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Biomedical subjects

M C Anderson

Publications and source records attributed to M C Anderson.

At least 145 records · Page 8Linked to original sources
PubMed1975

Microcirculation of the normal and inflamed canine pancreas.

Pancreas of normal dogs and the inflamed gland of experimental pancreatitis were studied by intra-arterial injection of Microfil, a silicone-rubber compound especially suited for study of the microcirculation. Duodenal vasculature and lobular vessels of the pancreas were studied as were those supplying the duct. Inter-lobular vessels were well visualized in the normal pancreas and intralobular vessels formed a fine reticular pattern throughout the cleared lobules. A complex network of vessels in the pancreatic duct was observed using this technique, apparently derived from the interlobular vessels. The blood supply of each layer of the duodenum was evaluated. Intraductal trypsin injection produced focal areas of pancreatitis associated with edema, poor vascular filling and spastic changes of the lobular vessels. Extravasation of Microfil, although not apparent on normal specimens, was prominent in inflamed specimens and suggested vascular weakness and disruption. Pancreatic lobules adjacent to inflammatory areas showed definite evidence of dilatation. The inflamed pancreatic ducts were markedly edematous, thickned, and showed incomplete vascular filling. When the duodenum adjacent to pancreatitis was injected with Microfil, edema and vasoconstriction were especially prominent in the duodenal muscular layer.

Animals↗
PubMed1975

Gynandroblastoma of the ovary.

A gynandroblastoma of the ovary in a 17-year-old girl is reported. Primary amenorrhoea, hirsuties and slight clitoral enlargement were associated with the tumour and high levels of circulating testosterone were found. This is the first gynandroblastoma in which Reinke crystalloids have been identified in the Leydig cell component. The criteria for the diagnosis of this tumour and its histogenesis are discussed.

17-Hydroxycorticosteroids↗
PubMed1972

Hilar cell tumour of the ovary.

The case of a 42-year-old woman with virilization, hirsutes, and a high level of circulating testosterone is described. A hilar cell tumour of the ovary was found, the histological features of which were typical, with the presence of crystalloids of Reinke, hyaline bodies, lipid, and lipofuscin. Some areas showed appearances similar to those seen in ;adrenocortical cell' tumours. In common with other lipid cell tumours of the ovary, hilar cell tumours most probably arise from mesenchymal elements and the group should, therefore, be considered as a subdivision of the gonadal stromal (sex cord-mesenchymal) tumours.

Adult↗