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Biomedical subjects

M Corbett

Publications and source records attributed to M Corbett.

At least 73 records · Page 4Linked to original sources
PubMed1977

Radiographic changes in early rheumatoid disease.

We have studied the radiological features in 94 patients with early rheumatoid disease followed prospectively for 5 years. The changes appeared very early and occurred in up to 71-3% of patients. Erosive changes occurred in the feet much more commonly than in the hands and considerably earlier. Erosive changes were present before there was joint-space loss. Frequent x-ray examination of feet and hands in the first 2 years after presentation is required if we are to identify patients at risk for serious joint damage.

Arthritis, Rheumatoid↗
PubMed1977

Pain in the knee associated with osteoporosis of the patella.

Four patients, all of whom complained of pain in the knee, were found to have radiological evidence of osteoporosis particularly marked in the patella. In 3 a neurological lesion at the appropriate spinal segment was present, and the fourth patient, who was frankly hysterical, had an autonomic disturbance. If radiological porosis is isolated to the patella a distant cause such as nerve irritation should be sought.

Adult↗
PubMed1977

Relationship of radiological change to clinical outcome in rheumatoid arthritis.

Ninety-four patients with rheumatoid arthritis, seen within the first year after onset, have been followed prospectively with annual radiographs for a mean 63-1 months. An erosive arthropathy occurred in 72. The severity of the erosive changes showed a significant correlation with eventual clinical outcome. It is possible to predict a favourable outcome in those patients whose erosive changes become static at an early stage in the disease.

Arthritis, Rheumatoid↗
PubMed1976

Extra-articular features in early rheumatoid disease.

One hundred and two patients who presented with rheumatoid disease within the first year of onset were studied prospectively every four months for a mean 4.5 years to assess the incidence of extra-articular features. The features that seemed to be common in the early stages included hand-muscle wasting, carpal tunnel syndrome, lymphadenopathy, non-specific ankle swelling, and rheumatoid nodules, and to a lesser extent hepatomegaly, being underweight, conjunctivitis, skin transparency, and a palpable thyroid gland. Those features which seldom occurred early included scleromalacia, temporal artery inolvement, salivary gland enlargement, distal-motor neuropathy, splenomegaly, digital vasculitis, and pulmonary and cardiac complications. Being underweight indicated a significantly more severe outcome.

Adult↗
PubMed1976

Prognostic value of early features in rheumatoid disease.

Extensive data on 102 patients who presented with rheumatoid disease within a year of onset were gathered by a prospective study to assess the prognostic value of early features. Outcome was evaluated at a mean 4-5 years from onset on the basis of functional grade, extent of joint disease, early morning stiffness, and grip strength. Twenty-six patients improved, 14 pursued a mild steady course, and 62 had a persistently severe or deteriorating condition. The features recorded at the first visit were correlated with outcome. Those indicating a poor prognosis were: older age at onset, being underweight, poor grip strength, many affected joints, involvement of wrist or metatarsophalangeal joints, poor functional status, fulfilment of many of the American Rheumatism Association criteria for rheumatoid disease, raised erythrocyte sedimentation rate, seropositivity on sheep cell agglutination or latex tests, low haemoglobin level, raised blood urea level, and early erosions on x-ray films.

Age Factors↗
PubMed1976

Incidence of joint involvement in early rheumatoid arthritis.

The frequency of joint involvement is described in 102 patients seen within one year of onset of rheumatoid arthritis. The joints most commonly affected were metacarpophalangeal, proximal interphalangeal and wrists, followed by metatarsophalangeal and shoulders. The least commonly affected were the hips and spine. Temporomandibular and cervical spine involvement often occurred even in these early stages. Where there was unilateral involvement of corresponding joints there was a marked tendency for one side of the body to be more often affected. The arthritis was predominantly peripheral. There was a marked gradation of frequency in the small joints of the hands. The patients were followed prospectively for a mean 4.5 years and outcome assessed. An eventually more severe disease was associated with early writst and metatarsophalangeal joint involvement.

Adult↗
PubMed1976

Early rheumatoid disease. I. Onset.

We describe features with onset in 102 patients seen within the first year of rheumatoid disease. The male:female ratio was approximately 3:4, suggesting a near equal sex incidence at onset. The disease started more often in the colder months and was usually insodious, symmetrical, and involved the upper limbs. The patients were followed prospectively and outcome was assessed after a mean of 4.5 years. Older patients fared worse and there was a trend for a poorer prognosis to be indicated by an insidious onset and early progression to symmetrical involvement.

Adult↗
PubMed1976

Early rheumatoid disease. II. Patterns of joint involvement.

Data from the first research clinic visit (Fleming and others, 1976) have been subjected to factor analysis to identify early patterns of joint involvement. Nine patterns emerged. Two patterns, if present early, were found to have prognostic significance. An eventually more severe disease was associated with a pattern of large joint involvement (shoulder, elbow, wrist, knee) and a pattern based on metatarsophalangeal joints I and III.

Adult↗
PubMed1970

Comparison between local injections of silicone oil and hydrocortisone acetate in chronic arthritis.

One of three preparations-silicone oil, hydrocortisone acetate, and hydrocortisone acetate plus saline-was injected into 22 osteoarthritic and 49 rheumatoid knees. Silicone injected into stiff, dry, grating knees which were the site of chronic arthritis did not promote better movement than did hydrocortisone alone. Hydrocortisone plus saline, however, appeared to be more effective than silicone or hydrocortisone alone in increasing movement in rheumatoid knees. The maximum increase in movement was found to occur three weeks after each of the three different injection preparations.

Adult↗