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Biomedical subjects

L Juhlin

Publications and source records attributed to L Juhlin.

At least 145 records · Page 8Linked to original sources
PubMed1980

A lidocaine-prilocaine cream for superficial skin surgery and painful lesions.

A eutectic mixture of lidocaine and prilocaine in a water emulsion cream base produces effective superficial dermal analgesia when applied under occlusive dressing for 60 minutes. On the genitals, lips and oral mucosa, the application time can be reduced. The cream was found to be an effective alternative to conventional infiltration anesthesia for dermabrasion and superficial surgical procedures. It is especially useful in children for the removal of molluscum contagiosum and prior to venepuncture. The preparation is also an effective pain reliever when used on certain ulcerations.

Administration, Topical↗
PubMed1980

Endotoxin-induced microclots in ulcerative colitis and Crohn's disease.

Radially oriented fibrin microclots were observed when blood from patients with active lesions of Crohn's disease and ulcerative colitis was kept in capillary tubes for 24 h. Addition of bacterial extract or endotoxins increased the fibrin formation. The phenomenon is not seen in healthy subjects or patients who have healed after colectomy. The data are consistent with our findings in patients with vasculitis and support the view that patients with Crohn's disease and ulcerative colitis have circulatory endotoxins.

Adolescent↗
PubMed1980

[Pharyngeal gonococcal infections].

Pharyngeal gonococcal infection is a not uncommon manifestation of gonorrhea. Its prevalence depends on the type of population selected for evaluation and varies between 0 and 16%. Diagnosis requires at least two specimens, one from the throat and one from the tonsillar crypts and the performance of the fermentation test. Transmission of N. gonorrhoeae to the throat is common by fellatio, uncommon by other kinds of contact. Results of auxotyping are non-uniform. for treatment penicillin

Anti-Bacterial Agents↗
PubMed1979

The epidermal helix: a model for the bilayer couple phenomenon.

Narrow strips of isolated epidermis rapidly assume a helical conformation when placed in a dilute hypotonic aqueous solution of histamine as a free base. The same belical formations could be induced by dilute hypotonic solutions of alkalis or acids. This coiling resulted from damage to the malpighian cells, with consequent asymmetric osmotic swelling of the epidermis, thus producing torsional forces on the stratum corneum. In essence, the epidermal helix proved to be a pH dependent, osmotically induced, bilayer couple phenomenon.

Animals↗
PubMed1979

Diagnostic sign of hyperglycemia: persistent movement of neutrophil granules.

This study describes a functional marker in the blood of diabetics: the motility of neutrophil granules in vitro. When heparinized blood from patients with diabetes mellitus was kept in capillary tubes for 24 hours, a rapid and intense movement of the granules in the neutrophil leucocytes was regularly seen. In blood from normoglycemic diabetics and normal subjects, no granular motion was seen at 24 hours, but in these cases prolonged motion could be induced by the prior addition of glucose.

Adult↗
PubMed1979

The effect of corticosteroids on in vitro endotoxin-induced microclots.

The in vitro endotoxin-induced fibrin microclots could be completely inhibited in blood by treating the patient with an oral dose of 30--60 mg prednisone 24 h before drawing the blood sample. When added to 100 ml blood in vitro, the minimal inhibiting dose of corticosteroid is 0.004 mg betamethasone or 0.5 mg hydrocortisone.

Betamethasone↗
PubMed1979

Inhibition of hyperhidrosis by topical application of a local anesthetic composition.

An eutectic mixture of 5% lidocaine and 5% prilocaine applied locally to the skin inhibited epinephrine-induced sweating in healthy subjects. It also inhibited palmar and axillary hyperhidrosis from 1 to 6 hours after application to 15 of 17 patients tested. A placebo lotion was without effect. When used daily for 3--4 weeks, only 25% of the patients were very pleased with the treatment. The reason for the decrease of efficacy is uncertain.

Administration, Topical↗
PubMed1978

[Methods for the detection of drug allergies].

The following in vitro methods are predominantly discussed: Specific IgE determination (RAST). The test can be used to detect allergies of the immediate type such as anaphylactic shock and urticaria. Antibodies can be detected to a limited number of drugs such as penicillin, ACTH, TSH, insulin, asparaginase and proteins of animal sources. Degranulation of basophil leucocytes and histaminliberation have been used for many years. The practical value of the test has been limited but improved methods for analysis have given the tests hopes for a come-back. Cellular tests like lymphocyteproliferation and macrophage inhibition test (MIF) do not yet give such information which make them helpful as practical tests to detect drug allergy.

Basophils↗
PubMed1978

Ultraviolet light inhibition of oriented fibrin formation in psoriasis.

Radially-oriented fibrin crystallization was induced by incubation of blood from psoriatic patients with killed Pseudomonas aeruginosa. The phenomenon was inhibited by irradiation of the buffy coat in plasma with UV-B. It was not inhibited by UV-A unless trioxsalen had been added. Addition of UV-A-irradiated plasma to non-irradiated buffy coat also inhibits the fibrin formation.

Crystallization↗
PubMed1978

Skin reactivity and phagocytic function of neutrophil leucocytes in Crohn's disease and ulcerative colitis.

A decreased capacity of the leucocytes to phagocyte yeast particles was found in patients with Crohn's disease of the ileum. Patients with lesions only in the colon showed normal phagocytic activity as did patients with ulcerative colitis (U.C.). Intradermal injection of killed Strep. pyogenes produced an increased erythrmatous reaction after 48 hours in patients with U.C., and the reaction was pustular in half of them. None of the controls or the patients with Crohn's disease of the ileum had such a reaction. An increased erythematous reaction to streptokinase-streptodornase was also more common in patients with U.C. than in those with Crohn's disease and a control group. No such difference was seen to other bacterial antigens. The reactivity to kallikrein, prostaglandin E1, histamine or bradykinin did not differ from that of normal subjects.

Adolescent↗