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Biomedical subjects

K Ueda

Publications and source records attributed to K Ueda.

At least 1,333 records · Page 74Linked to original sources
PubMed1985

[Combination effects of CDDP, ACR and HCFU on progressive urothelial tumors].

Nine patients with progressive urothelial tumors treated with combination chemotherapy were evaluated. The median age of the patients was fifty-four; 6 men and 3 women; 7 of the tumors were of the renal pelvis and/or ureter and at stage C or D at the time of initial chemotherapy. Another of the tumors was triple cancer (bladder, prostate, sigmoid) and the remaining case was of bladder cancer. The stage of the two bladders cancers was T4. All patients were treated with CDDP (cis-platinum), ACR (aclarubicin hydrochloride) and HCFU (carmoful) and given from one to 3 courses repeated at three-week intervals (mean 2.3 courses). Seven patients were evaluable while two had no evaluable lesions. The response with this chemotherapy was 2 cases of PR (28.5%), 4 cases of NC and one case of PD. No severe toxicities such as nephrotoxicity or cardiotoxicity, were revealed with this combination chemotherapy.

Aclarubicin↗
PubMed1985

[Clinical investigation of ceftizoxime sodium suppositories in the field of pediatrics].

The clinical study of CZX-S in the field of pediatrics was performed and the following results were obtained. The overall effect of CZX-S was "markedly improved" in 2 and "moderately improved" in 4 of the 6 patients with bacterial infection. Bacteriological findings show that causative organisms were eradicated in all the 5 patients observed. The breakdown of the organisms was S. aureus, S. pyogenes, S. pneumoniae, H. influenzae and E. coli. The serum concentration of CZX was 3.3 approximately 15.4 micrograms/ml (mean +/- S.E. 8.9 +/- 2.0 micrograms/ml) at 15-37 minutes after initial rectal administration with CZX-S 125 (dose: 7.7-11.9 mg/kg). While, in the CZX-S 250 administratered group, the serum concentration was 3.1 micrograms/ml and 10.5 micrograms/ml at 20 minutes after initial rectal administration (dose: 5.6 mg/kg and 14.7 mg/kg). The urinary recovery rate up to 6 hours after initial rectal administration was 68.6% in 1 patient given CZX-S 125 and 28.3-52.5% (mean +/- S.E. 38.7 +/- 7.2%) in 3 patients given CZX-S 250. Side effects and abnormalities in laboratory test values were not observed in any cases.

Adolescent↗
PubMed1985

[Clinical study of recombinant interferon alpha-2 (Sch 30500) in advanced gynecological cancers].

Recombinant interferon alpha-2 (Sch 30500) was administered to 29 patients with advanced gynecological cancers (14 patients with cancer of the cervix, 8 with ovarian cancer, 4 with uterine sarcoma, 2 with endometrial cancer and 1 with unclassified cancer). No antitumor effects (CR and PR) were noted in 23 evaluable patients. Side effects observed were fever, tachycardia, diarrhea, chills, general fatigue, anorexia, nausea and vomiting. In some patients, leukopenia, decrease of hemoglobin and elevation of SGOT and SGPT were observed. No production of antibody for Sch 30500 was noted.

Adult↗
PubMed1985

[Clinical studies on cefminox in pediatric field].

Clinical studies on cefminox (CMNX, MT-141) were conducted and the following results were obtained. Twelve cases of bacterial infections were treated with CMNX with a satisfactory result of "excellent" in 9 and "good" in 3. Antibacterial activity was examined in 7 cases. Pathogenic organisms which were S. aureus, beta-Streptococcus, H. influenzae, S. pneumoniae and P. morganii were eradicated in all the cases. Mean maximum serum concentrations of CMNX after intravenous injection of 10, 20 and 40 mg/kg were 54.5 mcg/ml, 102.3 mcg/ml and 202.4 mcg/ml, respectively which were obtained 15 minutes after each injection. Mean half-lives of each dose group were 1.60, 1.13 and 1.51 hours, respectively. Mean urinary excretion rates of CMNX at 6 hours after intravenous injection in 10, 20, 30 and 40 mg/kg groups were 73.5%, 80.9%, 92.6% and 66.5%, respectively. Side effects were not observed clinically, but anemia in 1 case and eosinophilia in 2 cases were noted in laboratory examination.

Adolescent↗
PubMed1985

Histologic pattern of early heart allograft rejection under cyclosporine treatment.

The histologic abnormalities associated with early heart rejection in cyclosporine-treated patients are not fully characterized. To study these abnormalities, Lewis rats received ACI heart-lung allografts and two weeks of cyclosporine treatment. Then the therapy was discontinued. Controls were sacrificed at that time; other animals were sacrificed three, six, and nine days later. The rejection score was determined solely by the percentage of necrotic myocardium, while 13 other histologic parameters were semi-quantitatively graded to identify parameters of early rejection of the heart. There was no evidence of myocardial necrosis or significant inflammation three days after discontinuation of therapy. At six and nine days, despite the absence of myocyte necrosis, there were significant increases in the grades for interstitial and endocardial inflammation, venous cuffing, perivascular inflammation with intermyocyte extension and arterial vasculitis. Our quantitative and semi-quantitative histologic analysis identified abnormalities of the early stage of heart rejection that may provide clues in defining rejection prior to the development of myocyte necrosis.

