PubMed · 4484014
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K Sorensen. 1972-01-27. [Nurses' tax returns].. https://pubmed.ncbi.nlm.nih.gov/4484014/
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BACKGROUNDIncreasing incidence rates of invasive Streptococcus dysgalactiae subspecies equisimilis (iSDSE) have been detected worldwide.AIMWe aimed to investigate iSDSE infection incidence rates in Denmark during 2014-2024, and characterise the genomic population structure of a subset of iSDSE isolates and their antimicrobial resistance (AMR).METHODSUsing national register data, we estimated overall and sex-/age-stratified iSDSE incidences during 2014-2024, by retrospectively identifying cases of invasive infections with group C and G streptococci or S. dysgalactiae (including specified as subspecies equisimilis). From the voluntary national beta-haemolytic streptococci laboratory surveillance system, whole-genome-sequenced isolates from August 2020-September 2022 were used to investigate the iSDSE genomic population structure. Susceptibility to penicillin, erythromycin and clindamycin was determined and AMR genes identified.RESULTSDuring 2014-2024, iSDSE incidence rates increased significantly (linear trend analysis p < 0.001) with mean annual incidence ranging between 10.3 and 16.4 per 100,000, peaking in 2023. Incidence was higher in males, increasing with older age. Nearly 75% of the 1,223 iSDSE isolates belonged to four of 14 genetic clusters. Sequence types (STs) ST20 and ST17 were most prevalent, while emm-type stG62647, a variant associated internationally with higher virulence, dominated. All isolates were phenotypically susceptible to penicillin but approximately 10% were respectively erythromycin and clindamycin resistant. High erythromycin resistance prevalence (57%; 39/68), coinciding with gene ermA, occurred in one genetic cluster.CONCLUSIONThe findings illustrate the need for national registry-based surveillance to detect epidemiological changes and potential outbreaks. Further, continuous genomic surveillance can monitor the occurrence and expansion of genetic clades and AMR genes.
Drugs (n = 2240) seized on the illicit drug market in the Aarhus Police District during the period 1.1.1992-31.12.1993 are described with regard to weight, identity, purity and distribution. This article dealing with drugs together with the article dealing with the "actors" are reviews of results published in book form (English summary) (1). Two thirds of the samples were cannabis, mainly hash. Medical prescription drugs, mainly benzodiazepines, constituted 11% of the samples. Amphetamine was found in 9% of the samples and heroin in 8%. Cocaine and other euphoriants were each found in less than 1% of the samples. The purity of all types of drugs varied greatly during the study period, good and poor quality drugs being available on the market at the same time. No difference was found between the purity of drugs in user packages and that of drugs in large packages. Most batches were on the market only for a brief period of time. It is concluded that it is difficult for users to obtain the same quality of a substance each time.
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