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Biomedical subjects

L Bodin

Publications and source records attributed to L Bodin.

At least 91 records · Page 5Linked to original sources
PubMed1990

Number of mature follicles ovulating after a challenge of human chorionic gonadotropin in different breeds of sheep at different physiological stages.

The ovulatory response of ewes from breeds that differ widely in prolificacy (Ile-de-France, ++ Booroola Merino, Romanov, F+ Booroola Merino and F+ Booroola Romanov with adult ovulation rates of about 1.5, 1.2, 3, 3 and 3.5 respectively) to 750 IU of hCG given at different physiological stages (before puberty, during anestrus or during the luteal phase) was compared. In all except one experiment, hCG induced ovulation in 73 to 98% of the lambs, indicating that follicles sensitive to LH were present at all stages studied. Ranking of the breeds according to hCG-induced ovulation rate in prepuberal lambs was similar to that based on adult ovulation rate. Furthermore, hCG induced more ovulations in prepuberal F+ than in ++ lambs (3.7 +/- 1.4 vs 1.7 +/- .8 at 4.5 mo of age) as well as in anestrous ewes (F + at 3.1 +/- 1.8 vs ++ at 1.6 +/- .7). Within ewes, the correlation between hCG-induced ovulation rate and mature ovulation rate was positive in nonprolific breeds but not significant in prolific breeds. We conclude that 1) the number of hCG-induced ovulations can be used to identify sheep that are carriers of the Booroola gene and 2) the mechanisms responsible for a number of large ovulatory follicles typical of a breed are present at stages (prepuberal, anestrus, luteal phase) other than the follicular phase.

Animals↗
PubMed1990

Rapid aetiological diagnosis of pneumonia based on routine laboratory features.

The values of some basic laboratory features on admission to hospital were recorded and compared in 418 adult patients with community-acquired pneumonia, namely erythrocyte sedimentation rate, C-reactive protein, white blood cell (WBC) count, serum lactate dehydrogenase (S-LD), serum alanine-aminotransferase, and serum sodium. Discriminant analysis was performed to obtain an aetiological diagnosis. WBC value of greater than 15 x 10(9)/l strongly indicated a bacterial and, especially a pneumococcal aetiology, whereas increased S-LD could imply a mycoplasmal infection. For patients less than 50 years of age the equation C2 = -1.788 + 0.204 x WBC-0.0909 X S-LD was constructed, in which C2 greater than 0 indicated a pneumococcal aetiology. This function correctly classified 31/33 (93.9%) patients with a mycoplasmal and 20/31 (64.5%) patients with a pneumococcal infection. Patients with viral, Haemophilus influenzae or chlamydial infection could not be discriminated from each other. The age of the patient, WBC and possibly S-LD on admission are easily accessible parameters and these results could therefore be of value in daily clinical practice in hospitals.

Adolescent↗
PubMed1990

[Sinusitis during intensive care. Prospective studies].

Two series of ICU patients, the first one with nasal endotracheal intubation, the other one with a tracheostomy, were included in a prospective and comparative study with repeated CT scans of the sinuses. Radiological sinus involvement is seen in both groups almost constantly; purulent sinusitis are often seen in both series. Unexplained fever should make us look for a sinusitis, even in patients with early tracheostomy. Moreover, our results ask for more study about associated causes, apart from nasal endotracheal intubation.

Critical Care↗
PubMed1989

[Comparative evaluation of 2 fiber optic catheters for the continuous measurement of Svo2].

