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Biomedical subjects

M Akimoto

Publications and source records attributed to M Akimoto.

At least 235 records · Page 13Linked to original sources
PubMed1984

[Prevention of 5-FU induced toxicity in C3 H/HE mice with interferon or with interferon inducers (poly 1: C, OK-432, Lentinan)].

It is well known that all cell lines, normal as well as malignant, have a sensitivity to the growth-inhibitory effect of Interferon, or Interferon inducers. 5-FU is a widely used anticancer drug considered to be a cell cycle-specific agent. We speculated that the antiproliferative effect of Interferon or Interferon inducers might affect the activity of 5-FU and diminish the uncomfortable side-effects of this agent. Initially this experiment, we observed the mortality rate in mice after administration of 5-FU alone, or 5-FU plus Interferon (alpha inducers). We then carried out cytofluorometric observation of bone marrow cells, and finally studied the influence of Interferon (or inducers) on the anticancer effects of 5-FU against MM48 tumors in C3/He mice. Findings were as follow: 1) Administration of beta-type Interferon for 2 days, following the administration of a toxic dose (140 mg/kg/w) of 5-FU, revealed significant protection from mortality in C3H/He mice. This effect was also observed when Interferon inducers (Poly I: C, OK-432, Lentinan) were administered with 5-FU. Body weight loss was 10.4% at nadir in mice treated with 5-FU alone, while there was a body weight gain of 36.3% in mice treated with 5-FU plus Interferon. 2) Cytofluorometry of bone marrow cells obtained from mice femur at timed intervals after the administration of OK-432, or Lentinan indicated that these drugs inhibited the entry of cells into the S-phase, causing then to accumulated in the G0.G1-phase during the first 48 hours. 3) Histological findings of intestinal mucosa in mice showed prominent destruction after bolus injection of 350 mg/kg of 5-FU alone, while these findings were not observed in mice after the bolus injection of 350 mg/kg of 5-FU combined with Interferon. 4) The tumor volume ratio (T/C) was significantly reduced in the group treated with 5-FU alone as well as that treated with 5-FU combined with Interferon (or inducers) in C3H/He mice bearing MM48 tumors. All mice were dead about 2 weeks after administration of 5-FU alone, while all mice treated with 5-FU plus Interferon (or inducers) were alive in the same period. From these results, we speculate that Interferon, or Interferon inducers play an important role in the prevention of side effects of cell cycle-specific cytotoxic drugs like 5-FU, without decreasing their anticancer activity.

Animals↗
PubMed1984

[Case of immature teratoma of the testicle metastasizing as completely mature teratoma].

A case of immature teratoma of the testicle metastasizing as completely mature teratoma is presented. A 23-year-old man underwent right inguinal orchiectomy for an immature teratoma of the testicle on September 14, 1982. At retroperitoneal lymph node dissection, 12 lymph nodes were removed, all of which were negative for cancer. He was well until March 1983, when bloody sputum and left chest pain occurred. Since full lung tomography revealed two pulmonary nodules, he was treated with a course of VP-16 and three courses of vinblastine, bleomycin and CDDP. In September 1983, after completion of the combination chemo-therapy, the two pulmonary nodules were noticed to be slightly enlarging. A thoracotomy was scheduled to remove these nodules, since they were believed to be his only remaining tumors. Pathologic examination of the extirpated nodules disclosed completely benign teratoma. Mediastinal lymph nodes had no metastatic involvement histologically. It is our intention in this paper to emphasize, by means of several case reports, the frequently benign nature of these residual lesions and also to emphasize a recently recognized phenomenon--the apparent induction of benign teratomas by this intensive chemotherapy.

Adult↗
PubMed1984

[A case of renal carcinoma with bone metastasis, producing alpha-fetoprotein].

