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Biomedical subjects

M Akimoto

Publications and source records attributed to M Akimoto.

At least 271 records · Page 15Linked to original sources

Macrophages in prostatic fluid.

Non-specific esterase staining has been found useful in the detection of macrophages in prostatic fluid (PF). In the early stage of acute prostatitis most of the leucocytes in a smear of PF took up the stain, suggesting the dominant participation of macrophages in the inflammatory area in this stage of the disease. In chronic prostatitis, only a few leucocytes took up the stain. In female acute cystitis, none of the large numbers of leucocytes exhibited staining at any stage of the disease. The reason for this is still to be determined. Frozen sections of prostatic tissue from patients with chronic prostatitis revealed similar cells around the acini and these appeared to be the source of the macrophages which appeared in the PF.

Body Fluids↗

Serum somatomedin A in chronic renal failure.

The serum levels of somatomedin A, determined by radioreceptor assay, were significantly higher in 57 adult patients with chronic renal failure (X = 2.57 +/- 0.12 U/ml) than in healthy subjects (n = 131; X = 0.77 +/- 0.02 U/ml). A positive correlation was found between somatomedin A and creatinine levels (r = 0.33), but somatomedin A levels did not decrease after hemodialysis. A reduction was only observed after successful renal allografting. Immunoreactive somatomedin A was also found to be increased in patients with chronic renal failure (X = 2.61 +/- 0.21 U/ml), whereas low levels were obtained by the chick bioassay. However, after separating the inhibitory factors from the stimulatory factors by gel chromatography at neutral pH, uremic serum was shown to contain increased levels of somatomedin activity. Although all somatomedin A, determined by different techniques, was present in high molecular forms, the elution pattern differed from that seen in patients with acromegaly.

Adolescent↗

Comparative pressure-length-diameter relationships of neonatal and adult rabbit ureters.

Pressure-length-diameter relationships of neonatal and adult rabbit ureters were studied in vitro. The increase in diameter, in response to an intraluminal pressure load of 10, 20, and 40 g per cm2, was faster and greater in the neonate than in the adult. Incubation in norepinephrine decreased the diametral deformation of neonatal ureters but had little effect on deformation in the adult ureter. The in vitro neonatal rabbit ureter, thus, appears to be more compliant and more sensitive to norepinephrine than the adult ureter.

Animals↗

Congenital renal arteriovenous fistula: case report, review of Japanese literature and description of non-radical treatment.

A case of congenital arteriovenous fistula diagnosed by measuring the oxygen saturation difference of renal veins at the time of selective renal angiographic examination and a review of 38 relevant Japanese cases are reported. The English as well as the Japanese literature was reviewed. Treatment has consisted of partial nephrectomy, ligation of the branch artery supplying the fistula and intentional embolization of the arterial branches, feeding the shunt by catheter.

Aged↗

Linear straited vascular pattern: its implication on a renal angiogram clinical importance and pathologic verification.

A case of hypernephroma with neoplastic extension to the renal vein showing a characteristic linear striated vascular pattern on a renal angiogram is presented. A nephrectomy specimen was examined pathologically and angiographic correlation subsequently was inferred. Implication of this unusual pattern on the renal angiogram is emphasized through our experience and review of relevant literature in order to predict the prognosis and to prepare for radical treatment.

Adenocarcinoma↗

[Intracranial hemorrhage in an infant due to vitamin K deficiency --successful management of spontaneous intracerebral and subjural hematoma].

A one-month-old male infant with spontaneous intracerebral and subdural hematomas due to vitamin K deficiency was described. He was breastfed. Loose stools continued and began to contain blood. He had fever, vomiting and convulsion, and became drowsy. The blood studies showed anemia and hypoprothrombinemia. Left carotid angiograms revealed intracerebral and subdural hematomas. He was treated successfully by immediate operation and administration of vitamin K. 2) Vitamin K deficient hemorrhage beyond the immediate newborn period was discussed with reference in the literature. Three etiologic factors included, decreased vitamin K intake, decreased intestinal absorption of vitamin K and decreased production of vitamin K by colon bacteria. The most important factor of the three seemed to be low vitamin K intake. Intracranial hemorrhage was recognized in about one third of the cases in the literature. It was emphasized that vitamin K deficiency occurring beyond the immediate newborn period was very important as a cause of intracranial hemorrhage in infancy.

Cerebral Hemorrhage↗