Nineteen intensive care patients with shock and acute respiratory failure were studied using two different fiber-optic catheters used for the continuous measurement of mixed venous blood oxygen saturation (SVO2). In groupe I patients (n = 11), a Swan-Ganz catheter with optic fibres emitting light characterized by three different wavelengths was used (Opticath Oximetrix). In groupe II patients (n = 8), a Sat-one Edwards catheter was used instead (only two different wavelengths). All the patients were studied in the early stages of shock, once all the calibration procedures had been carried out. An increase in FIO2, using PEEP, fluid replacement therapy and vasoactive drugs or diuretics all improved the cardio-respiratory status of each patient. After each new therapeutic procedure, SVO2 was measured in blood samples obtained from these catheters, and from the pulmonary artery (to give the reference value, using an OSM3 Hemoximeter). Over a period of 1.5 to 6 h, 119 measurements were carried out in Group I, and 91 in Group II. The correlation coefficient was higher with the Oximetrix catheter than with the Edwards one (r = 0.970 and 0.855 respectively; p less than 0.001). Moreover, the 24 h spontaneous drift of the former catheter was less than that of the latter (+3.3 +/- 3.1% vs. +9.3 +/- 7%, p less than 0.05). This study showed that a catheter with optic fibres emitting a light with three wavelengths is more accurate than one emitting only two for the measurement of changes in SVO2 in critically ill patients.

Adult↗
PubMed1989

[Factors influencing mixed venous oxygen saturation in intensive care].

Changes in mixed venous blood oxygen saturation (SvO2) were studied in 2 groups of patients. Group I patients (n = 10) were all hypoxaemic, suffering from acute respiratory failure, requiring that FIO2 be maintained at 1 throughout the study; respiratory and haemodynamic conditions were improved using PEEP and cardiovascular support. On the other hand, Group II patients (n = 13) were non-hypoxaemic patients with circulatory shock in whom FIO2 was gradually increased, and the haemodynamic status was improved using positive inotropic drugs (dopamine, dobutamine, adrenaline, amrinone). All 23 patients had a Swan-Ganz catheter set up for monitoring; all the usual haemodynamic and respiratory parameters were measured. Haematocrit values were kept at the same level throughout the study. Haemodynamic parameters were measured each time a new therapeutic procedure was carried out. No close relationship between SvO2 changes and changes in cardiac index or O2 consumption were found. However, a close relationship existed between changes in SvO2 and changes in O2 extraction (EAO2): SvO2 = -EAO2 + 102 (Group I; r = 0.90, n = 54); SvO2 = -1.2 EAO2 + 103 (Group II; r = 0.93, n = 66). A strong relationship was also found between changes in SvO2 and in FIO2 in each patient of Group II. In the complicated physiological set-up of an intensive care patient, SvO2 reflects oxygen extraction. A fall in SvO2 is related to an altered oxygen demand: oxygen supply ratio. In the most seriously ill patients, there is no relationship between changes in SvO2 and cardiac index.

Adult↗
PubMed1989

Pregnancy outcome among working women.

The influence of occupational factors on the outcome of pregnancy was investigated in a prospective study of 3901 women who worked during their pregnancy and received prenatal care in Orebro County from October 1980 to June 1983. Data on occupational factors, social circumstances, and life-style factors were obtained from questionnaires. There were no significant differences in the incidence of adverse pregnancy outcome (spontaneous abortion, perinatal death, birth defects, or low birthweight) between the nine occupational categories used when nonoccupational factors were accounted for. No increased risk was found for exposure to organic solvents, but the adjusted risk ratio of adverse outcome was 1.28 (95% CI 0.91-1.80) for "other chemical exposures." The work conditions in this county have been generally favorable in recent years, and the results therefore cannot be generalized to conditions with higher exposures. Methodological problems such as misclassification of exposure and the possible bias resulting from different rates of legal abortions among occupational groups are discussed.

Abortion, Spontaneous↗
PubMed1988

Retinal detachment. A study of a population-based patient material in Sweden 1971-1981. IV. Prediction of surgical outcome.

The association between the outcome of 531 surgically treated retinal detachments (RD) and preoperative findings was studied by logistic univariate and multivariate analysis. The following factors were significantly, and negatively associated with the surgical results: 1) previous RD in the same eye, 2) pre-operative visual acuity less than 2/60, 3) cloudy ocular media and/or a poorly dilated pupil, 4) an RD area of more than three quadrants, and 5) no retinal breaks detected. In the multivariate analysis no significant association was found for 9 factors: open angle glaucoma, interval of more than 2 months between symptoms and surgery, aphakia, pre-operative hypotony, absence of demarcation lines, posterior retinal breaks, pre-operative proliferative vitreo-retinopathy, sex and age. The significant factors combined with aphakia were studied in all conceivable combinations. The estimated probability of failure varied between 4 and 93%, indicating that the most important factors were observed.

