Search PubMed⌕ Search

Biomedical subjects

M Doi

Publications and source records attributed to M Doi.

At least 361 records · Page 20Linked to original sources
PubMed1984

Alcohol intake and hypertension among urban and rural Japanese populations.

A significant positive relationship was found between alcohol intake and blood pressure for men 40-69 years old living in urban Osaka (492 men) and in rural Akita (395 men), Japan, surveyed from 1975 to 1977. Both mean blood pressure and the prevalence of hypertension were related to alcohol intake in a graded fashion. Stepwise multiple regression also showed that both systolic and diastolic pressure were associated with alcohol intake independent of ponderosity index, serum cholesterol, triglycerides, hemoglobin, uric acid, smoking, and age. This cross-sectional study indicates a continuous--and not a threshold--relationship between alcohol and blood pressure, with the effect of even moderate consumption, e.g. 28-55 g per day (equivalent to about 2-4 U.S. drinks per day).

Adult↗
PubMed1983

Effects of high salt intake on hemodynamic responses to isometric exercise in normotensive subjects and in patients with essential hypertension.

Hemodynamic responses to isometric exercise were compared between 9 normotensive subjects (NT) and 16 patients with essential hypertension (EH) before and during high salt intake. The subjects were hospitalized and placed on a diet containing 6g of salt per day. Baseline hemodynamic studies were carried out on supine subjects before and 3 min after isometric exercise (30% of the maximal voluntary handgrip). Plasma concentration of norepinephrine (PNE) was also measured. Brachial arterial pressure was directly recorded and cardiac output (CO) was measured by the dye-dilution technique using a cuvette. The hemodynamic studies were repeated on the 5th day of a high salt diet (16g of salt per day). Retention of sodium was calculated on a daily basis by measuring the actual intake of sodium and 24-hour urinary excretion of sodium. Pressor responses to isometric exercise were significantly greater in the EH than in the NT group. Patterns of hemodynamic responses were different in the 2 groups, i.e., the elevation of arterial pressure was maintained by an increase in CO in the NTs, while it was maintained by increases in CO and total peripheral vascular resistance (TPR) in the EHs. The increase in CO was significantly greater in the NT than in the EH group [15 +/- 3 (mean +/- SE) vs 7 +/- 1%, p less than 0.05]. Although the salt loading reduced heart rate similarly in both groups (-9.0 +/- 2.1, p less than 0.01, in the NTs and -11.9 +/- 2.9%, p less than 0.01, in the EHs), the high salt diet did not significantly alter mean arterial pressure (MAP), CO or TPR in either group.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1982

Dietary intake and serum total cholesterol level: their relationship to different lifestyles in several Japanese populations.

Serum total cholesterol level and dietary intake were surveyed 1975--1977 in six Japanese population groups with different lifestyles, including groups in both rural (Akita and Kochi) and urban (Osaka) areas. Clerical workers in Osaka, who had the most westernized lifestyle of all the study groups, had the highest mean serum total cholesterol level (202 mg/dl for men ages 40--49 and 50--59 years), while farmers in Akita had the lowest mean serum total cholesterol level (163 mg/dl for men 40--49 years old, 159 mg/dl for men 50--59 years old, 165 mg/dl for men 60--69 years old). Nutrient intake data for mean ages 40--59 years showed 23% of calories from fat for clerical workers in Osaka, the highest among the study groups, whereas farmers in Akita showed a low level of 14%. The ratio of dietary polyunsaturated to saturated fatty acids was over 1.1 for all groups. Cholesterol intake was 339--487 mg/day. Total carbohydrate as a percentage of calories was 53--65%; 75--80% of carbohydrate energy was ingested from cereals. Sugar accounted for less than 3.5% of total calories. In the cross-group correlation analysis between dietary lipid intake and serum total cholesterol, a significant strong positive correlation was found between the dietary lipid factor (phi) of Keys et al. and the mean serum total cholesterol level. A weak but significant correlation was observed between the dietary lipid factor and serum total cholesterol for individual inhabitants of Osaka.

Adult↗
PubMed1982

Asparenomycins A, B and C, new carbapenem antibiotics. V. Inhibition of beta-lactamases.

Asparenomycins (ASMs) A, B and C inhibited a wide range of beta-lactamases including both cephalosporinases and penicillinases usually at concentrations less than 3 microM. On studying the mechanism of inhibition of beta-lactamases produced by Gram-negative bacteria by ASM A it was concluded that ASM A inhibited the beta-lactamases by acylating the enzymes. This conclusion was reached from the following observations. i) The inhibition was progressive with time. ii) The inhibitor formed stable complexes with the enzyme. iii) Before completing inhibition of one molecule of the enzyme, 1.8 molecules of the inhibitor were hydrolyzed.

Anti-Bacterial Agents↗
PubMed1981

The enzymatic synthesis of sepiapterin by chicken kidney preparations.

A chicken kidney preparation which catalyzes the conversion of D-erythro-dihydroneopterin triphosphate to dihydrobiopterin in the presences of Mg2+ and NADPH has been fractionated into three fractions, A2, A1, and B. Fraction A2 in the presence of Mg2+ catalyzes the conversion of D-erythro-dihydroneopterin triphosphate to an unknown intermediate designated compound X. Fraction A1 in the presence of NADPH catalyzes the conversion of compound X to sepiapterin. Fraction B, in the presence of NADPH, catalyzes the conversion of sepiapterin to dihydrobiopterin. Fraction B which is sepiapterin reductase was not studied any further. Fraction A1 is heat-labile and its molecular weight is estimated to be 3.0 x 10(4), whereas fraction A2 is heat-stable and its molecular weight, 7.7 x 10(4). Compound X is labile and its degradation products have been identified to be pterin and pyruvic acid. This information suggests that compound X is 6-(1,2-dioxopropyl)-7,8-dihydropterin.

Alcohol Oxidoreductases↗