A 54-year-old man was admitted with the complaint of severe lumbago, pain in the right shoulder and difficulty in walking. Laboratory tests showed markedly increased alpha-fetoprotein (AFP) level (600 ng/ml) and tomography demonstrated osteolytic lesion of the 5th lumbar vertebra and right scapula. Needle biopsy of the 5th lumbar vertebra revealed only necrotic tissue pathologically. Liver scan and whole body CT did not show any abnormality except for a right renal mass. Hypervascular tumor at the lower pole of the right kidney was noted by IVP and selective renal angiography. No pulmonary metastasis was found. The patient underwent transabdominal right nephrectomy. He had a lowered level of AFP (300 ng/ml) on the 17th post operative day. AFP level dropped further to 100 ng/ml after administration of vinblastine and ifosfamide. Lumbago continued without improving, and the patient died at home 20 weeks after surgery due to general weakness. Although we did not perform radiological examination of gastro-intestinal tract or autopsy, we concluded that renal cancer and/or a metastatic lesion to bone produced AFP because of the following reasons. No other tumor was detected by liver scan, whole body CT, laboratory examinations, operation or clinical symptoms. The AFP level was lowered after nephrectomy, and further dropped with chemotherapy. A case of renal cancer with bone metastasis and without liver metastasis, producing AFP was reported in the Japanese literature in 1983.

Humans↗
PubMed1984

[Lipid-secreting carcinoma of the breast].

Lipid secreting carcinoma is a very rare tumor of the breast. This is regarded as a special type of breast carcinoma, which is characterized by abundant intracytoplasmic neutral lipid stained with Sudan IV. Two cases (75 and 42 year old females) of lipid secreting carcinoma of the breast are presented. No other reports of lipid secreting carcinoma have been available in the Japanese literature. In this report, the physical, mammographic and ultrasonographic diagnosis and pathological findings are described and discussed.

Adult↗
PubMed1984

[Phase II study of UFT for malignant tumors of urinary organs].

Phase II Study of UFT was performed in 59 patients with malignant tumors of urinary organs in 5 Cooperative Study Institutions. Forty-nine patients out of 59 were evaluable for response according to Koyama -Saito's criteria. Complete response (CR) was recorded in 7 patients, partial response (PR) in 3, minor response in 2, no change in 27 and progressive disease in 10, respectively. The overall response rate was 20.4%. The response classified in terms of tumor type was as follows: 4 CR and 2 PR of 23 patients with bladder tumor, response rate of 26.1%; 1 CR and 2 PR of 10 patients with renal tumor, response rate of 30.0%; 1 CR of 12 patients with prostatic tumor, response rate of 8.3%. Side effects occurred in 22 (41.5%) out of 53 patients. The high incidence was mainly concerned with GI toxicity such as anorexia (24.5%), nausea and vomiting (9.4%), general malaise (9.4%), diarrhea (3.8%) and stomatitis (3.8%), respectively. Renal function disorder was not induced, and marrow depression and hepatic function disorder occurred at low frequency (1 case each).

Adult↗
PubMed1984

[A case of a congenital unilateral multicystic kidney and a review of 126 cases in Japan].

A 3-year-old boy was admitted to our hospital with complaints of left flank mass and growth retardation. Examinations with IVP (Fig. 1), retrograde pyelography (Fig. 4) and cystoscopic examination (Fig. 3) showed a left nonopacified kidney, and right hydroureteronephrosis due to stenosis of the midureter. Two large cystic patterns were found in the left kidney by ultrasonic scanning tomography (Fig. 2); and, the left kidney was found to be occupied by a round and homogeneously low density mass by CT scanning (Fig. 6). The left renal artery was not demonstrated on the aortogram (Fig. 5). The patient was diagnosed to have a left congenital unilateral multicystic kidney, and laparotomy was performed. The left kidney was easily removed, and the part with stenosis in the right ureter was removed, then end-to-end anastomosis was performed. Grossly, two large cysts (upper and lower part) and connective tissues were found in the left kidney (Fig. 7), and the vessels of the renal pedicle were filiform. No luminal formation of the renal pelvis or ureter was found. The epithelium of the cyst wall (Fig. 8) was deciduated leaving the connective tissue and smooth muscle, as shown by the histological examination. Histological examination of the parenchymal tissue (Fig. 9) between the two cysts showed primitive glomeruli and renal tubules among abundant connective tissue, but no cartilage tissue. Statistic examination and discussion have been made of 126 cases of congenital multicystic kidney reported in Japan.

