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Biomedical subjects

M C Anderson

Publications and source records attributed to M C Anderson.

At least 127 records · Page 7Linked to original sources
PubMed1980

Cervical crypt involvement by intraepithelial neoplasia.

Knowledge of the frequency and extent of crypt involvement by cervical intraepithelial neoplasia (CIN) is important when treatment by electrodiathermy, cryosurgery, or the laser is considered. Three hundred forty-three therapeutic cone biopsies carried out at The Samaritan Hospital for Women, London, have been reviewed histologically. Measurements were made of the deepest crypt in each specimen and of the deepest crypt that contained CIN. The mean depth of involved crypts was 1.24 mm, and the mean depth of uninvolved crypts was 3.38 mm. Thus, destruction of tissue to a depth of 2.92 mm (mean + 1.96 SD) would eradicate all involved crypts in 95% of patients, whereas destruction to a depth of 3.80 mm would eradicate 99.7% (mean + 3 SD). There is also an increase in the depth of crypt involvement with increasing age, but the differences between the age groups are not statistically significant.

Adolescent↗
PubMed1979

A report of the histological features in 12 cases of gonadoblastoma.

This report deals with 12 cases of gonadoblastoma submitted to the Ovarian Tumour Panel of the Royal College of Obstetricians and Gynaecologists. These tumours are found in children and young adults. Children may present with obvious genital malformation, retarded growth or precocious puberty. In adults the main compliant is amenorrhoea but sometimes there is associated masculinization. Histologically the gonadoblastoma has a distinctive structure, easily recognized in most instances. The most important feature is the instability of the germ cells in these tumours. Nine of these cases showed an associated dysgerminoma, bilateral in 4. In any cases of suspected gonadal dysgenesis presumptive evidence of diagnosis is suggested by the presence of a Y chromosome, raised gonadotrophin output and pelvic calcification on X-ray examination. At operation, streak tissue on both sides must be removed since these tumours are frequently microscopic in size. For the same reason the tissue removed should be serially sectioned.

Adolescent↗
PubMed1979

Meckel's diverticulum of the proximal jejunum.

There are no well-substantiated reports, to our knowledge of a Meckel's diverticulum arising outside the limits of the terminal ileum. We saw a diverticulum located in the proximal jejunum that fulfilled the anatomic and histologic criteria for the diagnosis of a Meckel's diverticulum. This was an incidental finding during the treatment of a sliding esophageal hiatus hernia and caused no apparent difficulty to the patient.

Gastroesophageal Reflux↗
PubMed1979

Pancreatic enzyme levels in bile of patients with extrahepatic biliary tract disease.

A total of ninety three patients with biliary tract disease were studied to determine the concentration of the pancreatic enzymes, amylase and lipase, in bile obtained from the gallbladder and/or common bile duct. Of seventy gallbladder bile samples, amylase levels were higher than actual or predicted serum levels in 87 per cent, while bile lipase were higher than serum lipase values in 66 per cent. Bile obtained from the common bile duct had enzyme concentrations which fluctuated from values similar to those in serum to remarkably high levels. This suggests that pancreatic enzymes enter the biliary system through a common terminal ampulla which is known to exist in 60 to 90 per cent of human subjects. The premise is advanced that pancreatic enzymes may initiate inflammatory changes in the gallbladder and could play a role in gallstone formation by altering the constituents which maintain cholesterol in a soluble state. Biliary reflux of pancreatic enzymes could play a role in the pathogenesis of some cases of cholecystitis can cholelithiasis.

Ampulla of Vater↗
PubMed1979

Pseudocyst of the head of the pancreas: relationship to the duct of Santorini.

A series of 14 patients with chronic alcoholic pancreatitis is presented which illustrates that cysts originating in the superior segment of the head of the pancreas communicate with the duct of Santorini which normally drains this area of the gland. Cysts in this location do not communicate with the major pancreatic duct (Wirsung) in most instances, and therefore may be overlooked in the standard retrograde drainage procedures employed to relieve pancreatic exocrine obstruction.

