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Biomedical subjects

K Sorensen

Publications and source records attributed to K Sorensen.

At least 91 records · Page 5Linked to original sources
PubMed1975

A comparative evaluation of the treatment of typhoid fevers with co-trimoxazole and chloramphenicol in Egypt.

Seventy-two patients with bacteriologically proven enteric fever were treated with either co-trimoxazole (41 cases) or chloramphenicol (31 cases). C0-trimoxazole was found to be superior to chloramphenicol in relieving the toxaemia. The average number of days required for patients to become afebrile was 5-5 days in the co-trimoxazole group and 4-5 days in the chloramphenicol group. The cure rate was 97 per cent in each of the treatment groups. There occurred two relapses in the co-trimoxazole group and four relapses in the chloramphenicol group. No side effects of the co-trimoxazole were detected during the study. Co-trimoxazole can be considered as a good alternative to chloramphenicol in the treatment of the enteric fevers.

Adolescent↗
PubMed1975

Transmission of hepatitis B to the rhesus monkey.

The rhesus monkey does provide a suitable laboratory animal model for studying hepatitis B virus and for investigating various aspects of interaction between this infectious agent and the host. This species of non-human primate, however, offers a less sensitive animal model for hepatitis B infection than the chimpanzee.

Animals↗
PubMed1972

Concentrations of ampicillin and chloramphenicol in the serum of patients with acute Salmonella enteric fever.

Concentrations of ampicillin and chloramphenicol were measured in the serum of patients being treated for acute infections by Salmonella typhi or S. paratyphi A. Ampicillin was administered by the oral or intramuscular routes, whereas chloramphenicol was given orally only. Ampicillin concentrations were highest 1 hr after initiation of intramuscular therapy and 2 hr after oral administration. The serum concentration of ampicillin was significantly higher when it was given intramuscularly than when it was given orally. However, serum concentrations in orally treated patients were approximately the same at 1 hr after the fifth dose as they were 1 hr after the first dose, in contrast to intramuscularly treated patients, in whom the serum concentration of ampicillin was significantly lower 1 hr after the fifth dose. On the other hand, serum concentrations of chloramphenicol were significantly higher after the fifth dose than after the first dose. The rates of cure, relapse, and drug treatment failure were similar for all treatment regimens, and the drug concentrations attained in serum were generally above the minimal inhibitory concentration for the infecting salmonellae.

Adolescent↗
PubMed1971

Trimethoprim-sulphamethoxazole in acute brucellosis.

Eight patients with proved brucella infection were treated with trimethoprim-sulphamethoxazole. The dose varied from two to four tablets given twice daily for three weeks. Clinical response was rapid and all patients were asymptomatic and afebrile within two to seven days of starting therapy. Three patients relapsed clinically and bacteriologically within three weeks of ending treatment. There were no side effects of the treatment. It is suggested that the treatment be continued for at least six weeks to prevent relapses.

Adolescent↗