Adolescent↗
PubMed1984

[Metastatic ureteral tumor from the digestive organ: a case report].

A 63-year-old woman admitted because of a right non-visualizing kidney. Right ureteral tumor was clinically diagnosed by routine examinations. Pathological finding after right nephroureterectomy and partial cystectomy revealed adenocarcinoma of the ureter. She also had a history of gastrectomy for gastric cancer 4 years before. Metastatic adenocarcinoma of the right ureter from the stomach was the final diagnosis made after the pathological comparison of the two specimens. Thirty nine cases of metastatic ureteral tumor from the digestive organs were reported in Japan. The autopsy suggests that metastatic ureteral tumors occur more often than we may expect and as metastatic and invasive ureteral tumors from digestive organ, are often confused, the criteria to distinguish between them must be established.

Adenocarcinoma↗
PubMed1984

[Nonfunctioning adrenal cortical adenoma: a case report].

A case of nonfunctioning adrenal cortical adenoma is presented. A 56-year-old woman was admitted with the chief complaint of asymptomatic microscopic hematuria. Adrenal tumor was found accidentally by computed tomography scan during evaluation for hematuria. A venogram and adrenal scan confirmed left adrenal neoplasm. Endocrine studies were normal. Surgical extirpation was performed and pathological examination revealed 2.2 X 2.0 X 2.0 cm left adrenal cortical adenoma. Reports of nonfunctioning adrenal cortical adenoma in the Japanese literature were reviewed and a discussion was made on this rare condition.

Adenoma↗
PubMed1984

[Resection of solitary pulmonary cancer metastatic from renal cell carcinoma: a case report].

A 59-year-old man underwent right transabdominal nephrectomy for renal cell carcinoma on March 16, 1976. Full-lung tomography revealed an oval solitary shadow (11 by 14 mm) in the left upper lung field in February, 1983. Since there was no evidence of metastatic disease elsewhere in his body, thoracotomy and wedge resection of this nodule was performed. Histologically this nodule was found to be clear cell carcinoma. This patient has been well without recurrence for these 15 months. Significance and necessity of excision of metastatic nodules from renal cell carcinoma are stressed.

Adenocarcinoma↗
PubMed1984

[Ectopic ureterocele: a case report].

A case of ectopic ureterocele is reported. A 2-year-old girl was admitted for recurrent episode of urinary tract infection associated with fever. IVP showed bilateral duplex kidney, although no excretion of dye was noted from the right upper kidney. IVP also revealed a large filling defect at the bladder neck which was diagnosed as ureterocele by cystoscopy. Cystography demonstrated VUR to the right lower kidney. A complete duplication of ureter with ectopic ureterocele on the right, and incomplete duplication of ureter on the left were found at operation. She underwent complete removal of the ectopic ureterocele and reimplantation of the right two ureters. Her postoperative course was uneventful, post-operative IVP revealed improvement of pyelography of the right lower kidney and cystography revealed no VUR.

Child, Preschool↗
PubMed1984

[A case of testicular tumor with uncommon clinical course: testicular lesion that was initially not palpable led to a wrong diagnosis of huge retroperitoneal hematoma due to trauma].

A case of testicular tumor with uncommon clinical course is presented. Although the patient underwent abdominal trauma and was diagnosed as having retroperitoneal hematoma, a retroperitoneal bulky tumor was revealed at surgery. After that left orchiectomy was performed because the testicular swelling gradually developed. The retroperitoneal tumor was confirmed to be a secondary lesion metastasized from left testicular carcinoma.

