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Biomedical subjects

L Simon

Publications and source records attributed to L Simon.

At least 199 records · Page 11Linked to original sources
PubMed1984

[HLA-A, B, C, and DR typing in rheumatoid polyarthritis].

HLA-A, B, C typing were performed in 72 caucasians with rheumatoid arthritis. HLA-DR typing were accomplished in 40 patients among these 72 subjects. DR4 was clearly increased with a frequency of 55 p. 100 versus 18 p. 100 in controls. We did not find an association between DR4 and the presence of rheumatoid factor. Clinical and biological signs are similar in rheumatoid arthritis with and without DR4. Two other HLA antigens, B40 and Cw3, were increased and their frequency was twice as high in patients as compared with controls. A synthesis of six studies published in the world confirms the elevation of B40 in this disease and later on suggests the elevation of Cw3 which is often linked with B40. The association of rheumatoid arthritis with B40 and Cw3 can be explained by a linkage disequilibrium between DR4 and B40 on the one hand, between DR4 and Cw3 on the other hand.

Adult↗
PubMed1984

A comparative dynamic study of the effectiveness of gastric cytoprotection by vitamin A, De-Nol, sucralfate and ulcer healing by pirenzepine in patients with chronic gastric ulcer (a multiclinical and randomized study).

The gastric cytoprotective effects of vitamin A, De-Nol and sucralfate were compared with the effectiveness of pirenzepine in healing ulcer in patients with chronic gastric ulcer. A total of 100 patients was randomized into different groups: the patients were treated with antacids, vitamin A (3 X 50.000 IU), De-Nol liquid (4 X 5 ml), sucralfate (4 X 1 g) or pirenzepine (3 X 50 mg). The treatment was continued for 4 weeks. At the beginning, 2 and 4 weeks after starting treatment the patients were subjected to endoscopy and the size of the ulcer was measured planimetrically. The ulcer-healing effect of De-Nol liquid was significantly better than that of the antacids (p less than 0.01). Ulcer size was reduced significantly in all groups (p less than 0.01), however, at the end of the study the gastric ulcers were smallest in the De-Nol treated group (p less than 0.001). The dynamics of ulcer healing in the second week was most favourable in the patients receiving vitamin A (p less than 0.01). The present data point to the cytoprotective effects of De-Nol liquid, vitamin A and sucralfate and to their ability of healing chronic gastric ulcers.

Adolescent↗
PubMed1984

Alkaline reflux esophagitis in gastroresected patients. Objective detection with a simple isotope method.

The incidence and severity of alkaline reflux esophagitis occurring in 1129 gastroresected patients were evaluated. As far as the incidence of esophagitis are concerned, no significant difference was found after Billroth I or Billroth II type resection. Severe esophagitis developed in 62.6 per cent of patients with total gastrectomy, but never occurred when a long limb Roux-en-Y anastomosis was also performed. The majority of esophagitis was recognized within the first year after resection, so it might be supposed that not only operative procedure itself but the postoperative care period might be responsible for the development of esophagitis. It can be avoided and treated by Roux-en-Y anastomosis. Scintigraphy is a simple rapid method in the detection of gastroesophageal reflux, thus patients can be selected by it for further invasive investigation.

Duodenogastric Reflux↗
PubMed1984

[Somesthetic evoked potentials of the spinal cord and cervico-brachial neuralgia].

Thirty patients with active cervico-brachial neuralgia were investigated by detection of the sensory action potential of the nerve, the spinal somaesthetic evoked potential and the cerebral somaesthetic evoked potential. Stimulation is applied to the affected side and symmetrically to the healthy side, at the finger and at the wrist. The digital stimulation recruits a more specific root territory (2nd finger C6-C7, 5th finger C8-T1). These results were compared to those obtained in a population of 14 controls. In cases of active cervico-brachial neuralgia, the spinal somaesthetic evoked potential from digital stimulation (N16) was always abolished in the painful territory; it was also abolished on the pain free side in 75% of cases, while it was present in 96% of the controls. The spinal somaesthetic evoked potential from stimulation of the wrist was only abolished on the painful side in 29% of cases, but the mean amplitude of N13 was reduced. In contrast, the cerebral somaesthetic evoked potential and the sensory action potential of the nerve were only minimally altered. These changes regress after clinical cure. There is a correlation between the severity of the clinical course and the electrophysiological findings. Isolated abolition of the spinal somaesthetic evoked potential from digital stimulation is a constant feature of benign cervico-brachial neuralgia, while abolition of the spinal somaesthetic evoked potential by stimulation of the finger and of the wrist, bilaterally, corresponds to the most severe forms.

Adult↗
PubMed1984

Vaginal drainage of posthysterectomy abscess under direct ultrasonic guidance.

Continuous real-time ultrasound was used to assist drainage of two infected posthysterectomy vaginal cuff hematomas. This method enabled the gynecologist to determine the position either of his finger or of the instrument in the cavity at all times. This allowed him to see that any loculations within the infected hematoma were broken down, and a draining Foley catheter was placed in a good position. The position of the ultrasound transducer on the anterior abdominal wall did not compromise the surgical field in any way.

