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Biomedical subjects

K Rudolf

Publications and source records attributed to K Rudolf.

At least 73 records · Page 4Linked to original sources
PubMed1985

[Effect of ethinyl estradiol sulfonate/norethisterone acetate on PRI secretion in pubertal girls].

In 13 healthy tall girls the influence of the hormonal treatment with depotestrogen ethinylestradiolsulfonate and norethisterone acetate was investigated on the basal and TRH stimulated PRL secretion. The investigations were performed before treatment, during the 8th to 11th cycles of treatment, and in the 4th month after finishing the therapy. PRL levels were determined by RIA. Under treatment significant higher basal PRL levels were found than before (p less than 0.05), but never hyperprolactinemic values. The responsibility of the lactotropic cells to TRH stimulation was increased, too.

Adolescent↗
PubMed1985

[Effect of ethinyl estradiol sulfonate/norethisterone acetate on HGH secretion in pubertal girls].

In 13 healthy tall girls the influence of the hormonal treatment with depotestrogen ethinylestradiolsulfonate and norethisterone acetate was investigated on basal and arginine stimulated HGH secretion. The investigations were performed before, during and after finishing the therapy. HGH serum levels were determined by RIA. During the hormonal therapy the mean basal HGH levels were significant higher (p less than 0.05) than before or after therapy. Independent from hormonal therapy there was no stimulation of the HGH secretion by arginine in about 2/3 of the girls.

Adolescent↗
PubMed1985

[Effect of ethinyl estradiol sulfonate/norethisterone acetate on TSH, T4, TBC and the FT4 index in pubertal girls].

In 13 healthy tall girls the influence of the hormonal treatment with depotestrogen ethinylestradiolsulfonate and norethisterone acetate on basal and TRH stimulated TSH secretion, total thyroxine (T4), thyroxine binding capacity (TBC) and free thyroxine index (FT4 index) was investigated. The investigations were performed before treatment, during the 8th to 11th cycles of treatment, and in the 4th month after finishing the therapy. TSH and T4 serum levels were determined by RIA, TBC by radio agent assay, the FT4 index was calculated. The mean basal TSH levels before, during and after therapy showed no significant differences. During hormonal therapy T4, TBC and FT4 were significant higher (p less than 0.05) than before and after therapy.

Adolescent↗
PubMed1985

[Behavior of the hypothalamo-hypophyseal unit to stimulation with arginine, GnRH and TRH in patients with chronic uremia].

In 11 women aged from 20 to 47 years (average age 33,1 years) with chronic uremia, treated by hemodialysis, a sequential stimulation test (SST) with 0.5 g arginine hydrochloride per kg body weight, 25 micrograms GnRH and 200 micrograms TRH was performed to examine the responsibility of the hypothalamo-pituitary unit. For evaluation of basal and stimulated secretion of PRL, LH, FSH, TSH, and HGH the corresponding serum levels were determined by RIA. 10 of the 11 women showed a galactorrhoea. No correlation between levels of PRL and creatinine could be found. Menstrual disorders in women with chronic uremia are discussed in the context of basal LH serum levels nearly always unphysiologically increased. In a few cases disturbances of basal secretion of TSH and HGH, respectively, could be observed.

Adult↗
PubMed1984

The effect of a single midcycle administration of 0.5 or 2.0 mg dienogest (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4,9-dien-3-one) on pituitary and ovarian function--investigation for the use as a postcoital contraceptive.

Estradiol-17 beta, progesterone, LH and FSH levels in plasma were measured simultaneously by radioimmunoassay and BBT was recorded in order to investigate the effect of a single midcycle oral dose of 0.5 or 2.0 mg dienogest (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4,9-dien-3-one, VEB Jenapharm, Jena/GDR) on pituitary and ovarian function in 18 healthy fertile females. After application of 0.5 mg dienogest in the follicular phase the cycles appeared to be anovulatory. Administration of 2.0 mg two days prior to the expected LH-surge produced a delay of the LH-peak combined with an absence of ovulation as well as the absence of the normal subsequent increase of progesterone. With 0.5 mg the delay of the LH-surge was followed by an ovulation with normal corpus luteum function. The application of 0.5 or 2.0 mg one day before or during the rising LH-peak lowered the LH-surge but ovulation and luteal phase were not altered. Administration of both dosages during the LH-peak could neither prevent ovulation nor disturb corpus luteum function. Postovulatory ingestion of 0.5 or 2.0 mg dienogest during the BBT-rise produced no alteration of the further cycle. These results demonstrate that dienogest in a single-dose-administration in midcycle can alter pituitary and ovarian function depending on the time interval between application and the day of LH-surge.

Adult↗
PubMed1984

[Methods of ovulation induction].

Basing on the mechanism of the endocrine regulation of the reproductive events in the women causes and therapy of the endocrine sterility are discussed. Causes of endocrine sterility are divided into the entities hyperprolactinemic, hyperandrogenemic, hypo- and dysgonadotropic hypogonadism. Concerning these disturbances the specific therapeutic opportunities with the inhibitor of the prolactin secretion, with antiandrogenes, corticosteroids, antiestrogens, gonadotropins or gonadotropin-releasing hormone, respectively, are summarized. With a proposed scheme for diagnostic and therapeutic use an effective and economic proceeding in the treatment of the endocrine caused female sterility is intended.

