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Biomedical subjects

M Brozman

Publications and source records attributed to M Brozman.

At least 73 records · Page 4Linked to original sources
PubMed1982

[Congenital defects of neurohypophysis with adrenal hypoplasia].

Congenital adrenal hypoplasia without expressive diencephalic malformation is rare. Autopsy findings in two newborn girls with hypoplasia of the neurohypophysis or aplasia of neurohypophysis combined with severe cortical adrenal hypoplasia, resp., are reported. The weight of both adrenals in the case with neurohypophyseal hypoplasia was 0,39 g, and in the case with aplasia of neurohypophysis it was 0,27 g. In both cases the adenohypophysis was poorly differentiated and the number of R and S cells was considerably reduced. In the case with aplasia of neurohypophysis, R cells were identified only by use of the immune fluorescence staining technique. Moderate hypoplasia and interstitial fibrosis were also found in thyroid gland and gonads. In both cases, the hypothalamic-pituitary connection, i.e., the infundibulum and pituitary portal system were missing and, consequently, the supply of secretion-stimulating hypothalamic substances to adenohypophysis via portal system was disturbed.

Adrenal Cortex↗
PubMed1981

A comparative study of the morphology of the systemic anaphylactic reaction (SAR) and the shock reaction induced by antigen-antibody complexes in rabbits.

Differences in the morphological picture of the systemic anaphylactic reaction (SAR), and of the shock reaction induced by antigen-antibody (ag-ab) complexes in rabbits, are described. In rabbits SAR is characterized by acute distension of the lungs, with oedematous swelling in the vicinity of bronchi and veins, intravascular stasis of basophils without degranulation or visible fixation of the inducing antigen, small clusters of blood platelets, leukostasis, minimal decomposition of neutrophil granulocytes and absence of circulating or fixed ag-ab complexes. The shock reaction induced by ag-ab complexes is characterized by acute distension of the lungs without bronchospasm, swelling of the vicinity of bronchi and veins, hyaline thrombi particularly in the pulmonary microcirculation, leukostasis, formation of antigen-antibody complexes and thrombocyte clusters in the microcirculation, and by phagocytosis of these complexes and thrombocytes by various cells.

Anaphylaxis↗
PubMed1980

Circadian ultrastructural changes in rat gastric parietal cells.

The ultrastructure of rat parietal cells of the gastric mucosa was investigated during the twenty-four hours of a day. Male rats were housed at ad libitum feeding under normal light conditions with dark night. The animals were sacrificed at 6.00 h, 12.00 h, 18.00 h and 24.00 h respectively, in groups of 5 animals after standard 24 hours of starvation. From this material the electronograms of 356 parietal cells (19% in 6.00 h, 26% in 12.00 h, 21% in 18.00 h and 34% in 24.00 h samples) were evaluated. Based on literary data, the parietal cells were specified as secreting parietal cells (S, 38% of the total), secreting parietal cells returning to resting state (SR, 18% of the total), resting parietal cells (R, 35% of the total) and resting parietal cells tending to early secreting state (RS, 9% of the total). Some types of parietal cells are statistically highly significantly (x2 = 130.9, p less than 0.001) unequally distributed during the circadian rhythm: S are less numerous at 6.00 h (2% of the total) and 12.00 h (4% of the total) than expected (7 and 10% respectively), and more numerous at 18.00 h (11% of the total) and 24.00 h (21% of the total) than expected (8 and 13% respectively). Conversely, R are more numerous in the morning (13 and 15% instead of 7 and 9% respectively) and less in evening samples (4 and 3% instead of 7 and 12% respectively). Distribution differences were proved statistically (x2-test) for all cell-cell and hour-hour combinations expect the combinations S-RS and 6.00 h to 12.00 h. The maximal differences in distribution were found to be between the amounts of S and R at 6.00 h and 24.00 h (x2 = 77.3, p less than 0.001) and at 12.00 h and 24.00 h (x2 = 69.3, p less than 0.001). Thus, a distinct circadian rhythm of parietal cells, especially as to their fine cell structures involved in acid production was demonstrated. The results render further evidence of the rhythmicity of gastric acid production in rats.

Animals↗
PubMed1980

Antigenicity restoration of formaldehyde-treated material with chymotrypsin.

In histological preparations commonly fixed in formaldehyde and embedded in paraffin which on immunofluorescent examination yielded results negative results or but very poor immunofluorescence, prominently positive results were obtained by chymotrypsin treatment on using the method of fluorescent antibodies. Corresponding results were also obtained in cryostat sections fixed for some min up to several days in formaldehyde so that immunofluorescence was completely negative. The positive immunofluorescent results indicate total or partial restoration of antigenicity of tissue proteins previously altered by formaldehyde.

Animals↗
PubMed1980

On morphology of anaphylactic reaction elicited by ferritin.

The differences between the systemic anaphylactic reaction (SAR) of guinea-pigs actively sensitized with ferritin and those guinea-pigs who were administered with ferritin-antiferritin complexes, which were of a clinically and macroscopically identical result, are described by means of methods of the morphologic examination. Except some details, SAR of guinea-pigs and rabbits elicited by ferritin possesses a similar morphological picture.

Anaphylaxis↗