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Biomedical subjects

M Forest

Publications and source records attributed to M Forest.

At least 109 records · Page 6Linked to original sources
PubMed1977

[Intranuclear inclusions in giant cell bone tumor. Demonstration by electron microscopy].

In a case of giant cell tumour of bone, electron microscopy revealed filamentous inclusions within the nuclei of all the giant cells. Although not invariably present in such tumours, their similarity with the nucleocytoplasmic inclusions seen in osteoclasts in Paget's disease is underlined. This raises interesting questions as to their nature and the histogenesis of these disorders.

Adult↗
PubMed1976

[Metastatic fractures of the femur. Apropos of 100 cases].

The authors have treated one hundred fractures of the femur of metastatic origin. They conclude that surgery, when technically possible, should always be undertaken. Internal fixation gave better results than prosthetic replacement of the upper end of the femur. Intramedullary nailing can be followed by radiotherapy and shaft fractures may unite after such treatment. The treatment of the primary lesion must be started as soon as possible by radiotherapy or chemotherapy.

Arthroplasty↗
PubMed1975

[Bone metastases of colonic and rectal neoplasms. Apropos of 11 cases].

The authors report 11 personal cases and discuss the characteristics of bony metastases in carcinoma of the colon and rectum. The frequency of these metastases is fairly low (1.3% of all cases of bony metastases) as tumours of the large intestine do not tend to migrate to the bones. Sometimes bony metastases are the presenting symptom but, usually the metastases occur within 5 years of the diagnosis of the primary tumour. The clinical picture shows no special characteristics. Radiologically, these bony metastases may be either single or multiple. Their distribution recalls that of other metastases in the bones with a few differences, however. The special frequence of pelvic involvement, distal localisations (hands or feet) are not exceptional. Metastases usually give rise to osteolysis. The mixed appearances are, however, not rare, and usually give a pseudo-sarcomatous appearance, with invasion of the soft parts and very marked periosteal reaction. Sometimes, bony condensation may be noted. The treatment of rectal and colonic cancer with bony metastases, is disappointing as the disease is always fatal within a relatively short period, usually less than one year after the diagnosis of the bone involvement. The histological appearances of the bony lesions depend on differenciation of the tumour and the characteristics of the neighbouring bony abnormalities which, in our experience, usually include both osteolysis and osteogenesis.

Age Factors↗
PubMed1975

[The coxopathies of Paget's disease. Radio-clinical and anatomopathological study].

A systematic study was carried out on 105 patients with Paget's disease (60 men and 45 women, average age 62 years) involving the acetabulum and/or the femoral head in the juxta-articular zone. In two-thirds of the patients only the pelvis (in particular the acetabulum) was affected, in a quarter both the pelvis and the femoral head were affected, and in one case in ten only the femoral head. 1. 18 coincidental coxopathies should first be excluded (12 coxarthrosis, 2 coxitis, etx.). The occurrence of 17 percent of coxopathies not caused by Paget's disease is normal in older patients (Vignon and Jacquet; Sebban, Lequesne et al.). 2. In 105 cases, there were only 50 coxopathies really due to Paget's disease, of which almost half remained painless. 3. This proportion did not vary with age. On the other hand, coxopathy was more frequent in patients with bipolar, pelvifemoral Paget's disease and above all in Paget's disease with acetabular protrusio. 4. The radiographic appearance is slightly different from that of coxarthrosis; the reduction in joint space is more often internal or supero-internal (50 percent of cases); osteophytosis is usually moderate (22 percent of cases), or absent (48 percent). The geodes are rarely visible : 6 percent of cases. 5. The acquired bone deformations in patients with Paget's disease are classical. In 105 cases, the authors noted 14 acetabular protrusions, all with coxopathies, and 10 coxa vara, 5 of which had coxapathies. Anatomo-pathological studies did not reveal anything in particular about the bone : superimposition of the Paget's disease lesions and of the lesions usually found in cases of coxopathy due to overload, with a dense pressure cone. With reference to cartilage, the lesions of Paget's coxopathies presented several specific characteristics compared with those of common arthrosis : (1) the presence of particularly numerous cupshaped defects on the remaining cartilage; (2) a very basophilic, intra- and extra-cytoplasmic substance impregnated the chondroplasts of the bottom layer, nine times out of twenty-six, an anomaly not observed in cases of arthrosis; (3) pseudo-angiomatous vascular outgrowths from the bone, flush with the articular surface of the acetabulum are a source of bleeding during surgery.

Adult↗
PubMed1975

[Benign chondroblastomas of bone. Anatomo-clinical and ultrastructural study apropos of 11 cases].

The authors have observed 9 cases of benign chondroblastoma of bones. After a review of the literature they recall that this is a rare condition (1% of bone tumors). That it is twice more frequent in males than in females. Aged 10-20, at the level of growing epiphysis shoulder and knee are the more common sites. The X-rays pictures are described, as well as the pathological findings. Pathological features close to those noted in aneurismal bone cysts were often encountered. The ultra-structure of these tumours was also studied. This type of tumour is essentially benign, however the association of aneurism-like pictures increase the incidence of recurrences.

Adolescent↗
PubMed1970

[Megacalycosis].

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Adult↗