Animals↗
PubMed1985

[Susceptibility of bacteria isolated from lower respiratory tract infections to antibiotics (1983)].

Bacterial isolates from the patients with pulmonary infections have been collected over these 3 years, in collaboration with investigators at 13 hospitals in various parts of Japan for the study on frequency of isolation of pathogens among the patients and their drug susceptibilities. Possible causative pathogens mainly isolated from sputum in patients with lower respiratory tract infections during period from September 1983 to March 1984, were collected. The frequency of bacterial isolates from the sputum and their drug susceptibility on H. influenzae among the various pathogens are discussed. The kinds of bacterial species isolated from the patients with respiratory tract infections associated with chronic bronchitis, chronic capillary bronchitis or bronchiectasis and their relative frequency of isolation were as follows; Total numbers of bacterial isolates collected from various hospitals were 220 strains in 1981, 168 strains 1982 and 258 strains in 1983. H. influenzae was always isolated with highest frequency of 50.5% in 1981, 45.8% in 1982 and 40.7% in 1983, and followed by P. aeruginosa (24.1%), S. aureus (8.2%), S. pneumoniae (7.3%) and K. pneumoniae (5.9%) and E. coli (4.1%) in 1981; P. aeruginosa (30.4%), S. pneumoniae (11.9%), S. aureus (4.8%), K. pneumoniae (3.0%) and E. coli (1.8%) in 1982; P. aeruginosa (26.7%), S. pneumoniae (10.1%), S. aureus (7.8%), K. pneumoniae (3.5%) and E. coli (3.5%) in 1983. The drug susceptibility test of H. influenzae to ampicillin (ABPC), piperacillin (PIPC), mezlocillin (MZPC), sulbenicillin (SBPC), gentamicin (GM), amikacin (AMK), cefotiam (CTM), cefmetazole (CMZ), cefoperazone (CPZ), cefotaxime (CTX), ceftizoxime (CZX), cefmenoxime (CMX) and latamoxef (LMOX) was done by using agar micro-broth dilution methods. H. influenzae was most markedly susceptible to cephems of the third generation, especially to CMX, CZX and CTX by which about 95% of H. influenzae tested were inhibited the growth under the concentration with less than or equal to 0.10 microgram/ml of the drugs. Furthermore, annual changes in susceptibility of H. influenzae to various antibiotics was analyzed over the period from 1981 to 1983. The frequency of S. pneumoniae isolated from patients with chronic bronchitis or bronchiectasis was about 10% in this survey. However, in the case of respiratory infections associated with bacterial pneumonia, the frequencies were as follows; 24.8% (77 cases/311 cases) in 1981, 17.7% (44 cases/248 cases) in 1982, and 11.0% (39 cases/355 cases) in 1983. The frequency of isolation of S. pneumoniae decreased every year.(ABSTRACT TRUNCATED AT 400 WORDS)

Adult↗
PubMed1985

[A study on administration of antibiotics during operation for prevention of postoperative infections].

Two antibiotics, piperacillin (PIPC) and cefoperazone (CPZ) were administered during operation and determined of efficacy for prevention of postoperative infections. Following administration of PIPC and CPZ during operation, high serum concentrations were obtained. In exudates not so high concentrations were achieved with either PIPC or CPZ. This was considered to be probably due to the period and methods of collection of specimens used in this study. Bacteriological studies of washings of wounds obtained during operation gave negative results in all cases. It was considered that administration of antibiotics during operation may suffice for prevention of postoperative infections for all cases with relatively short operation time excepting for cases operated for malignant tumors or urinary tract lithiasis.

Adult↗
PubMed1985

[Cytogenetic, morphological and clinical studies on partial hydatidiform moles].

To establish the clinical management of partial moles, cytogenetic, morphological and clinical studies of 57 partial moles, including three twin cases, were performed. The karyotypes of the 54 singletons were 46 triploid and eight diploid. By examining the genetic markers, two of the diploid moles were proved to be derived from normally fertilized conceptuses. Molar tissues from two twin cases had a 46,XX karyotype of androgenetic origin, while the normal placenta and fetus were derived from normal conceptuses. An embryo (or fetus) (26.9%) or only an umbilical cord (9.6%) was found in some triploid and diploid moles. Vessels with erythroblasts were also recognized in most cases. In addition, there was a positive correlation between cyst formation and gestational length in triploid conceptuses. These findings suggest that triploid partial moles are an altered form of missed abortion. The mole became invasive in one twin case with an androgenetic mole, but the remaining cases had uneventful courses. These results indicate that partial moles can be divided into three groups: Triploid, Diploid derived from normally fertilized conceptus, Binovular twins with androgenetic mole, and that, except for those in group 3, partial moles have no malignant potential and require no intensive follow-up.

Chorionic Gonadotropin↗