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Biomedical subjects

K Tamura

Publications and source records attributed to K Tamura.

At least 1,207 records · Page 67Linked to original sources
PubMed1985

Identification of complex phenotype (OKT4+/OKT8+) on adult T-cell leukemia cells by sequential application of indirect rosette assay with protein A-coated ox red blood cells and immunoperoxidase technic.

The specific immunophenotypic characterization of the hematologic malignant diseases has been obtained most commonly by the immunofluorescent technic. It requires a microscope with illuminator or the expensive flow cytometer that usually precludes morphologic assessment. It was compared with the indirect rosette assay and the immunoperoxidase study, which allowed both immunologic and morphologic assessment. These three technics appeared to be comparable quantitatively, and the latter two technics utilizing cytospin preparations were applied sequentially to the leukemic cells of adult T-cell leukemia with a complex phenotype (OKT4+/OKT8+) and successfully displayed the double markers on each leukemic cell.

Animals↗
PubMed1985

Cystic dysplastic kidneys associated with Dandy-Walker malformation and congenital hepatic fibrosis. Report of two cases.

The combined abnormalities of Dandy-Walker malformation, congenital hepatic fibrosis, and generalized cystic dysplastic kidneys were found in two sanguineously unrelated premature babies. This type of cerebrohepatorenal malformation is certainly unique and is generally diagnosed based on the characteristic renal lesion. Remarkably, similar renal lesions have been found in Meckel's syndrome, Goldston's syndrome, and Miranda's syndrome. The present cases can be distinguished from Meckel's syndrome on the basis of the presence of Dandy-Walker malformation and the absence of polydactyly and occipital meningoencephalocele. Although the authors' cases resemble the latter two syndromes in terms of the presence of Dandy-Walker malformation, it is tentatively considered that the distinct triads found in the present cases could represent a new variant of a multiple malformation syndrome with generalized cystic dysplastic kidneys. The etiology of these cases remains unclear, but a genetic factor, which has been suggested as for other syndromes, might be involved.

Abnormalities, Multiple↗
PubMed1985

[Functional architecture of smooth muscle sphincters: longitudinal and circular muscles, encircling the anal canal in cats and dogs].

The short-lasting 'burst' activity was recorded from decerebrate, unanesthetized cats and dogs, by means of a single, bipolar needle electrode, originally aimed at recording of 'slow spikes' of internal anal sphincters. The recording of the 'burst' was more accessible in cats than in dogs, although the same macro-electrode, of which diameter was 0.3 mm, has been used throughout. There was no such species difference of accessibility for recording of 'slow spikes' of internal sphincters. Histological examinations indicated that the difference of accessibility may be due to relative thinness of muscular tissue in the cat. Some of the bursts were seen simultaneously on the background of continuous 'slow spikes', however, the most of the bursts appeared in reciprocal manner with those 'slow spikes', namely, the bursts were elicited by rectal distension, while the 'slow spikes' of internal sphincters were wholly inhibited by the same distension. The participation of bursts to the anal canal pressure was little in fact, though the longitudinal length of anal canal was invariably shortened, whenever the repetitive bursts occurred either spontaneously or in response. It is concluded that the 'burst' activity is generated by longitudinal muscles of anal sphincters. The observation suggests further that cell-to-cell electrical communication does not operate between longitudinal and circular muscles in this portion, instead, that neural mechanism regulates dominantly for co-ordination of those muscles encircling the anal canal.

Anal Canal↗
PubMed1985

Unusual complications of central venous catheterization in thrombocytopenic patient.

An unusual complication from subclavian venous catheterization is reported. A 63 year old white female with thrombocytopenia following chemotherapy for erythroleukemia developed mediastinal haematoma after inserting a left subclavian central catheter. Subsequent bilateral pleural effusion and right sided pneumothorax supervened and led to respiratory distress requiring multiple therapeutic thoracenteses.

Catheterization↗
PubMed1985

Ascites with peritoneal myeloid metaplasia in a patient with advanced non-Hodgkin's lymphoma.

Peritoneal myeloid metaplasia associated with ascites containing numerous hemopoietic cells in a patient with non-Hodgkin's lymphoma is described. It is suggested that massive infiltration of lymphoma cells into the bone marrow caused marrow failure and compensatory mechanisms supervened leading to myeloid metaplastic implants in the peritoneum associated with ascites as well as in the liver, spleen and lymph nodes. There was also a significant leuko-erythroblastic reaction in the peripheral blood.

Ascites↗
PubMed1985

Malignant lymphoma in the Miyazaki district: analysis of 237 biopsy cases.

Pretreatment biopsy specimens of 237 consecutive patients with malignant lymphoma, who presented to us from 1979 to 1982, were reviewed and reclassified. According to the new classification proposed by the Lymphoma Study Group of Japan (LSG), there were 226 patients with non-Hodgkin's lymphoma (NHL) which was further classified as diffuse lymphoma (216 cases), follicular lymphoma (4 cases), mycosis fungoides (4 cases), and others (2 cases). The 216 cases of diffuse NHL were subdivided into small cell (2 cases), medium-sized cell (71 cases), mixed (7 cases), large cell (92 cases), pleomorphic (40 cases), lymphoblastic (3 cases), and Burkitt's type (1 case) lymphoma. Cell surface marker studies using conventional methods were performed on 65 NHL patients, of whom 45 showed T-cell marker and 11 B-cell marker, and 8 had neither marker. The average survival periods were 13.1 mo for 107 patients with NHL, 27.9 mo for those with mycosis fungoides and 70.0 mo for 10 patients with Hodgkin's disease. Patients with adult T-cell leukemia survived for an average of only 5.5 mo. Histologically diffuse pleomorphic type had the worst prognosis. T-cell lymphoma appeared to have a poorer prognosis than B-cell lymphoma.

Adolescent↗
PubMed1985

[Healing of operative cardiac wounds].

Healing process of operative cardiac wounds was studied histopathologically in 14 patients who died 28 hours to 5 years after the operation of cardiac valve replacement. Repair of wounds in aorta and free wall of atrium was characterized by production of neointima and proliferation of collagen fiber at adventitia of aorta or epicardium of heart. Adhesion with granulation tissue at left ventricular venting wounds was observed in the case of 18th post-operative day. Reticulofibrosis of surrounding intracardiac muscle played an important role in development of granulation tissue. Cicatrix with collagen fiber was appeared from one month after the operation. In spite of attenuation of ventricular scar, aneurysmal bulging could not be observed. The basic healing pattern of wound in atrial septum was production and thickening of neointima. Granulation tissue rarely developed at the septum. Adhesion between sutured edges of atrial septal endocardium could not be observed and the dead space there remained over a period of 7 months after the operation. These findings indicated the continuous presence of unexpected weakness of the sutured septum until sufficient thickening of neointima had developed.

Adult↗
PubMed1985

Serum concentration of sisomicin by intravenous infusion and its clinical response as a single agent.

SISO in doses of 1.0 to 1.8 mg/kg was administered by a 30-minute intravenous infusion every 12 hours to 10 patients with infections, 9 of whom had underlying diseases including malignant diseases, diabetes mellitus, and diabetes insipidus with indwelling FOLEY catheter. The serum concentration of SISO was around 6.75 micrograms/ml in the end of infusion, and less than 1.0 micrograms/ml at 8 to 12 hours after infusion. SISO was given to the patients as a single agent for at least 3 to 5 days and all patients experienced an excellent to good response clinically, and causative organisms which showed a minimal inhibitory concentration of less than 1.56 micrograms/ml disappeared after the treatment associated with clinical improvement. There were no untoward effects noted in this study.

Adult↗