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Biomedical subjects

K Rudolf

Publications and source records attributed to K Rudolf.

At least 55 records · Page 3Linked to original sources
PubMed1988

[Basal and gonadotropin releasing hormone-stimulated gonadotropin secretion in patients with chronic uremia].

In 11 patients with chronic uremia both the basal and stimulated levels of LH and FSH in serum were determined by RIA. After renal transplantation the investigations were repeated in 2 cases. The basal levels of LH were unphysiologically increased whereas FSH was found in the normal range. The stimulation of LH by GnRH was adequate in 6 patients and in 5 there was no response. As a result of renal transplantation there was a drop of LH in serum. It is supposed that the unphysiological increase of LH in patients with chronic uremia is the cause for the disturbances of the menstrual cycle.

Adult↗
PubMed1988

[Basal and TRH stimulated TSH secretion and determination of total thyroxine (T4). Thyroxine-binding capacity and free thyroxine index (FT4-I) in patients with chronic uremia].

In 11 patients with chronic uremia both the basal and TRH stimulated TSH levels and T4, TBC and FT4-I were determined. The investigations were repeated in 2 cases after renal transplantation. TSH and T4 in serum were determined by RIA, TBC by radio reagent assay. FT4-I was calculated. In 8 patients the basal TSH levels were in the normo- and in 3 in the hypothyreotropic range. In 9 patients the response to TRH was adequate. There were deviations from the physiological range in 7 patients for T4 and in 6 for FT4-I.

Adult↗
PubMed1988

[Basal and stimulated secretion of prolactin and growth hormone in patients with chronic uremia].

In 11 patients with chronic uremia both the basal and the stimulated levels of PRL and HGH were determined by RIA. The investigations were repeated in 2 patients after renal transplantation. The basal PRL levels were as well hyper- and normoprolactinemic as hypoprolactinemic. Also the PRL response did not show any uniform tendency to the TRH stimulation. After renal transplantation in 1 patient there was a decrease of the hyperprolactinemic serum levels into the normoprolactinemic range whereas the response was not influenced to TRH. Both the basal and the stimulated levels of HGH were in the physiological range. The response of HGH to the stimulation is explained as the so-called paradox TRH effect underlined by missing of the stimulation after renal transplantation.

Adult↗
PubMed1988

[Effect of sulprostone on prolactin, HPL, HCG, progesterone and estradiol serum level in abortion induction in the first trimester in primigravidae].

The influence of the i.m. application of Sulproston for induction of abortion was examined on the serum levels of PRL, HCG, HPL, estradiol and progesterone in 8 primigravidae during the first trimenon. The hormones were determined by RIA. There was a drop of HCG, HPL, estradiol and progesterone beginning 4 to 16 hours after the first application of Sulproston. PRL was not influenced.

Abortifacient Agents↗
PubMed1987

[Results of the GnRH-TRH and arginine-GnRH-TRH test in females with hyperprolactinemic galactorrhea].

In 7 patients aged from 21 to 33 years (average age 24.6 years) with hyperprolactinemic galactorrhea a stimulation test with GnRH-TRH or arginine-GnRH-TRH was performed. The serum levels of LH, FSH, PRL, HGH, TSH and total thyroxine (T4) were determined by RIA, the thyroxine binding capacity (TBC) by radio agent assay. The free thyroxine index (FT4-I) was calculated. An adenoma of the pituitary gland was diagnosed in 3 patients by X-ray of sella turcica. In all patients there were disturbances of the menstrual cycle. Independent of the existence of an adenoma of the pituitary gland in all patients with high basal levels. PRL could not have been shown stimulated by TRH. On the other hand it could be shown that despite of high basal PRL-levels in serum there was a normal stimulation of the gonadotrophs in 5 patients. Out of one patient the stimulation of the thyreotropic cells of pituitary by TRH was normal, too, whereas there was no or an inadaquate stimulation of HGH by arginine in all patients.--T4, TBC and FT4-I showed no deviation from the normal range.

Adenoma↗
PubMed1987

[GnRH-TRH and arg-GnRH-TRH test in females with normoprolactinemic galactorrhea].

In 8 patients aged from 17 to 48 years (average age 32,6 years) with normoprolactinemic galactorrhea a stimulation test with GnRH-TRH or arginine-GnRH-TRH was performed. The basal and stimulated serum levels of LH, FSH, PRL, TSH, HGH and total thyroxine (T4), the thyroxine binding capacity (TBC) and the free thyroxine index (FT4-I) were determined. -In a few cases there were disturbances of both the basal and the stimulated serum levels of the hormones. -Both the menstrual disorders which were seen in all patients with galactorrhea and the hormonal disturbances are discussed in context of an hypothetical increase of the PRL receptor sensibility in face of normal PRL serum levels or as a hint at a transient hyperprolactinemia.

