Rhabdomyoma is the most common primary cardiac tumor in infants and children and is often associated with tuberous sclerosis. Surgical resection may be indicated and, if so, is usually curative. We describe a rhabdomyoma in an infant who presented with severe myocardial ischemia necessitating orthotopic heart transplantation.

Diagnosis, Differential↗

PubMedDate not supplied

Weight watchers.

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Dietetics↗

PubMedDate not supplied

Castleman's disease: cytomorphologic and cytochemical features of a case.

The cytomorphologic features of a case of giant lymph node hyperplasia, hyaline-vascular type, obtained by fine needle aspiration is described. Cytochemical studies of the vascular structures present in the aspirate suggest their origin as capillaries.

Aged↗

PubMedDate not supplied

Uterine Müllerian adenosarcoma with psammoma bodies: cytologic, histologic and ultrastructural studies of a case.

Epithelial cells associated with psammoma bodies and undifferentiated sarcomatous tumor cells were found in peritoneal washings obtained during laparotomy for removal of metastatic lesions from a uterine stromal sarcoma. Histologic studies of the primary and recurrent tumors showed characteristics of Müllerian adenosarcoma. The cytologic, histologic and ultrastructural features are described.

Adult↗

PubMedDate not supplied

Pale nodular nuclei not diagnostic of adenocarcinoma of the pancreas.

Pale nodular nuclei have been described as a possible marker that is found only in pancreatic adenocarcinoma. Our analysis of cytologic samples of tumors from a variety of organs of distinctive histologic types disclosed the presence of these nuclei in cells from malignancies other than adenocarcinoma of the pancreas.

Adenocarcinoma↗

PubMedDate not supplied

Incidence of obliterative bronchiolitis after heart-lung transplantation in children.

Between June 1988 and February 1993, combined heart-lung transplantation was performed in 30 children and adolescents aged 3.6 to 18.6 years (mean, 12.2 years) at The Hospital for Sick Children in London. Original diagnoses included cystic fibrosis (n = 25), Eisenmenger's syndrome (n = 4), and chronic graft-versus-host disease of the lung (n = 1). Posttransplantation maintenance immunosuppression comprised a triple regimen, with methylprednisolone and antithymocyte globulin given perioperatively and for episodes of allograft rejection. Actuarial survival was 63% (95% confidence interval: 42%-78%) at 1 year and 48% (95% confidence interval: 27%-66%) at 3 years. Obliterative bronchiolitis has been diagnosed in 13 patients (43%). Actuarial freedom from obliterative bronchiolitis in survivors was 76%, 59%, and 37% at 12, 24, and 36 months after transplantation, respectively. Recipients in whom obliterative bronchiolitis developed within the first year (n = 6) had more episodes of pulmonary rejection during the first 6 months after transplantation (mean, 5.7 episodes per patient) than those in whom "premature" obliterative bronchiolitis did not develop (mean, 3.2 episodes per patient). Infection of the pulmonary allograft was implicated to a lesser extent in predisposing to obliterative bronchiolitis. At 2, 3, and 6 months, tracheal stenosis developed in three patients, all of whom died with obliterative bronchiolitis within 10 months of transplantation. Noncompliance with therapy was considered a contributory factor in producing obliterative bronchiolitis in four adolescent recipients. The high incidence of obliterative bronchiolitis observed in this pediatric cohort may have a multifactorial cause.

Actuarial Analysis↗