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Biomedical subjects

M Abe

Publications and source records attributed to M Abe.

At least 1,387 records · Page 77Linked to original sources
PubMed1983

[Biological and physical approach to the improvement of radiotherapy].

A double blind trial of misonidazole (MISO) was undertaken. A total of 147 patients were enrolled. They were randomly allocated into two groups receiving either MISO or placebo. They were irradiated with 2 Gy 5 times a week to a total dose of about 60 Gy. 0.5g/m2 of MISO was given orally 4 hours before each irradiation. The effect of the treatment was evaluated as a decrease in the volume of the tumors. No radiosensitizing effect of the drug was observed. Twenty-nine tumors considered to be radioresistant were treated by RF hyperthermia combined with radiation. 48% of the tumors developed complete regression. No definite relationship between heat sensitivity of the tumors and their histological types was observed.

Animals↗
PubMed1983

Case of primary orbital hemangiopericytoma.

A case of primary orbital hemangiopericytoma was reported. A 44-year-old woman was first seen at our clinic in June 1970, complaining of exophthalmos of the right eye. On examination, the right eye showed a 6-mm proptosis and an upward displacement. Cerebral angiography revealed a vascularized mass occupying the lower and mid orbit. The tumor was surgically removed and diagnosed histologically as hemangiopericytoma. After the initial surgery, recurrent tumors in the right orbit were resected twice, in June 1975 and December 1979. The purpose of this presentation is to discuss the clinicopathologic features of the tumor. In addition, it is emphasized that hemangiopericytomas originating from the orbit or brain may be histopathologically identical to angioblastic meningiomas.

Adult↗
PubMed1983

Spontaneous rhythmicity induced by glucose removal in the guinea-pig tracheal smooth muscle.

Guinea-pig tracheal smooth muscle was mechanically quiescent in the normal Krebs-Henseleit solution, but rhythmic contraction appeared after removal of glucose from the solution with or without carbachol and was accompanied by a gradual decrease in the resting tension. There was no significant difference in lag time required for appearance of the rhythmicity and % decrease of the tension between glucose removal in the absence and presence of carbachol. Induction of the rhythmicity was limited by hypoxia plus glucose removal, without and with carbachol. The rhythmic contraction produced by glucose removal was low in amplitude and disappeared within one hour, whereas, when a low dose of glucose (0.1-0.2 mM) was periodically applied after glucose removal, the rhythmic contraction was higher in amplitude and continued for over 5 hr. The rhythmicity elicited by glucose removal in combination with an adequate supply of glucose was abolished by addition of glucose (0.22-0.25 mM), ATP (1.8 mM), or pyruvate (0.9 mM), accompanied by restoration of the tension to a certain degree, but not by 3-O-methyl glucoside (11.5 mM). The results suggest that the rhythmicity may be masked in normal metabolic states but unmasked in metabolically deficient states in the guinea-pig tracheal smooth muscle.

3-O-Methylglucose↗
PubMed1983

Malignant tumor of the eyelid--clinical survey during 22-year period.

A total of 52 malignant tumors of the eyelid treated at Kyushu University Hospital during the 22-year period from 1960 through 1981 were analyzed. The peak incidence in this series was in patients 70-79 years of age. There were 26 each of men and women. Squamous cell carcinoma was the lesion most frequently seen, i.e. in 25 cases (48.1%). Basal cell carcinomas were detected in 17, sebaceous adenocarcinomas in 7 malignant melanomas in 2 and malignant lymphoma in 1. In 13 cases, there were squamous cell carcinomas in the upper eyelid, 10 with basal cell carcinomas in the lower eyelid, and all with sebaceous adenocarcinomas in the upper eyelid. Follow-up information was obtained on 42 of the 52 cases. Twenty-four out of these 42 patients were living and 18 had died. There were two recurrences of squamous cell carcinomas and two of basal cell carcinomas. In two, there was a metastasis to the lung and in one the regional lymph nodes were involved. Thus, squamous cell carcinoma was the most frequently encountered malignant tumor of the eyelid seen in this series. We wish to stress the importance of examining specimens histologically, to ensure a rapid diagnosis and pertinent treatment.

Adenocarcinoma↗
PubMed1983

Empty sella syndrome with visual field disturbance.

Three patients with empty sella syndrome with various visual field disturbances were reported. In one patient there was evidence of enlargement of Mariotte spots, and in the others, irregular visual field defects. These three patients were initially suspected to have intraocular tumors because of the balloonings of the sella and visual field disturbances. However, the diagnosis of empty sella was confirmed by metrizamide cisternography and metrizamide computed tomography(CT). The results indicate that the patient with enlargement of the sella on the plain skull X-ray and visual field disturbance should be examined by metrizamide cisternography and metrizamide CT scan to differentiate from the intrasellar tumor.

Aged↗