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Biomedical subjects

M Corbett

Publications and source records attributed to M Corbett.

At least 55 records · Page 3Linked to original sources
PubMed1983

Avascular necrosis of bone complicating corticosteroid replacement therapy.

Two patients who developed widespread severe avascular necrosis of bone while on steroid replacement therapy are described. One, a diabetic, underwent yttrium-90 pituitary ablation for retinopathy and developed avascular necrosis within 18 months of starting prednisolone. The other, who had Addison's disease, developed avascular necrosis within 14 months of starting cortisol replacement therapy. Both cases came to bilateral total hip replacement.

Addison Disease↗
PubMed1983

Prospective study of the radiological changes in hands, feet, and cervical spine in adult rheumatoid disease.

Annual radiographs of hands, feet, and cervical spine were taken in 100 patients with rheumatoid arthritis from the first year of disease for a mean follow-up period of 9.5 years. Seventy-six patients developed peripheral erosive disease and 54 developed rheumatoid changes of the cervical spine, of whom 34 (63%) had subluxations. The severity of rheumatoid neck damage correlated strongly with the severity of peripheral erosive disease (p = 0.002). Cervical subluxation was more likely to occur in patients with erosions of the hands and feet which deteriorated progressively with time (p = 0.018). The timing and severity of cervical subluxation coincided with the progression of peripheral erosive disease in 26 of these 34 patients (76.5%). The other 8 patients with cervical subluxation (23.5%) had none or only mild peripheral erosions, but their subluxations did not progress with time. There were 9 patients with marked cervical subluxations which deteriorated relentlessly, and they all also had severe progressive erosive disease of the hands and feet. One of these patients developed a cervical myelopathy, and 2 other patients with normal neurological signs had upper cervical fusions performed for severe occipital headache. This small group of rheumatoid patients who are at risk of developing cervical myelopathy cannot be predicted with certainty, but can be selected out at an early stage by performing regular radiographs of hands, feet, and cervical spine.

Arthritis, Rheumatoid↗
PubMed1982

Results of a modified Putti-Platt operation for recurrent shoulder dislocations and subluxations.

In 78 consecutive cases of a modified Putti-Platt operation using an anterior shoulder incision, only on recurrent dislocation occurred in a 19-year-old male athlete who suffered an insulin seizure. All other patients have returned to athletic activity. This study indicates that external rotation is greater if measured with the arm at 90 degrees of abduction. Inasmuch as this is the more functional position for the arm, measurements to determine limitation of shoulder rotation should be done in this position. Results show that there is a definite individual variation in external rotation of the shoulder. The Putti-Platt operation limits external rotation by 12 degrees to 19 degrees as measured at 90 degrees of abduction. This however, has not been a functional problem in any of our patients. The modified Putti-Platt operation is a sound, surgical procedure that gives excellent functional results in an athletic population.

Adolescent↗
PubMed1981

A prospective study of the radiological changes in the cervical spine in early rheumatoid disease.

The cervical spine radiographs of 100 patients with early rheumatoid disease were studied annually, on a prospective basis, for a mean follow-up period of 7 years 2 months. Atlantoaxial subluxation developed in 12 patients. The subluxation was more frequent in females, more severe in patients with progressive, seropositive, erosive rheumatoid disease, and more marked in patients treated with oral corticosteroids. Subaxial subluxation, affecting upper cervical disc levels, occurred in a further 20 patients. Three patients developed vertical subluxation. The mobility of the cervical spine affects the degree of subluxation achieved, and when assessing serial films for subluxation it may be necessary to measure the cervical spine flexion before deciding whether subluxation has progressed or not. Over 80% of the patients with subluxation developed the first evidence of subluxation within 2 years of disease onset. Subluxation in the cervical spine is not, therefore, a late complication of rheumatoid disease. During the follow-up period none of the patients developed neurological signs.

Arthritis, Rheumatoid↗
PubMed1980

Increased incidence of faecal Klebsiella pneumoniae in patients with HLA B7 CREG antigen and men with rheumatoid arthritis.

In a study of the carriage of faecal Klebsiella pneumoniae in 106 patients with rheumatoid arthritis the incidence of carriage was higher in men (28%) than women (14%) (p < 0.001) and klebsiellae were isolated on two or more occasions from a higher proportion of men than women (p < 0.002). The incidence of carriage was increased among patients with rheumatoid arthritis who had B7 cross-reacting (B7 CREG) antigens (32% v 13%--p < 0.001). Carriage of klebsiellae was not associated with clinical disease activity, raised erythrocyte sedimentation rate, drug treatment, or the presence of HLA Dw4 or DRw4 or both. Thus the carriage and prevalence of faecal Klebsiella pneumoniae appear to be partly determined by the sex and HLA state of the host.

Arthritis, Rheumatoid↗
PubMed1980

The clinical assessment of joint inflammatory activity in rheumatoid arthritis related to radiological progression.

A simple clinical method for the assessment of joint disease activity is described, and analysed with respect to radiological progression of erosive disease. Ninety-four patients with rheumatoid arthritis attending a special research clinic as part of a prospective study were studied over a three-year period. A significant correlation was found between clinical activity, assessed at intervals of four months, and progressive erosive disease but not with juxta-articular osteoporosis. This clinical method compares favourably with a modification of the articular index described by the Cooperating Clinics of North America.

Arthritis, Rheumatoid↗
PubMed1980

Gold in psoriatic arthopathy.

It has been suggested that gold is not effective in psoriatic arthropathy. We did not agree and therefore did a retrospective study of 98 patients. Gold had been given to 27 and was effective in 22, 14 of whom are still receiving it. The incidence of side effects was low and comparable to those in rheumatoid arthritis.

Arthritis↗
PubMed1979

Case report 85.

Explore the source record for details and available documents.

Adult↗
PubMed1979

The production of prostaglandins in response to experimentally induced osteomyelitis in rabbits.

Osteomyelitis was induced in the tibiae of rabbits by injection of staphylococcus aureus and sodium tetradecylsulphate (STD); additional rabbits were injected with STD alone. Confirmation of osteomyelitis was based on positive culture of the same phage type bacteria from the tibiae and on the characteristic radiographical and histological appearance of osteomyelitis. Only tibiae which proved to be infected by the above criteria showed significantly increased in vitro release and content of Prostaglandin E and Prostaglandin F2 alpha compared with tibiae injected with STD (P less than 0.05). After two weeks infection, infected tibiae released nine times more Prostaglandin E and five times more Prostaglandin F2 alpha than tibiae injected with STD alone. After four weeks infection, infected tibiae released less Prostaglandin E (P less than 0.05) than after two weeks infection but the release of Prostaglandin F2 alpha was similar. The production of large amounts of prostaglandins by bones in response to infection may be the cause of the rapid bone resorption and sequester formation observed in osteomyelitis.

Animals↗
PubMed1979

Changes in load bearing in the rheumatoid foot.

A study of peak force exerted under areas of the foot was made in 27 patients with rheumatoid disease and in 30 normal persons. Patients were found to exert considerably less force under their toes and under the first metatarsal head and more force under the 3 outer metatarsal heads. It was possible to correlate these changes with increasing clinical and radiological severity.

Adult↗