Adolescent↗
PubMed1987

[Experiences with the use of sulprostone (Nalador) for the termination of pregnancy in the 1st trimester in primigravidae].

Sulprostone in different doses and application forms (25, 50 or 100 micrograms extra-amnionic; 500 micrograms or 3 times 500 micrograms every 4 hours intramuscularly) was given to perform termination of pregnancy between 7th and 12th week. The dose of 500 micrograms three times given was most effectiveness, but there were the most side effects, too. The dose of 500 micrograms Sulproston was accompanied by less side effects and the therapeutic success was sufficient. The extra-amnionic application was effective also in all used dosages.

Abortifacient Agents↗
PubMed1987

[Comparative coagulation studies in induced therapeutic abortions with prostaglandin].

Therapeutic abortion in the first trimester of pregnancy have been done in ten primigravidae using PGF2 alpha, 15-methyl-PGF2 alpha, or Sulprostone. Bleeding and recalcification time, platelet count, fibrin, platelet adhesiveness, partial thromboplastin time and thromboplastin time were examined before, during and after treatment. We found a decrease of platelet count and a prolongation of bleeding and recalcification time. There was no intensive-influence on coagulation system by the prostaglandin used. Therefore prostaglandins may be used for therapeutic abortion.

Abortifacient Agents↗
PubMed1986

[Effect of mestranol and chlormadinone acetate on TSH, T4, TBC and FT4 index in Turner syndrome].

In 19 patients with Turner's syndrome aged from 12 to 24 years (average age 17.0 years) the influence of mestranol and chlormadinone acetate on both basal and TRH stimulated TSH secretion, total thyroxine (T4), thyroxine binding capacity (TBC) and free thyroxine index (FT4-I) by means of sequential stimulation test (0.5 g arginine hydrochloride/kg body weight, 25 micrograms GnRH and 200 micrograms TRH) was investigated. These investigations were performed before hormonal substitution, during third to 5th cycles of treatment and 4 month after finishing treatment. TSH and T4 serum levels were determined by RIA, TBC by radio reagent assay. The FT4 index was calculated. Mean basal TSH levels both before, during and after hormonal treatment did not differ. Netto TSH level increase were somewhat higher in 8 of the 19 patients during hormonal treatment. TBC and T4 significantly increased under treatment. The rise of FT4 in a few patients under treatment could not be ensured statistically. After finishing treatment the levels of thyroid parameters decreased.

Adolescent↗
PubMed1985

[Effect of mestranol and chlormadinone acetate on basal and GnRH stimulated gonadotropin secretion in Turner's syndrome].

In 19 patients aged from 12 to 24 years (average age 17.0 years) with Turner's syndrome the influence of mestranol and chlormadinone acetate on both basal and GnRH stimulated secretion of gonadotropins was investigated by means of sequential test (0.5 g arginine hydrochloride/kg body weight, 25 micrograms GnRH and 200 micrograms TRH). This test was performed before, during and after treatment. Serum levels of LH and FSH were determined by RIA. Before hormonal treatment 15 patients showed hypergonadotropic, and 4 normo- or hypogonadotropic basal levels, respectively. By GnRH the increase of the gonadotropin secretion was individually different. Under hormonal influence the basal gonadotropin levels were significantly reduced, with the responsibility to GnRH going lost. After treatment in 15 women hypergonadotropic levels were recovered. But FSH serum levels were somewhat lower and LH levels somewhat higher than before hormonal treatment.

Adolescent↗
PubMed1985

[Effect of mestranol and chlormadinone acetate on basal and TRH-stimulated PRL secretion in Turner's syndrome].

In 19 patients aged from 12 to 24 years (average age 17.0 years) with Turner's syndrome the influence of mestranol and chlormadinone acetate on both basal and TRH stimulated PRL secretion was investigated by means of sequential stimulation test (0.5 g arginine hydrochloride/kg body weight, 25 micrograms GnRH and 200 micrograms TRH). This test was performed before, during the third until 5th cycle of treatment and 4 month after the end of therapy. PRL levels were determined by RIA. In most patients under treatment both basal and stimulated PRL showed an increase within the normal range. Hyperprolactinemic levels could be observed on one patient only.