Abdominal Injuries↗
PubMed1984

[A clinical case of secondary tumor of the penis from the rectum, with malignant priapism].

We report a clinical case of carcinoma of the rectum. A 45-year-old patient had undergone resection of the rectum and proctostomy 22 months ago. Carcinoma caused metastasis to the corpora cavernosa of the penis in this patient, and caused local recurrence of the carcinoma of the rectum, pulmonary metastasis and malignant priapism. A statistical analysis of 62 cases of secondary tumor of the penis in Japan was also made. The present clinical case was the 62nd case of secondary tumor of the penis in Japan, and the 4th case of secondary penile tumor from the rectum. The primary foci of the secondary tumor of the penis are mostly in the urinary bladder and the prostate, followed by the rectum, kidney, pelvis of the kidney and the ureter. Primary sites in the urogenital organs were found in 82.3% and in the neighboring organs in 85.2%. As the route of metastasis of the secondary tumor of the penis, arterial blood, retrovenous, retro-lymph and direct infiltrating metastasis may be possible. Secondary tumor of the penis is mostly found in aged persons, and the major symptoms may be penile nodule and mass, malignant priapism, penile pain and tenderness, and difficulty in urination and retention of urine. Regardless of the length to metastasis and difference in the treatment of the metastatic focus, the secondary tumor of the penis is poor in prognosis, and survival period may be up to 7 months. From the findings of post-mortem examination, secondary tumor of the penis should be regarded as a secondary sign due to recurrence of the primary tumor or presence of metastasis in other organs, and careless surgical operation should be avoided.

Adenocarcinoma↗
PubMed1984

[A case report of retroperitoneal Schwannoma].

A 37-year-old man with complaints of lassitude and slight lumbal pain, who had been found to have a low abdominal median mass and was referred to our hospital by a practitioner, was admitted for further examination. IVP, examination of the gastrointestinal tract by the oral procedure and re-examination of the colon by a double contrast procedure revealed deviation of the right ureter, the urinary bladder and the alimentary tract. This mass was found to be a retroperitoneal tumor with central necrosis by low abdominal CT scanning and the low abdominal echography. The mass was removed easily, though it was slightly adherent to the anterior surface of the sacral bone. Pelvic lymphadenectomy was also done simultaneously. The removed mass was encapsulated by fibrous tissue, round in shape, 750 grams in weight (13 by 12 by 12 cm), evenly flat, elastic soft and contained 230 ml bloody exudate at the center. Histologically this mass contained areas where oval and spindle cells made palisading arrangement and areas where the tumor cells had no communication with each other and stroma was edematous. However, hyperchromatism of nuclei of tumor cells and high cellularity indicated this mass to be a malignant Schwannoma. Dissected lymph nodes had no metastatic involvement. Since the surgical margin was detected to be invaded by tumor cells, postoperative prophylactic irradiation of Linac (10 Me V-X, total doses 4,750 rads) was performed on the whole pelvis. This patient has been well and has had no signs of recurrence of tumor for 23 months after the operation. Ninety-four cases of benign retroperitoneal Schwannoma and thirty-six cases of malignant retroperitoneal Schwannoma reported in Japan are reviewed.

Adult↗
PubMed1983

Use of magnetic emulsion as a novel drug carrier for chemotherapeutic agents.

Magnetic guidance of magnetic emulsion for site specific delivery was investigated in vitro and in vivo. The magnetic emulsion was characterized in vitro for its magnetic responsiveness using a constant flow apparatus, and its high retention by magnetic field was confirmed. After intravenous injection in rat, magnetic emulsions were localized to the predetermined site (lungs) by application of an electromagnet to the lungs. Similarly, 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea (methyl-CCNU) contained in the dispersed oily phase of the emulsions, was also concentrated at the target-site. Such preferential localization by magnetic means suggested that magnetic emulsions could become effective drug carriers with site specificity for the delivery of chemotherapeutic agents in cancer chemotherapy.

Animals↗