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Biomedical subjects

K Taniguchi

Publications and source records attributed to K Taniguchi.

At least 901 records · Page 50Linked to original sources
PubMed1982

[Phase II study on peplomycin for esophageal cancer].

For the purpose of verifying the effectiveness of peplomycin, one of the derivatives of bleomycin, against carcinoma of the esophagus and the safety of it, the analysis of the data for total 113 cases collected from 25 institutions in Japan was made. The results are as follows. It was effective in 19 out of 74 evaluable cases of carcinoma of the esophagus (25.7%). In case of treatment with peplomycin alone, it was effective in 6 out of 39 cases (15.4%). In case of the combination treatment with peplomycin and some other therapy, it was effective in 13 out of 35 cases (37.1%). As for the side effects, the incidence of fever was the highest in both the cases of peplomycin alone and the combination treatment such as 39.6% and 37.0%, respectively. Anorexia, nausea, vomiting, respiratory symptoms and tiredness were found in relatively many cases. In the clinical laboratory tests, the vital capacity after the treatment tended to be lower than that before the treatment, but there was little change in the hematological tests, pulmonary function test and renal function test.

Adult↗
PubMed1982

Accessory cell function in tumor-bearing mice and effects of Corynebacterium parvum.

Primary in vivo production of antibody to sheep red blood cells (SRBC) was consistently suppressed in EL 4 tumor-bearing C57BL/6 mice, but the secondary response was not suppressed. This suppressed primary in vivo production of antibody was partially restored by systemic administration of Corynebacterium parvum. For investigation of the mechanism of the immunosuppression in tumor-bearing mice and the effects of C. parvum, the accessory cell function of adherent cells from tumor-bearing mice and C. parvum-treated tumor-bearing mice in in vitro cultures was studied. Peritoneal and splenic cells from tumor-bearing mice were less efficient in promoting in vitro production of antibody to SRBC by macrophage-depleted normal nonadherent cells than the adherent cells from normal mice. C. parvum treatment restored the accessory cell function of splenic adherent cells from tumor-bearing mice but not that of peritoneal cells. Furthermore, adherent cells from tumor-bearing mice did not show suppressive activity against the in vitro plaque-forming cell response.

Animals↗
PubMed1982

[Contrast echocardiographic evaluation of right ventricular filling profiles in patients with right ventricular volume or pressure overload].

UNLABELLED: Contrast echocardiographic examinations were performed to evaluate hemodynamic filling profiles in patients with right ventricular overload as well as in normal adults. The subjects were 15 cases of atrial septal defect (ASD) as a representative of right ventricular volume overload, 13 cases of mitral stenosis (MS) as a condition with right ventricular pressure overload and 15 cases of normal adults. M-mode contrast echocardiograms were recorded through the ultrasonic beam direction determined by two-dimensional echocardiograms as shown in Fig. 1. RESULTS: 1) In diastole, continuous rapid linear flow through the tricuspid valve orifice was observed in 11 patients with ASD, while biphasic rapid linear flow was noted in normal adults (control) and in patient with MS. 2) Maximum flow velocity (MFV) in early diastole and flow velocity in atrial contraction phase (AFV) were larger in cases with ASD than that of the control subjects. However, there was no difference in rapid filling time (RFT) between patients with ASD and MS. 3) The characteristic findings of tricuspid valve echoes in cases of ASD included increased valve opening velocity (TOV), decreased diastolic descent rate (TDDR), and high F point. These findings were correlated well with increased MFV and prolonged RFT. 4) MFV was decreased secondarily to the increment of pulmonary artery pressure. 5) Turbulent flow in the right-sided chamber was observed in patients with pulmonary hypertension. These results suggest that linear contrast echoes in the M-mode echocardiograms may be useful for the evaluation of flow velocity and flow profiles across the tricuspid valve orifice in patients with right ventricular volume or pressure overload.

Adult↗
PubMed1981

Highly selective inhibitors of thromboxane synthetase. 1. Imidazole derivatives.

