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Biomedical subjects

L Simon

Publications and source records attributed to L Simon.

At least 181 records · Page 10Linked to original sources
PubMed1987

[Teaching the patients with rheumatoid polyarthritis more about their disease].

A meeting in a hospital environment gathers, during 4 full days, five patients with rheumatoid polyarthritis, of similar evolutive stage, strictly selected after a complete work-up and determination of a medical and surgical treatment. The meeting around the rheumatologist and the nurse, of the physical therapist, ergotherapist, orthesist, chiropodist, psychologist, and the social worker, permits to explain to the patients, already informed about his/her disease, rules of hygiene, savings, training and rehabilitation which will be useful. The experience of 30 patients is presented and proposed as a desirable model, which is the only way to improve the patient's formation, since the physician does not have enough time to devote to this formation.

Arthritis, Rheumatoid↗
PubMed1986

Sequential multi-agent chemotherapy and whole abdominal irradiation for stage III ovarian carcinoma.

Modern therapy for stage III ovarian carcinoma patients usually involves one or more laparotomies with maximal resection of tumor, and intensive multi-agent chemotherapy. However, with long-term follow-up only 10-15% of patients remain free of disease. In the hope of improving outcome, we have treated 17 women with sequential multimodality therapy, including initial surgical resection (if possible), cyclophosphamide-adriamycin +/- cis-platinum, second-look surgery, and whole abdominal irradiation. Seven patients are currently alive without disease, with median follow-up of 52 months since initiation of radiation and 60 months since initiation of chemotherapy. Disease-free survival correlated with residual tumor at the start of radiotherapy: none (4/4); microscopic, less than or equal to 5 mm (3/4); greater than 5 mm or no surgery (0/9). Survival also correlated with tumor grade: grade 1 (2/2); grade 2 (2/3); grade 3 (3/11). Hematological tolerance of radiotherapy was dependent upon the number of chemotherapy cycles: ten of 11 patients receiving less than or equal to eight cycles completed radiotherapy without excessive delay, compared with only one of five receiving greater than eight cycles. There were no treatment-related deaths and only one patient required laparotomy for bowel obstruction. We conclude that intensive multimodal treatment may be tolerated moderately well if the amount of chemotherapy is limited, and that further studies are justified.

Adult↗
PubMed1985

Recrystallization from ether causes unusual changes in the convulsant activity of pentylenetetrazol.

The convulsant activity of commercial pentylenetetrazol (PTZ) and that of pentylenetetrazol recrystallized from ether (PTZE) were compared in the waking rabbit by means of recording the electrical activity of the brain. In addition, the interaction between the two substances was studied. When given in slow intravenous infusion, PTZE proved only half as effective as PTZ (threshold doses: 23.18 +/- 1.8 mg/kg and 12.40 +/- 0.7 mg/kg, respectively). One single infusion of PTZE 5-10 days prior to the administration of PTZ decreased the latter's convulsant activity to half of the original, while PTZ pretreatment left the activity of PTZE unaltered. Previous physico-chemical investigations suggested that, after recrystallization from ether the molecule might be present in dimer form at the phase-boundaries. Such a process, if taking place also at the cell membrane surface might account for the diminished convulsant activity of the recrystallized molecule.

Animals↗
PubMed1985

[Gigantocystic form of kidney cancer].

The rarely appearing gigantocystic form of the carcinoma of the kidney diagnosed in a 57-year-old male is described. In connection with the case the possibilities of the development of the cysts which were observed in cystic carcinoma of the kidney as well as the clinical, diagnostic, therapeutic and prognostic problems of this form of tumour are discussed.

Carcinoma, Renal Cell↗
PubMed1985

Some aspects of the critical evaluation of peptic ulcer therapy in patients.

The disease peptic ulcer in patients does not present a uniform clinical entity. Hence, the therapeutic approaches to peptic ulcers are significantly different. Independently from the therapeutically given drugs, some common problems can be found in the methods of critical evaluation of the peptic ulcer therapy in patients. This paper deals with goals, the possible ways to evaluate critically the efficacy of peptic ulcer therapy and the problems in patients in relation to both evaluation of clinical pharmacology and as well as to everyday medical practice.

Anti-Ulcer Agents↗
PubMed1984

Association of parvoviruses with rheumatoid arthritis of humans.

A small virus resembling parvoviruses in its morphological and physicochemical properties was derived from synovial tissue of a patient with severe rheumatoid arthritis. This virus, designated RA-1, elicits a syndrome in neonatal mice that includes neurological disturbances, permanent crippling of limbs, dwarfism, alopecia, blepharitis, "masking," and a rigid curvature of the thoracic spine. Polyclonal antibodies against RA-1 display high virus neutralizing activity and in immunoassays detect reactive antigen in synovial cells from different rheumatoid arthritis patients but not persons with osteoarthritis. Putative parvoviruses isolated from several other rheumatoid arthritis patients are only weakly pathogenic for newborn mice but can generate RA-1 virus-specific antigens in tissues of these animals. It has not been established that RA-1 and existing parvoviruses of mammalian species are related.

Animals↗
PubMed1984

[Febrile reaction to D-penicillamine].

Two personal observations of febrile reaction to D-penicillamine in patients with rheumatoid arthritis provide the opportunity for recalling the clinical presentation which is fairly uniform. The physiopathological mechanism is still unknown. In Wilson disease, progressive reintroduction of the drug may be successful.

Adult↗