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Biomedical subjects

M Cooke

Publications and source records attributed to M Cooke.

At least 109 records · Page 6Linked to original sources

Women doctors in urban general practice: the patients.

A large study from a representative sample of general practitioners in Manchester showed that women doctors saw more women patients than men doctors, especially in the childbearing age group. They saw a similar range of diagnoses as men doctors, though they saw more women patients for cervical smears, contraception, and breast disorders. Preventive health care may not be adequately provided for these in practices without a woman partner.

Adolescent↗

Women doctors in urban general practice: the doctors.

A large study of general practitioners in Manchester showed that women doctors were younger than men doctors, and few were single handed or worked in deprived inner city areas. They had closely similar patterns of care to their male colleagues, and although they worked slightly fewer hours in surgery, they had almost identical consultation times per patient. Women general practitioners were less active in politics and education than men.

Age Factors↗

Area variations in the process of care in urban general practice.

One hundred and eighty three practitioners collected data on 110 000 consultations. Case mix and pattern of care are compared for doctors practising in different urban areas. Inner city areas are compared with outer areas and the most deprived with the most affluent. Case mix varies slightly between areas, but there are no systematic differences in the pattern of care, which is equally variable in different areas. The stereotype of inner city general practice is not confirmed.

Adult↗

Improved method for the determination of chlorhexidine in urine.

A high-performance liquid chromatographic method is described which is suitable for the determination of the common antiseptic chlorhexidine in urine. The method employs Sep-Pak cartridges to remove chlorhexidine from the urine matrix. Chromatographic separation was achieved on a C18 reversed-phase column using a mobile phase of methanol-20 mM sodium acetate solution (60:40) adjusted to pH 5 with glacial acetic acid. An ion-pair agent (pentadecafluorooctanoic acid) was used at a concentration of 100 micrograms ml-1 X 3-Bromobenzophenone was used as chromatographic standard (kappa' = 4.0). 4-Bromobenzophenone (kappa' = 3.9) or dibenzal hydrazine (kappa' = 4.4) may also be used. A series of urine samples was analysed and no interferences were observed. The method is simple and rapid with a total analysis time of ca. 30 min.

Chemical Phenomena↗

Assessment by attending physicians of a seminar method to improve clinical teaching.

The authors in this article present assessments by attending physicians of a seminar method to improve clinical teaching. An experimental study was conducted to determine whether or not the seminar method (a) is perceived by attending physicians as beneficial, (b) modifies the physicians' attitudes toward teaching, (c) enables attending physicians to define needed teaching changes, (d) motivates them to improve their teaching performance, and (e) is perceived as having long-term benefits. Forty-six inpatient attending physicians from four California institutions participated in the study. The physicians were randomly assigned to an experimental group which attended a seminar on clinical teaching or to a control group which received no such intervention. Questionnaires completed by the physicians indicated that the teachers who experienced the seminar method perceived it as beneficial, improved their attitudes toward clinical teaching, determined needed teaching changes, attempted to implement new teaching approaches, and perceived long-term benefits.

California↗

Diagnosis and outcome of bowel infarction on an acute medical service.

Twenty patients with surgically or pathologically documented bowel infarction are compared with seven patients who were believed to have bowel infarction but had negative findings at laparotomy. The presentation of verified bowel infarction was nonspecific; abdominal pain, tenderness, and distension were the most common, occurring in 15 patients. No physical finding or laboratory test distinguished bowel infarction from mimicking conditions. Patients in both groups had an extremely poor prognosis. An approach to management is suggested.

Abdomen, Acute↗

Rapid determination of DDT and related compounds in soils via carbon skeleton gas chromatography-mass spectrometry.

The levels of DDT and related compounds in soil samples from an apple orchard have been determined. Extraction of residues was achieved by cyclic steam extraction and by conventional solvent extraction methods allowing comparison of the two methods. Determination of the organochlorine residues present in the extracts was performed by gas-liquid chromatography-electron-capture detection and by carbon skeleton gas chromatograph-mass spectrometry. Excellent agreement between the two determination techniques was achieved. Prior to application of p,p'-DDT, a value of approximately 0.4 ppm was obtained for Delta DDT in the soil. The major component of this total was DDE. After spraying the apple trees with technical grade, p,p'-DDT, Delta DDT for the soil rose to 0.6 ppm. This increase was due to translocation of p,p'-DDT from the trees.

DDT↗

Rapid assay for theophylline in clinical samples by reversed-phase high-performance liquid chromatography.

A fast, sensitive and highly specific method for the determination of theophylline in human serum is reported. Using a C18-bonded reversed-phase column with an acetonitrile-acetate buffer mobile phase theophylline is completely resolved not only from other dietary xanthines and their metabolites but also from co-administered drugs such as paracetamol and phenobarbitone. Use of beta-hydroxyethyltheophylline as internal standard allows a within batch precision of 2.0% and a between batch variation of 3.0%. Factors involved in the development of the method and its performance are discussed.

Asthma↗