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Biomedical subjects

L B Nelson

Publications and source records attributed to L B Nelson.

At least 73 records · Page 4Linked to original sources

High hyperopia in Leber's congenital amaurosis.

Few studies comment on the type of refractive errors found in patients with Leber's congenital amaurosis. The association of an uncomplicated infantile form of this condition with high hyperopia but without systemic complications has been suggested. In a retrospective study, we identified 11 patients who satisfied the criteria for the diagnosis of this subtype of Leber's congenital amaurosis. All of our cases were found to have at least +6.00 diopters of hyperopia on cycloplegic refraction. No systemic abnormalities were found in any of these children. We suggest that high hyperopia be included in the diagnostic criteria of this specific form of Leber's congenital amaurosis.

Blindness↗

Progression of congenital anterior polar cataracts in childhood.

We studied five patients with the unusual and insidious progression of congenital anterior polar cataracts during childhood. All five children ultimately required surgery. In two children the progressive opacification occurred in posterior portions of the lens and was inapparent to parents. We therefore recommend a regular and careful follow-up of all children with anterior polar cataracts.

Adult↗

Silsoft extended wear contact lenses in pediatric aphakia.

Fifty pediatric aphakic patients, ranging in age from 7 days to 11 years, were fitted with the Silsoft extended wear contact lens. Compared to other extended wear lenses, the Silsoft lens has several advantages. These include easier handling, a less traumatic fitting procedure for the child, the use of fluorescein for evaluation of the lens-cornea relationship and a low loss rate. This lens appears to be safe, with no permanent adverse effects on the cornea.

Aphakia, Postcataract↗

Primary glaucoma associated with iridotrabecular dysgenesis and ectropion uveae.

We present nine patients with unilateral congenital ectropion uveae (hyperplasia of the iris pigment border), iris hypoplasia, characteristic gonioscopic findings, and glaucoma. A majority of these patients also demonstrated mild ptosis. In none of these patients were there any associated systemic abnormalities. The apparent ectropion uveae results from spread of the iris pigment epithelium beyond the iris ruff and onto the anterior surface of the iris. In two patients with this abnormality, histopathologic and electron microscopic findings are presented. All patients with congenital ectropion uveae should be carefully examined periodically to detect glaucoma.

Adolescent↗

Large bimedial rectus recessions in congenital esotropia.

The success rate of large (6 and 7 mm) bimedial rectus recessions in 45 congenital esotropes with deviations of 50 prism dioptres or greater was found to be 91%. Judgment of final alignment was made six weeks postoperatively, with an average follow-up of 13 months. Large bimedial rectus recessions are an effective surgical treatment for congenital esotropia. This procedure does not significantly alter adduction, and leaves other muscles available should further surgery be necessary. These findings show that initial surgery on three or more muscles is unnecessary in congenital esotropia.

Adolescent↗

Nanophthalmos associated with cryptorchidism.

Nanophthalmos is a rare, isolated ocular disorder characterized by a small eye and cornea, shallow anterior chamber, narrow angles, and a high lens/eye volume ratio. A 39-year-old patient with nanophthalmos developed glaucoma. He was noted to have a tall, thin body, feminine features, and testicular atrophy.

Adult↗

Aphakic correction in ectopia lentis.

Ectopia lentis may cause a reduction in visual acuity, which varies with the type and degree of dislocation and the presence of other ocular abnormalities. Retinoscopy may reveal a significant refractive error, usually myopia and astigmatism. Occasionally, an accurate refraction may be difficult because of tilting or dislocation of the lens. If aphakic refraction improves visual acuity, an aphakic correction should be considered.

Aphakia↗

The slipped rectus muscle.

A slipped rectus muscle may occur as a result of ophthalmic surgery or ocular trauma. We reviewed seven cases of slipped rectus muscles following retinal detachment surgery, strabismus surgery, or trauma. Diagnosis, etiology, treatment, and prevention are discussed.

Adolescent↗

Painful bullous keratopathy following pediatric cataract surgery with intraocular lens implantation.

A child with a history of a monocular congenital cataract, cataract surgery and intraocular lens implantation at age three developed pseudophakic bullous keratopathy which persisted following intraocular lens removal and vitrectomy two years later. At age nine she presented to the Cornea Service at Wills Eye Hospital with painful bullous keratopathy and underwent a penetrating keratoplasty and anterior vitrectomy. The case is presented to bring attention to potential long-term corneal complications of pediatric cataract surgery with intraocular lens implantation.

Cataract Extraction↗

Medical management of congenital nasolacrimal duct obstruction.

A consecutive series of 113 infants seen with congenital nasolacrimal duct obstruction were treated with local massage and topical antibiotic ointment. In 107 of the infants the obstruction was resolved within 8 months of initiation of this form of management. Nearly all of the infants were spared a surgical procedure that probably would have been performed if early probing of the nasolacrimal system had been advocated.

Combined Modality Therapy↗

Acute acquired comitant esotropia.

Acute acquired comitant esotropia is characterized by a dramatic onset of a relatively large angle of esotropia with diplopia and minimal refractive error. Two children, aged 41/2 and 61/2, who suddenly developed a nonaccommodative comitant esotropia are presented. There was no preceding trauma or febrile illness, and neurologic evaluation (including CT scans and Tensilon testing) was normal. Bimedial recession provided satisfactory alignment.

Acute Disease↗

Retrobulbar anesthesia in strabismus surgery.

Forty-nine patients, ranging in age from 12 to 77 years, underwent strabismus surgery under local anesthesia. With standard preoperative medication and a retrobulbar injection of 2% mepivacaine hydrochloride (hyaluronidase added in 12 patients), effective anesthesia was obtained. Twenty-four patients were observed during the immediate postoperative period, and return of extraocular muscle function and visual acuity was found to be complete an average of 3.8 hours after the injection. The addition of hyaluronidase significantly altered the duration of the anesthetic. Local anesthesia may be a preferable technique in terms of decreased morbidity, especially in the older patient. The short duration of anesthesia and lack of side effects also enable the surgeon to use adjustable sutures and make the final adjustment relatively early in the postoperative period.

Adjuvants, Anesthesia↗

Treatment of congenital ptosis with frontalis suspension: a comparison of suspensory materials.

One hundred forty-five consecutive frontalis suspension procedures performed during the years 1976 to 1982 at the Wills Eye Hospital for the repair of congenital ptosis were reviewed. Results with nylon polyfilament cable-type suture ( Supramid Extra) as the suspensory material were compared to results with allogenic fascia lata. Forty-nine of the 121 polyfilament cable-type suture procedures (40.5%) were considered failures either because of ptosis recurrence (28.1%) or granuloma formation (12.4%). Only two of 24 (8.3%) of the fascia lata cases failed. No granuloma was associated with the use of fascia lata. The clinical and pathologic characteristics of ptosis recurrence and suture-rejection granuloma formation are discussed. Available preparations of allogenic fascia lata are reviewed and suggested as alternatives to the use of nylon polyfilament cable-type sutures for the repair of congenital ptosis.

Blepharoptosis↗

Surgical management for abnormal head position in nystagmus: the augmented modified Kestenbaum procedure.

Patients with nystagmus and an eccentric null point in lateral gaze may assume an abnormal head position to maximise visual acuity. Surgical procedures for this condition can result in significant undercorrection of the head turn. A follow-up of 15 patients for an average of 33 months revealed a sustained improvement in head position with the use of the augmented modified Kestenbaum procedure.

Adolescent↗