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Biomedical subjects

M Doi

Publications and source records attributed to M Doi.

At least 379 records · Page 21Linked to original sources
PubMed1980

Side-effects of prosthetic materials on the human body.

The authors report 6 patients (7 joints) in whom inflammation, dermal necrosis, dermatitis or fistula formation was attributed to the materials commonly used for joint endoprostheses. Histological appearances and chemical analyses of the involved tissues are presented, together with a discussion of the possible mechanism and methods of diagnosis and treatment.

Adult↗
PubMed1979

Argyrophil cell carcinoma of the uterine cervix with ectopic production of ACTH, beta-MSH, serotonin, histamine, and amylase.

The case of a 38-year-old female with primary argyrophil cell carcinoma of the uterine cervix is reported. Two years after operation the patient developed widespread metastases with typical Cushing's syndrome. Microscopically, the tumor consisted of solid anaplastic cells, adenocarcinoma, and squamous cells. The plasma levels of ACTH and cortisol were elevated. Many cells of both the primary and metastatic tumors showed argyrophilia. Almost all the cells of the metastases contained numerous round secretory granules measuring about 117 micrometers in diameter. Small rod-shaped or larger round secretory granules, measuring 250 and 430 micrometers respectively, were also found in a few of these cells. The tumors in the right lung, pancreas, and kidney contained high levels of ACTH, beta-MSH, serotonin, histamine, and amylase. This is the first report of ectopic production of these five substances from argyrophil cell carcinoma of the uterine cervix.

Adrenocorticotropic Hormone↗
PubMed1979

Carbamazepine as a sole anticonvulsant for partial seizures.

The efficacy, serum concentration and side effects of CBZ for partial seizures in children were evaluated. The study was undertaken on 27 patients with partial seizures ranging from 5 to 17 years of age. Further 15 patients with various types of epilepsy taking CBZ with other anticonvulsants were selected as controls to compare the serum levels of CBZ. In nineteen of the 27 patients seizures were controlled completely, in whom serum CBZ levels varied fro trace to 15.6 mcg/ml, average being 8.18 +/- 3.40 mcg/ml, while those of uncontrolled ones ranged from 3.5 to 11.3 mcg/ml, average being 7.50 +/- 2.97 mcg/ml. There was no significant difference between both groups of the above. EEG was improved in the seven of 19 seizure-free cases, serum levels of which ranged from 5.9 to 13.2 mcg/ml. With regard to the side effects, transient leucopenia was observed in four patients and serum GOT and GPT slightly elevated in two. Correlation between dose and serum level in the monotherapy group was not significant as well as in the combined therapy group. Serum DBZ levels in the monotherapy group were significantly higher than those in combined therapy group.

Adolescent↗
PubMed1975

Left ventricular ejection time measured by finger-tip plethysmography in healthy young Japanese. Its correction for heart rate.

Finger-tip plethysmograms were recorded photoelectrically on 200 young males and females each. The relation between the left ventricular ejection time (ET) and the preceding heart rate (HR) and a method for correcting ET for the heart rate were studied. The values calculated by the formula ET/S-S or ET/square root S-S varied with the HR, so these formulae cannot be used for correcting the ET for HR. Thus from the relationship between ET and HR, a formula for converting the measured ET to the ET at an HR OF 70, I.E. ETc, was deduced. ETc equals ET + HR - 70. This formula can be used for both sexes of Japanese juveniles and the values obtained by it can be directly compared, irrespective of the HR.

Adolescent↗