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Biomedical subjects

K Stern

Publications and source records attributed to K Stern.

At least 37 records · Page 2Linked to original sources
PubMed1983

Percutaneous absorption of clindamycin in the pig and the rat.

Clindamycin HCl in a 3% formulation was applied twice daily to the back skin of three white (Yorkshire) and three black (Hampshire) pigs for 22 days. Partial thickness samples of skin were obtained by use of a dermatome on shaved opposite sides at 4 hours and 5 days posttreatment. More than twice the antibiotic activity (P less than or equal to .001) was found in thinner (254 micrometers epidermis) samples than in thicker (1016 micrometers epidermis and dermis, 1 to 3) samples. A significantly higher content of antibiotic (P = 0.015) was retained in the skin of black pigs at five days posttreatment. Groups of ten Upjohn Sprague-Dawley rats were treated similarly with clindamycin phosphate in a 3% formulation three times daily for 22 days. At termination of treatment antibiotic activity was widely distributed, whereas at five days posttreatment residual activity was confined largely to samples of treated skin. No cutaneous irritation due to treatment was observed in either study.

Animals↗
PubMed1982

Autogenous dermal grafting vestibuloplasty in dogs.

Vestibuloplasties were done in dogs, using autogenous dermis as a graft material. Clinical and histologic examination was done at 10, 17, 21, and 28 days. Results showed good graft take and a final appearance resembling that of mucosa. Histologic findings correlated well with clinical appearance. From this investigation it appears that the dermis acts as a true graft and not just as a biologic dressing.

Animals↗
PubMed1978

Eikenella osteomyelitis of the mandible associated with anemia of chronic disease.

An unusual case of mixed bacterial osteomyelitis has been reported. The prodominant organism, E corrodens, normally is an inhabitant of the aerodigestive tract; its pathogenicity should not be overlooked in the diagnosis and treatment of oral infections. In addition, descriptions of anemia of chronic disease and of the spontaneous healing of a large defect of the bone have been presented.

Adult↗
PubMed1978

Defective chemotaxis in uremia.

Of uremic patients, 37% demonstrated the presence of CFI in their sera. The serum factor acts directly on leukotatic factors, C5f, C3f, and BF to render them irreversibly inactive. Inhibitory activity was found in five of 16 patients: 37% to 61% for C5f, 25% to 36% for C3f, and 28% to 51% for BF. There is no correlation of this inhibitory activity with BUN or creatinine levels. The presence of this chemotactic inhibitor may be responsible for the increased incidence of infection in uremia.

Aminocaproic Acid↗
PubMed1977

Vestibular extension with xenogenous fascial grafts.

Fascia obtained from the abdominal wall of a rat was transplanted to the oral cavity of five dogs as a graft material for vestibular extension. In all five dogs the grafted fascia remained in place as the surgical defects were covered with epithelium, which transpired within a period of 4 weeks. After 6 months, the vestibular depth was increased significantly and the vestibule was smooth and regular.

Animals↗
PubMed1976

Intraoral-mucosal-xenogenous fascial grafting.

Fascia obtained from the abdominal wall of a rat was transplanted into mucosal defects created in six dogs. In all of the dogs, the fascia was found to adhere firmly to the underlying tissue and surrounding epithelium. Biopsy specimens were taken at weekly intervals for 4 weeks. The defects healed without any apparent contracture and were covered by new epithelium. It appears that xenogenous fascia is a potentially useful graft material for intraoral soft tissues.

Animals↗
PubMed1975

Suppression of immune responses to sheep red cell antigens in rats preimmunized with heterophilic antigen: cellular events.

Depression of humoral immune response to sheep red cells (SRC) has been observed in rats previously immunized with heterophilic (Forssman) antigen. Analogous phenomena were observed by assay of splenic plaque-forming cells obtained from rats immunized in vivo with heterophilic antigen (HA) and challenged with SRC. Isophilic immune responses were almost completely suppressed. Kinetics of the primary and secondary immune responses were analyzed. Intervals of two to four days between administration of HA and SRC yielded maximal suppression. Primary immune responses to SRC were determined in cultures of splenic cell suspensions derived from rats which had been either injected in vivo with HA or received no treatment. Under these conditions, too, administration of HA interfered with the antibody responses to SRC. Both adherent and nonadherent cells caused inhibition, with this property appearing earlier in adherent than in nonadherent cells. A hypothesis, capable of explaining the observations made in this study and compatible with similar phenomena described in other systems, has been proposed according to which after immunization with HA, SRC are diverted to HA-stimulated cells which are not equipped to deal with the antigen complex represented by SRC.

Animals↗