The structure--activity relationships of imidazole derivatives as inhibitors of thromboxane (TX) synthetase were investigated. Introduction of various substituents (e.g., one or two methyl groups, a halogen atom, a methylidene group, unsaturated bonds, or a phenylene group) into the alpha position or other positions in the carboxy-bearing side chain of 1-(7-carboxyheptyl)imidazole (15) was found to increase the inhibitory potency. The length of the side chains with the phenylene group was optimum for the inhibitory potency on TX synthetase in the region of 8.5-9.0 A. Among the tested imidazole derivatives, 1-(7-carboxy-7-methyl-2-octynyl)imidazole (47), 4-[3-(1-imidazolyl)-propyl]benzoic acid (50), and (E)-4-(1-imidazolylmethyl)cinnamic acid (54) and its alpha-methyl analogue (57) showed the highest potency with an IC50 in the range of 10(-8) to 10(-9) M. Inhibition by these derivatives was highly selective for the TX synthetase, since other enzymes such as fatty acid cyclo-oxygenase and prostacyclin synthetase were not affected.

Animals↗
PubMed1981

Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives.

The enzyme thromboxane (TX) synthetase is inhibited by pyridine. The beta-substituted pyridine derivatives showed higher inhibitory potency than the gamma-substituted ones having the same side chain. Among the beta-substituted derivatives containing the omega-carboxyalkyl group, the compounds with 6-8 carbon atoms in the side chain were especially effective. The derivatives holding the phenylene group in the side chain exhibited much higher inhibitory activity than those of the alkylene type. Among them, (E)-3-[4-(3-pyridylmethyl)phenyl]-2-methylacrylic acid hydrochloride (5a) had the highest potency (IC50 = 3 x 10(-9) M). The beta-substituted pyridine derivatives and 1-substituted imidazole derivatives which had the same side chain showed almost the same potency. The beta-substituted pyridine derivatives do not inhibit arachidonic acid cyclooxygenase or prostaglandin I2 synthetase, two other enzymes of the arachidonic cascade.

Animals↗
PubMed1981

Partial purification and properties of urinary thiol proteinase inhibitors.

The urinary thiol proteinase inhibitors u-TPI1 and u-TPI2 were partially purified from human urine by gel filtration on Sephadex G-50 and Sephadex G-100 columns, and affinity chromatography on a trypsin.chymotrypsin-Chromagel A-2 column. They showed similar inhibition spectra to that of plasma inhibitors, inhibiting ficin strongly and papain moderately, but not inhibiting trypsin and chymotrypsin. The molecular weights of u-TPI1 and u-TPI2 were determined to be 76,000 and 22,500 by gel filtration on Sephadex G-150 and G-75, respectively, and their isoelectric points were found to be 4.6 and 4.8 by isoelectrofocusing. u-TPI1 and u-TPI2 were labile at acidic pH, but stable at neutral and alkaline pH. Both inhibitors were relatively thermostable, showing no decrease in activity on heating up to 50 degrees C for 1 h. The antibody against plasma thiol proteinase inhibitor alpha1-TPI suppressed the activities of the urinary inhibitors significantly, and on double immunodiffusion formed clear precipitin lines with both u-TPI1 and u-TPI2. On immunoelectrophoresis u-TPI1 migrated in the alpha 2-region and u-TPI2 in the beta 1-region. It is concluded from these data that the urinary thiol proteinase inhibitors are degradation products of the plasma inhibitors.

Chromatography, Affinity↗
PubMed1981

Further studies of 35--40 nm virus-like particles associated with outbreaks of acute gastroenteritis.

Virus-like particles similar in size and morphology to the Otofuke agent, which was detected first in an institutional outbreak of acute gastroenteritis at Otofuke, Hokkaido, Japan in 1978, were again observed in faeces from patients in four other outbreaks of acute gastroenteritis in Hokkaido. In each of three outbreaks in which the faeces and paired sera of patients were available, apparent sero-responses against the particles obtained in corresponding outbreaks were confirmed. Serological analysis of the particles from five separate epidemics by immune electronmicroscopy suggested that the particles from these epidemics may be related antigenically to one another. Besides the above-mentioned particles measuring 35--40 nm in diameter, 15--20-nm "empty" particles were also found in the stool specimens obtained from two of the five epidemics. In addition, serological cross reactivity between these two kinds of particles was observed. These findings provide further support for the aetiological role of the 35--40-nm particles (Otofuke agent-like particles) in acute gastroenteritis in older children and adults.

Acute Disease↗