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Biomedical subjects

M C Smith

Publications and source records attributed to M C Smith.

At least 343 records · Page 19Linked to original sources
PubMed1978

Some clinical aspects of caprine reproduction.

Several clinical reproductive problems in the female dairy goat are considered, including estrus detection, artificial insemination, pregnancy diagnosis, abortions, and periparturient difficulties. Sexual behavior of the buck, onset of puberty, techniques for semen collection and evaluation, the production of teaser animals, and methods of castration are also discussed. Recognition of the intersex goat, which may have a masculine, feminine, or intermediate phenotype, is necessary in herds where naturally polled animals are bred.

Abortion, Veterinary↗
PubMed1978

Physician use and evaluation of a hospital-based drug information center.

The use of a hospital-based information center by physicians was investigated. A questionnaire was used to gather information from physicians using the services of the center. The study was conducted over a six-month period. Of the 126 questionnaires distributed, 115 (91.1%) were completed and returned. The number of physicians studied was 100. The five categories of drug information most frequently requested involved adverse reactions, dosage, therapeutic use, availability and toxicity. Physicians used information most frequently for purposes of direct patient care. Evaluations of the quality, accuracy and quantity of information provided by the center were high. Physicians using information for purposes of direct patient care felt the information was clinically significant. Although certain inadequacies were identified, it was concluded that the center serves as a reliable source of comprehensive and accurate drug information for physicians.

Attitude of Health Personnel↗
PubMed1977

Mastitis and other diseases of the goat's udder.

Udder problems of modern dairy goats are similar to those seen in dairy cows. Anomalies of the goat's udder and teats are common, and many may be hereditary. Skin diseases of the udder include viral infections, mange, sunburn, wounds, and staphylococcal dermatitis. There are numerous known causes of caprine mastitis. These include streptococci, hemolytic and nonhemolytic staphylococci, corynebacteria, and mycoplasmas. Diagnosis of mastitis in goats is often difficult, as the udder secretion may remain grossly normal and somatic cell counts in nonmastitic goats are higher than the recognized normal range for cows. The importance of nonhemolytic staphylococcal cultures remains uncertain. Nonhemolytic staphylococci were isolated at the New York State Mastitis Laboratory from 30% of normal halves and from 22% of halves of udders from goats with assorted clinical problems. Treatment and prophylaxis of caprine mastitis closely parallel the standard technique recommended for bovine mastitis.

Animals↗
PubMed1977

Skylab nutritional studies.

Precise nutritional specifications arising from both physiological and experimental requirements necessitated a comprehensive study of the chemical composition of the Skylab food supply. Each of the approximately seventy different food items was analyzed for digestible and non-digestible carbohydrate, and for protein, amino acids, fat, fatty acids, vitamins and minerals. Menus were formulated to provide at least the National Research Council's Recommended Dietary Allowance of all essential nutrients and, in addition, to provide constant daily intakes of calcium, phosphorus, magnesium, sodium, potassium and protein. In general, the crew members adhered to their programmed menus. The ability to swallow and digest food was unaffected by prolonged weightlessness. Taste acuity also appeared to be undiminished in flight. The bone and muscle changes which occurred in previous flights were more pronounced in Skylab. It is concluded that these changes did not develop as a result of nutritional deficit. If such changes are nutritionally related, they point to the existence of nutritional requirements in weightlessness which differ quantitatively from those observed on earth.

Adaptation, Physiological↗
PubMed1977

Drug product advertising and prescribing: a review of the evidence.

A review of the effect of advertising drug products in medical journals on the prescribing of drugs is presented. The scope of advertisiig, the content of advertising, the latent effects of advertising, the effects of advertising on prescribing, and the social costs and benefits of advertising are discussed. Advertising for antibiotic and psychotropic drug products is reviewed in some detail. It is concluded that there is inconclusive evidence that the pharmaceutical industry, through journal advertising, is persuading physicians to prescribe drugs too often or unwisely, or both. It is suggested that pharmacists study the information needs of health care practioners and provide good drug information services.

Advertising↗
PubMed1977

Nutrition and responses to zero gravity.

Prior to the Mercury program, extensive efforts were undertaken to find ways of minimizing the mass of in-flight food systems. Such efforts were directed to the use of dehydrated, energy-dense foodstuffs and to the possibilities of nutrient recyclization. As the space program became a reality, nutritional scientists were more concerned with the mechanics of food consumption in weightless flight and with the problems of structuring convention foods in a way that would facilitate their use in weightlessness. It soon became clear that there was no substantial impediment to normal gastrointestinal function in flight, and attention was shifted to more subtle metabolic phenomenons. It became apparent that slight changes occurred in skeletal density, muscle mass, and overall body composition. Recognition of these changes led to extensive ground-based simulation studies and carefully designed in-flight experiments. Data are presented on the requirements for metabolic energy in flight and on the losses that have been observed in the major elemental constituents of the body. It is concluded that convincing evidence is not yet avialable on the ability of man to adapt to long-term weightless flight. Although his nutritional requirements are qualitatively similar during flight, the sophisticated manipulation of nutrient profiles shows promise of counteracting some of the deteriorative processes that are known to occur.

Aerospace Medicine↗
PubMed1976

Methyldopa and propranolol or practolol in moderate hypertension.

The effect of a low dose of methyldopa combined with (a) a non-selective and (b) a selective beta-adrenoceptor antagonist was studied in a double-blind crossover trial in 24 carefully selected patients with moderate hypertension (mean initial lying blood pressure 189/117 mm Hg). Each patient received methyldopa 750 mg/day, propranolol 240 mg/day, practolol 600 mg/day, methyldopa 750 mg/day combined with propranolol 240 mg/day, methyldopa 750 mg/day combined with practolol 600 mg/day, and placebo for four weeks each according to a random sequence. After four weeks of therapy the most effective treatment, methyldopa combined with propranolol, reduced lying and standing blood pressures by 36-5/21-4 mm Hg and 44-7/25 mm Hg respectively. Thic combination had similar effects to those of the combination of methyldopa with the cardioselective agent practolol except that it reduced lying diastolic pressure further. The combination was more effective than either treatment alone. No significant differences were found between the effects of propranolol, practolol, or methyldopa at the doses used.

Adult↗
PubMed1976

Propranolol in hypertension: a dose-response study.

The effect of propranolol was studied in a double-blind crossover trial in 24 carefully selected hypertensive outpatients. Each patient received propranolol 60 mg/day, 120 mg/day, 240 mg/day, and placebo for four weeks each according to a randomised sequence. Propranolol 60 mg/day was no better than placebo in reducing blood pressure. The effects of propranolol 120 mg/day and 240 mg/day were not significantly different. Both doses reduced lying blood pressure by about 20/10 mm Hg from an initial level of 173/104 mm Hg. No difference was detected between the effects of the different doses of propranolol and placebo on weight or on the occurrence of adverse reactions.

Adult↗