Androgen Antagonists↗
PubMed1984

[Recent findings on follicle and oocyte maturation. 1. Development of follicles and maturation of follicles].

A review is given of the present knowledge of the development of follicles and oocytes, especially in the human. The first report deals with the course of development of follicles from the beginning in the fetal ovary to the mature Graafian follicle in the adult women. Questions of terminology, functional morphology and important aspects of the regulation of follicular growth are discussed. The last part of the paper summarizes the present day possibilities in monitoring growth and maturation of ovarian follicles in clinical practice.

Androstenedione↗
PubMed1983

[Results of treatment of functional sterility with clomifen].

Our experiences in the treatment of functional sterility in 482 patients with clomiphene are reported. The dosage of clomiphene was 100 mg per day for 5 days. If treatment was without success after 3 cycles dosage was changed to 150 mg per day for 7 days. The ovulation induction rate detected by basal body temperature was 74.5%. Conceptions were obtained in 35.7%. Pregnancy was terminated by spontaneous abortion in 18.8%. In high weight patients there was the best success rate with clomiphene treatment.

Adult↗
PubMed1982

[The indocyanine green (Ujoviridin) test in patients with hyperemesis gravidarum].

A dose of 0.5 mg/kg body weight of indocyanine-green (Ujoviridin), a chromodiagnostic, was applied in one single injection under standardised conditions to 16 patients, aged between 21 and 31 years (25.9 years on average), with slight to moderate hyperemesis gravidarum, with the view to making an assessment of hepatic excretion.--Also determined were aminotransferases, alanine-aminopeptidase, and bilirubin in serum, accompanied by thymol turbidity tests.--The values of indocyanine-green half-life were all, but for one patient, within or at the upper limit of normal.--While the informative value of individual measurements is limited, the above findings seem to suggest that in cases of slight or moderate hyperemesis the laboratory parameters tested are unlikely to rise to pathological levels, except for slight increases which may be associated to certain individual cases.

Adult↗
PubMed1982

Thyrotropin, total thyroxine, thyroxine binding capacity and free thyroxine index in patients with gonadal dysgenesis (karyotype 45/XO).

In 9 patients with gonadal dysgenesis (karyotype 45/XO), the responsiveness of thyreotropic cells of the pituitary was investigated by stimulation with thyreotropin-releasing hormone (TRH). Both after hormone substitution in the form of sequential therapy (mestranol/mestranol-chlormadinone acetate) and after the end of therapy the investigations were repeated. TSH was determined by RIA, total thyroxine and binding capacity of thyroxine binding globuline (TBC-index) by protein binding assay. The free thyroxine index (FT4-index) was calculated. The results show that the hypothalamic-pituitary unit in patients with gonadal dysgenesis reacts in a similar manner as in normal female subjects.

Adolescent↗
PubMed1982

[Behavior of the hypothalamo-hypophyseal axis in a patient with asymmetric mixed gonadal dysgenesis (chromosome pattern 45,XO/46,XY) before and after gonad excision after with arginine, GRH and TRH stimulation].

In a 12 years old patient with asymmetric mixed gonadal dysgenesis (karyotype 45, XO/46,XY) a stimulation test with arginine, gonadotropin-releasing hormone (GRH) and thyreotropin-releasing hormone (TRH) was performed before and after exstirpation of the gonads as well as after application of sex steroids. FSH, LH, PRL, HGH, TSH, testosterone and oestradiol were determined by radioimmunoassay. The results show an intact hypothalamo-pituitary axis which reacts with a normal negative feedback with respect to the secretion of gonadotropins after application of sex steroids.

Arginine↗
PubMed1980

[Stimulation test of the adenohypophysis with arginine, gonadotropin-releasing hormone (GRH), and thyrotropin-releasing hormone (TRH) in 45, XO patients with Turner's syndrome (author's transl)].

Pituitary stimulation tests with arginine, gonadotropin-releasing hormone (GRH) and thyrotropin-releasing hormone (TRH) were performed in five 45, XO patients with Turner's syndrome. Their ages ranged from 12--17 years. Serum levels of LH, FSH, PRL, HGH, and TSH were measured by RIA. The hypothalamo-pituitary system appeared normal in the patients with Turner's syndrome.

Adolescent↗
PubMed1980

[Continuous intravenous infusion of insulin to girls with hereditary tall growth and secretion of human growth hormone, prior to and during Deposiston treatment (author's transl)].

Continuous intravenous insulin infusion tests, accompanied by growth hormone determination, were applied to 40 girls of tall growth whose final lengths were predicted to be in excess of 181 cm. The girls were aged between nine and half and 14 years and one month, all of them being in the premenarchic phase. The tests were conducted prior to and following at least one year of Deposiston therapy (oestrogen/gestagen). - Really effective inhibition of growth (7.4 +/- 0.6 cm) was obtained only from five girls, aged between nine years and ten months and eleven years, in whom basal secretion of HGH was lower with significance than that of the whole group, with their stimulation reaction being fully retained. Secretion of somatotropic hormone (STH) of the other girls remained unaffected, prior to and following treatment. The weekly oestrogen dose of 1 mg was relatively low, when compared to propositions made by other authors, but it seemed to be justified by the average reduction in expected final body length obtained for the probands reviewed (5.4 +/- 2.0 cm).

Adolescent↗