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Biomedical subjects

L Beck

Publications and source records attributed to L Beck.

At least 163 records · Page 9Linked to original sources
PubMed1982

Antigenic variation in cancer metastasis: immune escape versus immune control.

Antigenic variation in cancer metastasis was observed in a syngeneic murine tumor system consisting of a low metastatic parental tumor line (derived from a methylcholanthrene-induced DBA/2 T lymphoma, Eb), a high metastatic spontaneous variant thereof (ESb), and a low metastatic 'revertant' from ESb (ESb-M). All three lines expressed tumor-associated transplantation antigens (TATA) which elicited specific T cell-mediated antitumor immune reactions in the host. The strongest host response was elicited upon intradermal inoculation. It could be followed by (a) the infiltration of the locally growing tumor by host cells, such as lymphocytes and macrophages, (b) the establishment of specific systemic antitumor immunity, (c) the generation of immune cells capable of transferring protective antitumor immunity into a normal syngeneic recipient, and (d) the generation of tumor specific cytotoxic T lymphocytes (CTL). Anti-TATA CTL were used as typing reagents to investigate the stability or variability in the TATA expression by cloned tumor cell lines. Antigenic variability in the TATA expression was seen under various conditions: (a) clone-dependent variation in the sensitivity to anti-TATA CTL lysis upon prolonged growth in tissue culture, (b) qualitative change in the TATA (TATA1 leads to TATA2) upon successive i.p. transplantation of the parental Eb tumor line and, (c) generation of TATA negative immune escape variants (TATA2 leads to TATA-) during metastasis formation from a s.c. site. The relative inefficiency of specific immunization procedures against ESb was found to be due to the effective generation of TATA negative variants by this highly metastatic tumor. The balance between immune control and immune escape could be influenced to the advantage of the host by some means, for instance optimizing the route of antitumor-immune sensitization or by infusion of allogeneic but H-2 identical antitumor-immune T cells. Such immune cells recognized the tumor via minor histocompatibility antigens and thus circumvented the need of TATA recognition. Finally, manipulations at the cell surface of the highly malignant ESb tumor such as those introduced in the ESb-M variant were found to dramatically effect its metastatic potential.

Animals↗
PubMed1981

Effect of chronic propranolol treatment and withdrawal on norepinephrine and tyrosine hydroxylase in sympathetic tissues.

Abrupt discontinuation of propranolol in patients with coronary artery disease may lead to untoward ischemic events. The explanation for this clinical syndrome has been thought to be related to a physiological sympathetic rebound. To investigate a biochemical basis for this hypothesis we administered propranolol (5 mg/kg s.c.) twice daily to guinea-pigs for 2 weeks. Heart rates gradually declined during treatment and after cessation of the drug returned to control level without evidence of rebound. Left ventricular and right atrial norepinephrine levels were unchanged in the withdrawal period. Tyrosine hydroxylase activity was unchanged in the right atrium but had declined significantly in the left ventricle at 96 hr. Tyrosine hydroxylase activity was unchanged in the stellate ganglion and adrenal gland. Thus, we did not find any alterations in catecholamine metabolism compatible with a sympathetic rebound state.

Adrenal Glands↗
PubMed1980

[Twin pregnancy, one fetus with Down syndrome removed by sectio parva, the other delivered mature and healthy (author's transl)].

We report about a twin pregnancy with trisomy 21 in one of the fetus and normal caryotype of the other one. The affected fetus was removed by sectio parva in the 22nd week of gestation (p. m.) while the placenta remained inside the uterus. At the end of the 38th week of gestation a mature healthy baby was delivered by caesarean section. This was only possible by knowing the exact position of the fetus, placentas and amnion cavities by ultrasound. It is necessary to be familiar with betamimetics for tocolysis used during and after surgery.

Abortion, Legal↗
PubMed1980

[Maternal complications following conduction anaesthesia during a delivery (author's transl)].

The danger of maternal complications during local and conduction anaesthesia during delivery is important for the indication for the choice of the method and for informed consent from the patient prior to delivery. Data on maternal complications since 1960 in the use of the pudendal block, the paracervical block, spinal anaesthesia for vaginal deliveries and Caesarean sections, single shot lumbar epidural anaesthesia and continous catheter lumbar epidural anaesthesias and caudal anaesthesias are presented. The respective anaesthetic risk apparent from this data are discussed.

Anesthesia, Caudal↗
PubMed1979

The exstrophy support team: a new concept in the care of the exstrophy patient.

The concept of the exstrophy support team is reported. It has extended the care of children with exstrophy into a lifelong continuum of effective assistence, not just by way of medical and surgical interaction but through knowledgeable and sympathetic coordination. There has been a spectacular improvement in over-all lifetime survival and much greater patient interest and appreciation with better followup and maintenance so that we can help quickly and effectively when problems arise. Now that we have achieved an increased longevity for these patients, we must be able to assure them the best possible quality of life.

Bladder Exstrophy↗
PubMed1979

Group psychotherapy on a children's urology service.

This paper describes an ongoing program, in a large metropolitan hospital, of weekly group meetings for hospitalized children on the Babies Hospital Urology Service, led by a pediatric psychiatrist and a psychiatric social worker. The purpose of the program is to help children cope with the multitude of fears and anxieties that can arise in the course of hospitalization. Although not described in detail, corollary weekly group meetings are also held with parents of the children. The authors describe the format of their meetings with child patient groups, whose composition is, by its nature, a constantly changing one. Examples are excerpted from typical group sessions, indicating the kinds of problems that surfaced and how they were dealt with. Ways in which group interaction and support contributed to the positive results of such meetings are also shown. The authors suggest that their program can be utilized in a variety of hospital settings.

Adolescent↗