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Biomedical subjects

M Akimoto

Publications and source records attributed to M Akimoto.

At least 253 records · Page 14Linked to original sources
PubMed1983

[Fracture of the penis: report of 10 cases and a review of 231 cases in Japan].

Ten cases of fracture of the penis were experienced between 1961 and 1981 at our Department. In all cases, the penis was swollen and distorted by a subcutaneous hematoma. No hemorrhagic discharge from urethra was seen. The patient's age was between 19 and 57 years. The causes of these fracture were coitus in 3 cases, manipulation in 4 cases (including one masturbation case), inverting in 2 cases, and the last case resulted from the patient's rolling over in bed. Surgical repair was performed on all patients. The causes, diagnosis, therapy and prognosis of 231 cases of fracture of the penis reported in the Japanese literature between 1934 and 1982 are reviewed.

Adult↗
PubMed1983

[Retroperitoneal lipoma: report of a case].

A case of retroperitoneal lipoma is reported. The patient came to our hospital with the complaint of an abdominal mass. The pathological finding was benign lipoma. The diagnosis, therapy and prognosis of 51 cases of the disease collected from the Japanese literature are reviewed.

Aged↗
PubMed1982

Congenital mesoblastic nephroma.

For more than a decade congenital mesoblastic nephroma of infancy has been recognized as an entity different from Wilms tumor in its clinical and histopathologic features. However, this tumor is sometimes confused with Wilms tumor and consequently, inadvertent and vigorous therapy compatible with that for Wilms tumor is given. we reviewed the literature and analyzed 90 cases of congenital mesoblastic nephroma in the English and Japanese literature. The importance of early and accurate histopathologic diagnosis of the resected specimen to avoid inappropriate post-operative therapy is emphasized, and the peculiar features of congenital mesoblastic nephroma are characterized.

Birth Weight↗
PubMed1982

[Effects of protein calorie intake on immuno- and chemotherapy].

Immuno-chemotherapeutic effect on growth of 81B mammary tumor was studied in syngeneic C3H/He mice fed diet with low (D) or normal (N) protein content. 1. 5-FU 20 mg/kg. was given intra-peritoneal daily for 3 weeks. The tumor volume ratio (T/C) was significantly reduced on day 14 in both N and D-group mice. However, all mice were dead 2 weeks after administration of 5-FU in D-group mice. 2. Immuno-potentiator OK-432 (50 KE/kg,) or Lentinan (5 mg/kg,) was given i.p. daily for 3 weeks. The 81B tumor growth was inhibited on day 14 in N-group mice. However, the tumor growth was paradoxically accelerated after administration of these agents in D-group mice. Augmentation of the natural killer cell activity was recognized in N-group mice treated with OK-432 or Lentinan, but no change was seen in D-group mice. 3. After administration of 5-FU, intra-tumoral concentration of 5-FU was higher in N-group mice than that of in D-group mice.

Animals↗
PubMed1981

Spectrophotometric analysis for fluorouracil in biological fluids.

Fluorouracil (5-fluorouracil; 5-FU) is a monoanion at pH = 10 and forms an ion-pair complex with a quaternary alkylammonium ion. De Leenheer and co-workers [2] reported that the ion-pair complexes might be quantitatively extracted from aqueous solutions into organic solvents, and they spectrophotometrically determined the concentration of 5-FU. But as their method used column chromatography, it was cumbersome and time-consuming. Here we present a more rapid chemical assay of 5-FU by modifying the principle of their method. The applicability of this method was shown by determining the plasma and tissue levels of 5-FU in mice.

Animals↗