determination. Our patient is the third one with Klinefelter syndrome; this this association is certainly not fortuitous.

Child↗
PubMed1981

[Morphological study of a bone tumor. I. Macroscopic, radiographic and cytological aspects (author's transl)].

Pitfalls in histological studies of bone tumor are mostly due to inadequate macroscopic procedures and lack of precise radiological data. Simple technical steps are suggested, including methods of studying resection or amputation specimens, radiographs of tumoral sections, and procedures for obtaining good quality cytological images, particularly useful for the analysis of some types of bone tumors.

Bone Neoplasms↗
PubMed1980

[XY pure gonadal dysgenesis. Two cases report (author's transl)].

Two cases of XY dysgenesis are reported. In one case, that of a 13 year-old girl presenting with impuberism, a gonadoblastoma was detected by histologic examination of the streak. In the second case, that of a 6 month-old girl, short stature and dysplasia of the nails suggested the diagnosis.

Adolescent↗
PubMed1979

Clear-cell chondrosarcoma: a report of five cases including ultrastructural study.

Five cases of clear-cell variant of chondrosarcoma (Unni et al.) are reported. The tumors occurred in the epiphyseal region of long bones; three in the femoral head. Roentgenographically, the lesion was usually a well-defined and benign appearing one, either purely lytic (3 cases) or with central radiodensity (2 cases). Histologically, all five cases had areas of conventional chondrosarcoma; however, the greater portion of the tumor was made up of sheets of clear-cells intermixed with nonneoplastic bone trabeculae but devoid of chondroid matrix. Electron microscopic studies showed that these clear-cells possess cytoplasmic microvilli, abundant glycogen particles and prominent golgi complexes, like normal or tumorous chondroid cells usually have. In our experience, the best treatment seemed to be en bloc resection with joint replacement; indeed, despite the fact that they are true chondrosarcomas, these tumors usually have a very slow rate of growth.

Adolescent↗
PubMed1979

[Osteogenic aneurysmal orbital cysts].

The orbital form of this osseous tumor-like dystrophy is quite rare. The illustrated description of a new case is reported and the 13 cases of the literature reviewed. The main clinical and radiological data as well as the different treatments are commented upon. The anatomo-pathologic discussion focuses on the morphological aspects, hypotheses on the pathogenesis and differential microscopic features of the lesion as compared to other osseous lesions of the orbital bones.

Bone Cysts↗
PubMed1979

[Aneurysmal cyst of the orbit (author's transl)].

A child of 11 years of age was found to have an aneurysmal cyst of the orbit. This is an extremely rare cause for tumoral exophthalmia in children and the localization in this region is also very unusual. Only 14 cases are reported in the published literature. The main differences in relation to those occurring in the long bones and vertebrae are the constant absence of pain and the almost exclusively osteolytic radiological appearance.

Adolescent↗
PubMed1979

[Massive orbital osteolysis by a chordoma. Report of a case and review of the litterature (author's transl)].

Clinical, radiological and anatomical description of sellar chordoma giving, on a sixty seven years old man, an unusually large tumoral exophthalmos, a massive orbito-sphenoidal osteolysis and a chiasmatic syndroma. Discussion stresses the topographic data of chordoma in connection with the embryonal chordal cell rests. Patterns of evolution and neuro-ophthalmologic symptoms of cephalic chordoma are studied with the literature facts. Morphologic criteria, specifical ones and those differential diagnosis, are exactly scheduled.

Aged↗
PubMed1978

[Clear-celled chondrosarcoma or chondroblastic sarcoma. A new type of chondrosarcoma (author's transl)].

The authors report five cases treated by wide resection. Pathological studies were made of the whole of the lesion. Three tumours were situated at the upper end of the femur, one at the upper end of the humerus and one at the level of the tibial plateau. The specific features were localisation in an epiphysis and histological areas of clear cells whose cytoplasm contained glycogen. From the anatomical and radiological points of view, these tumours were like chondroblastomata but their progress was more like that of chondrosarcomata. The author concludes that they should be distinguished from both types of tumour.

Adult↗
PubMed1978

[Partially hormone dependent bilateral malignant polyadenomatous hyperplasia].

Bilateral malignant polyadenomas of adrenals seem to be rare. They involve either a double primary adrenal tumour, or a metastasis of a controlateral tumour. In the observation reported here, the evolution is characterized by periods of central stimulation with partial autonomy, and periods of tumoral autonomy with central inertness. Pathological findings consist of coexistence of various histological aspects (atrophy, hyperplasia, benign adenoma, carcinoma) suggesting the successive steps of a very particuliar adrenal carcinogenesis. Such findings allow to discuss the following physiopathological mechanism: a stimulation by ACTH might have resulted initially in a preneoplasic hyperplasia, then in an incompletely autonomous tumour, and finally in an autonomous tumour. Accordingly, from a practical and therapeutic point of view, it would be suitable, after removal of an adrenal tumour, especially of one with demonstrated ACTH-dependance, to suppress totally endogenous ACTH by cortisol or cortisone therapy, in order to reduce the occurence of corticotropin stimulation of possibly remaining malignant adrenal cells.

Adenoma↗