Female↗
PubMed1988

Myocardial contusion in patients with blunt chest trauma as evaluated by thallium 201 myocardial scintigraphy.

Fifty five patients suffering from blunt chest trauma were studied to assess the diagnosis of myocardial contusion using thallium 201 myocardial scintigraphy. Thirty-eight patients had consistent scintigraphic defects and were considered to have a myocardial contusion. All patients with scintigraphic defects had paroxysmal arrhythmias and/or ECG abnormalities. Of 38 patients, 32 had localized ST-T segment abnormalities; 29, ST-T segment abnormalities suggesting involvement of the same cardiac area as scintigraphic defects; 21, echocardiographic abnormalities. Sixteen patients had segmental hypokinesia involving the same cardiac area as the scintigraphic defects. Fifteen patients had clinical signs suggestive of myocardial contusion and scintigraphic defects. Almost 70 percent of patients with blunt chest trauma had scintigraphic defects related to areas of myocardial contusion. When thallium 201 myocardial scintigraphy directly showed myocardial lesion, two-dimensional echocardiography and standard ECG detected related functional consequences of cardiac trauma.

Adult↗
PubMed1987

Antibiotic therapy in pneumonia: a comparative study of parenteral and oral administration of penicillin.

An open, randomized study of treatment of radiologically verified community-acquired pneumonia is described. 33 patients were treated with phenoxymethylpenicillin orally in an average dose of 2 g every 8 h, and 36 patients were treated intravenously with benzylpenicillin 3 g every 8 h. When temperature was normalized the antibiotic dose was reduced in both groups to oral phenoxymethylpenicillin in an average dose of 1 g every 8 h. 24 and 26 patients in respective groups completed 10 days of therapy. No statistically significant differences between the two groups were found when compared for duration of fever, hospital stay, CRP, ESR, leukocyte counts and X-ray normalization. In spite of the low number of patients included in this study it gives a clear indication that treatment of pneumonia with penicillin by the oral route results in the same outcome as parenteral treatment when patients suffering from vomiting, diarrhoea and severe illness with respiratory distress are excluded. In addition, oral treatment is cheaper than parenteral and more simple to manage.

Administration, Oral↗
PubMed1986

Frequency of extrasystoles in healthy male employees.

To determine reference values for ectopic activity 147 actively employed healthy men aged from 15 to 65 years were examined by 24 hour Holter monitoring during their ordinary daily activities. Age was the only risk factor significantly associated with supraventricular and ventricular extrasystoles. During a six year follow up only two men died. In both the frequency of ventricular extrasystoles had been high, but neither of them died from cardiovascular disease. Because the distribution of the frequency of extrasystoles in the study group was highly skewed a percentile distribution was used to determine normal values. This distribution showed that 95% of men aged 15-39 years had less than 2.9 ventricular extrasystoles per hour and the same proportion of men aged 40 years or older had less than 36 ventricular extrasystoles per hour. For field studies values above the 90th percentile (that is more than 10 ventricular extrasystoles per hour for men 40 years or older) may be a more appropriate cut off point.

Adolescent↗
PubMed1986

[Post-stress nonlithiasic acute cholecystitis. Contribution of ultrasonics to the diagnosis and treatment in 50 cases].

Fifty cases of post-stress acute acalculous cholecystitis were observed during the past 9 years, mainly after major surgery or trauma. The apparently increasing incidence over the last 4 years (42 cases) could probably be explained by a better diagnostic approach of this condition by routine use of ultrasonography. No specific etiological factor could be found; however total parenteral nutrition and/or sepsis and/or use of narcotics could possibly play a role in the appearance of this complication. Although diagnosis can occasionally be suspected in the basis of abdominal and infectious signs, diagnosis was made primarily on the following ultrasonographic signs: enlarged gallbladder with thickened wall, sludge, and occasionally a double-wall aspect and a pericholecystic collection. In this series, most of the patients were treated by cholecystectomy, but a new therapeutic approach was used in 10 cases: percutaneous transhepatic drainage under sonographic control. Outcome is still poor, with a 50 p. 100 mortality rate.