Adult↗
PubMed1978

Endometrial assessment with Isaacs cell sampler.

The value of the Isaacs endometrial cell sampler in the cytologic assessment of the endometrium was studied in 121 unanaesthetised patients aged over 40. Satisfactory aspirates for cytological diagnosis of endometrial state were obtained in 111 patients (91%) whereas endometrial specimens for histological diagnosis were obtained in only 89 patients (79%). In only four out of 83 cases were there diagnostic discrepancies between the aspirates and the curettings. It is concluded that the technique is safe, quick, comfortable, and reliable for assessing endometrial state. It should therefore prove valuable for screening, particularly in the management of menopausal women requiring oestrogen treatment.

Adult↗
PubMed1978

Education as a hidden cost in ambulatory care.

Since nearly a quarter of this nation's hospitals' outpatient and emergency rooms engage in medical education, it is of critical importance for administrators to determine the extent to which medical training influences the operational costs and efficiency of patient care for those services in their facilities. A computer simulation model has been developed at a midwest adult medical clinic to study the effects of ambulatory medical training on clinic operations. The model is capable of showing changes in the facility without disrupting the work flow and thus reduces the problems associated with long-term data collection. Various staffing patterns, both with and without medical training, were compared for the operational effects, patient convenience, and costs. The article offers probability distributions based on actual clinic experience. The research identifies and evaluates the trade-offs that must be considered when medical education is incorporated in an ambulatory program. Since both the faculty and students must take time away from direct patient care for consultation, more clinic time is required, causing staff costs to increase and patient care efficiency to decrease. The model demonstrates that when teaching loads increase, the faculty become less available to residents which results in resident inefficiency and longer patient waiting time. These operational consequences demonstrate the basic management problems of the need for balance between the demand for clinical teaching time and the demand for efficient service delivery in a solid ambulatory care/teaching program.

Adult↗
PubMed1978

Characterization of antigens from Aspergillus fumigatus. II. Fractionation and electrophoretic, immunologic, and biologic activity.

Mycelial extracts of Aspergillus fumigatus grown in completely synthetic medium were fractionated by precipitation with ammonium sulfate, by ion-exchange chromatography, and by gel filtration. The fractions were characterized chemically, by analytic polyacrylamide gel electrophoresis, and by tests for serologic and biologic activity. The distribution of the antigens in the fractions was determined by double diffusion in gel and fused-rocket immunoelectrophoresis. Activity greater than that of the parent mycelial extract serologically, in guinea pig skin tests, and in in vitro lymphocyte transformation was observed with one fraction that was found in the 75 per cent ammonium sulfate precipitable portion and was eluted early by gel filtration. Another ammonium sulfate-precipitable component and one that was not precipitable at 75 per cent ammonium sulfate, but was firmly bound by ion-exchange columns, was found to have activity equal to unfractionated mycelial extract. These fractions were also active by a radioallergosorbent test for IgE. A carbohydrate component comprising almost 40 per cent of mycelial extract was found to be devoid of any immunologic activity.

Animals↗
PubMed1977

Behavioral adaptation to fixed-interval and fixed-time food delivery in golden hamsters.

Food-deprived golden hamsters in a large enclosure received food every 30 sec contingent on lever pressing, or free while their behavior was continuously recorded in terms of an exhaustive classification of motor patterns. As with other species in other situations, behavior became organized into two main classes. One (terminal behaviors) increased in probability throughout interfood intervals; the other (interim behaviors) peaked earlier in interfood intervals. Which class an activity belonged to was independent of whether food was contingent on lever pressing. When food was omitted on some of the intervals (thwarting), the terminal activities began sooner in the next interval, and different interim activities changed in different ways. The interim activities did not appear to be schedule-induced in the usual sense. Rather, the hamsters left the area of the feeder when food was not due and engaged in activities they would normally perform in the experimental environment.

Journal Article↗