Abscess↗
PubMed1984

[Calcium antagonism by papaverine in isolated rat gastric fundus strips in a model system].

Examining isolated strips of gastric fundus tissue of rats the authors observed that papaverin up to 7.8 X 10(-8) to 6.25 X 10(-7) mol/l increased the intensity of convulsions induced by constant amounts of barium chloride (9.5 X 10(-4); with further increase of the concentration the intensity of convulsions gradually sank under the initial value. An increased proneness to cramping was also observed when the calcium content of the Tyrode solution was reduced. In this case the proneness to cramping was highest between 1 and 1.3 mmol/l calcium content. When the calcium content was 1 mmol/l, papaverin increased the proneness to cramping only to a smaller degree, in agreement with the effect measured when the calcium content of the organ bath was reduced below 1 mmol/l. In model experiments, calcium antagonized the potential difference-increasing effect of papaverin at the ether/NaCl (0.1 mol/l) phase boundary. From this the authors infer an interaction (complex formation) between papaverin and calcium at the phase boundary, which is independent of the biological medium. Their findings and the papaverin -calcium antagonism first observed by Benigni [2] can be interpreted in this way.

Animals↗
PubMed1983

[Fractures of the calcaneus during fluoride therapy of osteoporosis].

Two cases of calcaneum "stress" fractures are reported. The fracture, which was unilateral in the first case and bilateral in the second, occurred 15 and 18 months respectively after the initiation of fluoride treatment for osteoporosis. The simultaneous discovery of thyrotoxicosis in the second patient suggests that the role of hyperthyroidism in the occurrence of these fractures be discussed in addition to that of fluoride treatment.

Aged↗
PubMed1983

[The intercapital metatarsal space. Anatomical and pathological aspects].

The metatarsal intercapital space is located in the forefoot, between two metatarsal heads and above the transverse inter-metatarsal ligament. The 2nd space is the narrowest, the 1st is the widest and the 3rd is the most mobile. It contains a connective tissue bursa which facilitates the sliding of the metatarsal heads. The existence of this bursa was confirmed in two cases of rheumatoid arthritis (at operation). As the bursa hypertrophies, it gradually extends beyond its normal site towards the dorsal or plantar region of the foot. The metatarsal intercapital space, like the metatarso-phalangeal joint, warrants thorough clinical investigation.

Arthritis, Rheumatoid↗
PubMed1983

Cytoprotective effect of vitamin A and its clinical importance in the treatment of patients with chronic gastric ulcer.

The effects of vitamin A were studied on the basal and maximal gastric secretory responses of 12 patients; and on healing in 60 patients with chronic gastric ulcer. The effect of vitamin A on ulcer healing was evaluated by a multiclinical, multicentre, randomized, prospective study in which the patients were divided into three groups. In group A the patients were treated with antacids only; in group B the patients were given antacids plus vitamin A (in doses of 3 X 50.000 U orally); and in group C the patients received antacids, vitamin A plus cyproheptadine (in doses of 3 X 4 mg orally). The treatment lasted four weeks. At the beginning and the end of treatment endoscopies were performed and ulcer sizes were measured planimetrically. Various other parameters such as ulcer index, antacid consumption and laboratory parameters were also evaluated during the four-week treatment. It was observed that: (i) vitamin A (given in doses of 100.000 U i.m.) decreased neither basal nor maximal gastric secretory responses; (ii) the number of patients with completely healed gastric ulcer was significantly higher (P less than 0.05) in groups B and C than in group A; (iii) the extent of ulcer reduction was significantly higher (P less than 0.01) in groups B and C than in group A; (iv) no significant changes were observed in ulcer index and antacid consumption during the four-week treatment in the different groups of patients; (v) the reduction of ulcer size was significantly greater (P less than 0.01) in the group treated with antacids plus vitamin A than in the group treated with antacids only, at two weeks of treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

Antacids↗
PubMed1983

Ultrastructural and crystallographic study of calcifications from a patient with CREST syndrome.

An ultrastructural and crystallographic study was done on calcium deposits obtained from a patient with the CREST syndrome. Optical microscopy showed that large calcific cutaneous deposits seemed to have developed in a dense connective tissue without any inflammatory reaction. The oldest lesions contained heterotopic bone. Electron microscopy showed that calcium deposit, in the slightly mineralized fibers, was located at the center of the elastic fibers. The calcifications were surgically removed and studies were performed on the rough products and, after heating, using x-ray crystallography, differential thermal analysis and quantitative chemical analysis. Our results showed that this cutaneous calcification is a B type carbonated apatite.

Aged↗
PubMed1982

[Singh femoral index in vertebral osteoporosis].

In 48 patients with osteoporosis and at least one vertebral fracture, the Singh vertebral index, which assesses the femoral trabeculation, was compared to the Meunier vertebral radiologic index, which is determined according to the number and severity of vertebral deformations. The femoral index was abnormal in all patients. However, the threshold level, set by Singh at Stage IV, which supposedly discriminates between subjects with and without osteoporosis could not be confirmed as one-third of the patients with at least one vertebral fracture were Stage V. A statistically significant correlation was found between the femoral index and the vertebral radiological index.

Aged↗