Acute Disease↗
PubMed1985

Ventilatory decrements in former asbestos cement workers: a four year follow up.

A four year follow up of the ventilatory function in former asbestos cement workers has been performed to determine whether any further decrease occurred after cessation of exposure. Seventy five of 125 subjects were eligible for re-examination and were compared with local referents. None showed signs of asbestosis but 32% had pleural plaques at the renewed examination. Cumulative asbestos exposure calculated as fibre x years had been estimated individually in the original examination. After adjustment for age, height, tracheal area, and smoking category the FVC and FEV1 for all exposed subjects were on average 7% v 6% less than predicted from the referents and twice as much for the subjects with the highest exposure. The four year declines in FVC and FEV1 were larger than in the referents, significantly so for FEV1. There were no significant correlations between pleural plaque and ventilatory function after adjustment for exposure. Thus the age adjusted reduction in ventilatory function had progressed during the follow up period despite the cessation of exposure and the lack of radiological signs of asbestosis.

Adult↗
PubMed1984

Decreased lung function in long-term asbestos cement workers: a cross-sectional study.

The effect on lung function of exposure in an asbestos cement plant was investigated in male workers, employed more than 10 years. The exposed group was selected to exclude subjects with pneumoconioses and ex-smokers and consisted of 77 smokers and 48 never-smokers. Referents were chosen from plants where asbestos had not been in use and restricted to those without X-ray signs of chest disease. The primary type of asbestos used was chrysotile and the general dust level in the two decades 1950-1970 seems to have been around 10 mg/m3 while the asbestos fiber concentration averaged 2 fibers/ml. The mean differences between exposed and referents were statistically significant for forced vital capacity and forced expiratory volume, -0.25 and -0.30 liters, respectively, after adjustment for age, height, tracheal area, and smoking category. No significant differences were detected between those with and without pleural plaques. Smokers and never-smokers were similarly affected. In conclusion, the group exposed to dust with comparatively low asbestos fiber concentration had a minor impairment of lung function, mainly due to obstructive changes.

Air Pollutants, Occupational↗
PubMed1983

Neuropsychological test results and symptoms among workers with well-defined long-term exposure to lead.

Lead intoxication is a classical environmental hazard that can cause encephalopathy. During recent years several studies have suggested poor performances in psychological tests and increased numbers of subjective symptoms among workers with comparatively low blood lead concentrations. Forty-nine long-term lead-exposed male workers with time-weighted average blood lead concentrations between 1.3 and 3.3 mumol/l calculated from at least seven years' results have been compared with a referent group of 27 male industrial workers with normal blood lead concentrations and comparable intellectual backgrounds. Several indices of exposure were used. Both groups were examined with neuropsychological tests and a questionnaire covering neuropsychiatric symptoms. The exposed group performed less well in 11 of 14 non-verbal tests, and there were significant differences in tests of memory and reaction time. A non-linear dose-effect trend was indicated. The results are in accordance with those found in similar studies, and it is concluded that the blood lead concentration should be below 2.5 mumol/l to avoid the effects shown in this study.

Adult↗
PubMed1981

Relation between concentrations of metronidazole and Bacteroides spp in faeces of patients with Crohn's disease and healthy individuals.

Nine patients wih Crohn's disease and six healthy individuals were given 400 mg metronidazole twice daily and the concentration was measured in plasma and faeces 6 to 8 h after intake. Quantitative and qualitative bacteriological examinations were performed before and during treatment. The concentrations of metronidazole in plasma varied between 5 and 30 mg/l as measured by liquid chromatography (LC) and between 3 and 20 mg/l as measured by a bioassay (BA) method. There was no significant differences between the results of the two methods in patients but compared with BA the LC values were regularly lower in the healthy subjects. Metronidazole was detected in the faeces of most patients. These findings coincided with a significant reduction of Bacteroides spp in their faeces which was not apparent in healthy individuals in whom metronidazole was not detected in the faeces. Higher faecal metronidazole concentrations were found in patients with active disease and a total colon involvement as compared with the patients with a more quiescent disease and involvement of ileum and ascending colon only.

Adolescent↗