Adolescent↗
PubMed1985

[Effect of mestranol and chlormadinone acetate on HGH secretion in Turner's syndrome].

In 19 patients aged from 12 to 24 years (average age 17.0 years) with Turner's syndrome the influence of the hormonal substitution with mestranol and chlormadinone acetate on both basal and arginine stimulated HGH secretion was investigated. This test was performed before, during and after treatment. HGH serum levels were determined by RIA. Both the basal values and the increase of HGH secretion after arginine stimulation were used for evaluation of the test results. Under estrogen-gestagen treatment in 15 of the 19 patients hypersomatotropic basal levels were determined. The basal HGH levels before and during as well as during and after treatment are significant different (p less than 0,01). The responsibility of the somatotrophs to the arginine stimulation was individually different and did not show any uniform trend.

Adolescent↗
PubMed1985

[The coincidence of gonadal dysgenesis and hyperprolactinemia].

It was reported about 6 female patients aged from 3 to 31 years (average age 18 years) with gonadal dysgenesis and hyperprolactinemia. Beside one all these females were not treated with synthetic sexual steroids. In 5 of the 6 patients both hyperprolactinemic and hypergonadotropic serum levels were observed. In one case the gonadotropic serum levels were normal. In 4 patients a stimulation test with GRH-TRH or Arg-GRH-TRH, respectively, was performed. In patients with gonadal dysgenesis a change on the area of the hypothalamic-hypophyseal axis is supposed to cause the hyperprolactinemia.

Adolescent↗
PubMed1985

[Primary hyperprolactinemic amenorrhea. Report of 4 patients].

Report about 4 female patients with hyperprolactinemic primary amenorrhea. In two of these women there was a suspicion of adenoma of hypophysis. In the stimulation test with gonadotropin-releasing hormone and thyrotropin-releasing hormone in two females the very high basal PRL secretion could not have been stimulated in one case. In the other case the TRH-stimulated PRL serum levels increased. Biphasic menstrual cycles resulted by therapy in two females treated with bromoergocryptine.

Adenoma↗
PubMed1985

[Arginine-GnRH-TRH test in patients with primary hypothalamic amenorrhea].

In 8 patients with hypothalamic primary amenorrhea aged from 16 to 23 years (average age 19,4 years) a sequential stimulations test was performed with 0,5 g arginine hydrochloride per kg body weight, 25 micrograms gonadotropin-releasing hormone (GnRH) and 200 micrograms thyreotropin-releasing hormone (TRH). The response of the lactotropic, gonadotropic, thyreotropic and somatotropic cells of the pituitary was investigated. Serum levels of PRL, LH, FSH, TSH and HGH were determined by RIA. In all women hypoplastic ovaries were found by laparoscopy. In 7 patients tissue biopsies showed primordial follicles or primordial and secondary follicles, respectively. Investigations point to, that in hypothalamic primary amenorrhea at first the function of the gonadotropic and lactotropic cells of the pituitary is injured. The somatotropic cells could not be stimulated in 3 of 8 patients, the function of hypothalamo-pituitary-thyroid-axis in the stimulations test was normal in all women.

Adolescent↗
PubMed1985

[Theoretical principles and personal experiences in the use of a sequential stimulation test with arginine, gonadotropin-releasing hormone and thyrotropin-releasing hormone in healthy probands].

The theoretical bases and the performance of a sequential stimulation test (SST) with 0.5 g arginine hydrochloride per kg body weight, 25 micrograms gonadotropin-releasing hormone and 200 micrograms thyreotropin-releasing hormone are described. The result of SST is shown for 17 healthy women with biphasic cyclus. Beside the basal hormone levels B (hypo-, normo- or hyperhormonal) the response A (no, inadaquate or adaquate response) to the stimulation resulting from the peak levels and netto increases is a valuation criteria.

Adolescent↗
PubMed1985

[Effect of ethinyl estradiol sulfonate/norethisterone acetate on gonadotropin secretion in pubertal girls].

In 13 healthy tall girls the influence of the hormonal treatment with depotestrogen ethinylestradiolsulfonate and norethisterone acetate on basal and GnRH stimulated gonadotropin secretion was investigated. The investigation were performed before treatment, during the 8th to 11th cycles of treatment, and in the 4th month after finishing the therapy. LH and FSH serum levels were determined by RIA. Under treatment a suppression both of basal gonadotropin serum levels and of the stimulated LH secretion results. After treatment the mean basal gonadotropin levels are higher than before or during the therapy. The LH release after GnRH stimulation shows the same trend.

Adolescent↗