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Biomedical subjects

K Rudolf

Publications and source records attributed to K Rudolf.

90 records · Page 5Linked to original sources
PubMed1980

[Use of PGF2 alpha to induce abortion in patients with risk factors in first and second thirds of gravidity (author's transl)].

Reported in this paper is the use of PGF2 alpha to induce legal abortion in 43 patients with uterine risk factors (Group 1) or with general diseases manifest before (Group 2). The abortions were induced between the eighth and 24th weeks of pregnancy. PGF2 alpha was applied extra-amniotically, intra-amniotically or by combined approach, that is intra-amniotic or intravenous with extra-amniotic. - Twenty-seven women were included in Group 1, and in 25 of them pregnancy was disrupted without any complications. Complete expulsion of foetus and placenta, caused by rupture in the posterior labium of the os uteri, occurred to one of the patients with myomatous uterus. Acute ascension developed in another patient, three days from the intervention. - Group 2 was composed of 16 patients. Induced abortion was without any complications in 15, while one patient with psychosomatic epilepsy had an epileptic fit. Her pregnancy had to be terminated by hysterotomy. - The use of PGF2 alpha is considered an effective method to induce abortion in patients with risk factors.

Abortion, Therapeutic↗
PubMed1979

The gonadotropin releasing hormone stimulation and the clomiphene tests in female patients with anorexia nervosa.

In 9 female patients suffering from acute anorexia nervosa (a.n.) and in two patients in whom this disease had reached the remission phase, the response of the gonadotropin-producing cells in the adenohypophysis was checked by administration of Gn-RH and the degree to which the hypothalamic-hypophyseal axis could be stimulated was checked by administration of clomiphene (5 x 100 mg). Hormonal screening examinations (cervical score after Insler and hormonal vaginal cytology) were used to assay the basal estrogen production. LH and FSH concentrations in the serum were determined radioimmunologically using the principles of the double antibody technique. The gonadotropin-producing cells did not respond to Gn-RH administration in 8 of the 9 patients with acute a.n. The response was disturbed in one of these patients. The response to Gn-RH stimulation was normal in the two patients in the remission phase. Clomiphene had no stimulatory effect on the hypothalamic-hypophyseal axis during either the acute or remission phase. Hormonal treatment during the acute phase of a.n. is not indicated since, after recovery of a normal body weight, the symptoms recede and the cycle normalises spontaneously.

Adolescent↗
PubMed1979

Extraamniotic intermittent administration of prostaglandin F2 alpha during the first and second trimesters of pregnancy.

Extraamniotic application of prostaglandin F2 alpha (PGF2 alpha) was used for legal abortion in the series of 1012 women. The pregnancies were terminated by abortion between the 6th and 27th weeks of pregnancy. In 86.7% of the cases, intermittent extraamniotic application of PGF2 alpha led to complete or incomplete abortions. Of the 26 failures, nine were caused by technical difficulties. In 17 primigravidae, the cervical canal remained closed. There were no statistically related differences between the different weeks of the pregnancy with regard to success and failure rates. The mean PGF2 alpha dose and abortion time increased significantly (p less than 0.01) with increasing duration of pregnancy. 80% of the patients suffered from undesirable side effects. The morbidity rate for the period up to six weeks following the abortion was 3.2%.

Abortion, Incomplete↗
PubMed1977

[Therapeutic induction of abortion in the 1st and 2nd trimesters with intramuscular 15-methyl-prostaglandin F2 alpha].

The effectiveness of intramuscular 15-methyl-prostaglandin F2alpha (15-methyl-PGF2alpha) application for therapeutic abortion was studied in 16 women during the first and second trimester (12 to 17 weeks) of pregnancy. 250 microgram 15-methyl-PGF2alpha were administered initial and at intervals of 2 hours. Of the 16 subjects, 2 aborted completely, 13 aborted incompletely and 1 failed to abort. The mean abortion time for the 15 successful abortions was 11,25 hours and the mean 15-methyl-PGF2alpha dosage 1,35 mgs. Vomiting and diarrhea were the most prevalent side effects occurring in 12 of 16 patients. No serious complications occurred. In 9 women between 7 to 13 weeks of pregnancy a single intramuscular injection of 250 microgram 15-methyl-PGF2alpha was administered 11 to 13 hours prior to vacuum aspiration. All subjects had a gradual softening and dilatation of the cervix (5 to 8 mm). In 7 of 9 patients occurring gastro-intestinal side effects. Acute ascension was observed in 2 women after vacuum aspiration. All subjects had a gradual softning and dilatation of the cervix (5 to 8 mm). In 7 of 9 patients occurring gastro-intestinal side effects. Acute ascension was observed in 2 women after vacuum aspiration. Intramuscular administration of 15-methyl-PGF2alpha appears to be an effective abortifacient. Gastro-intestinal side effects can be reduced by antiemetic and antidiarrheal agents or lowering the initial dose of 15-methyl-PGF2alpha.

Abortion, Therapeutic↗
PubMed1977

[Assessment of liver function using indocyanine green (Ujoviridin) during normal pregnancy, during labor and in puerperium].

Indocyaningreen (ICG) was given for the characterize of the excretion function of the liver during the course of normal pregnancy, sub partu and post partum. Studies were performed in 168 primi- and multigravidas with normal medical and obstetric histories (mean age of 23,5 years). 0,5 mg ICG/kg body mass were injected intravenously as a bolus. 18 healthy nonpregnant women served as controls (mean age of 24,2 years). In the I. and II. trimester of pregnancy the elimination of ICG was not decreased in comparison to the controls (3,64 +/- 0,86). The increased retention of ICG in the 40th week of pregnancy (4,67 +/- 0,41) and during labor (7,02 +/- 2,32) are caused through the physiological alterations of pregnancy. No placental transfer of the dye could be detected by simultaneous measurement of ICG in the maternal and fetal cord blood. During the post partum period the elimination of ICG will be normal. ICG is recommend instead of Bromsulfaleine (BSP) for the estimation of excretion function of the liver during pregnancy and childbed.

Adolescent↗
PubMed1976

[The course of total leukocytes and heparinocytes in the normal puerperium and during weaning under ethinyl estradiol sulfonate].

The inhibition of lactation by the depot oestrogen aethinyloestradiolsulfonate was accompanied by a delayed drop of the puerperal leukocytosis. Values of heparinocytes and Basophil-Age-Indices (BAI) were not significantly influenced. The reaction of the heparinocytes system is different in increasing classes of age. By depotoestrogens in the puerperium the princip of this reaction is not changed. Results don't support the hypothesis of influence of oestrogens upon puerperal and hormonal contraception risks of thromboembolism.

Basophils↗
PubMed1976

[Intrauterine extra-amnial administration of prostaglandin F 2 alpha for the induction of abortion in primigravidae and problem cases].

With 529 patients (4 groups) abortion was induced through intermittend extraamniotic application of PGF2alpha. In 97,9 per cent, the hourly instillation of PGF2alpha led to the desired success: 25 (4,7 per cent) complete abortions, 416 (78,6 per cent) incomplete abortions, 77 (14,6 per cent) "missed" abortions with opening of the cervix. In groups I to III (primigravidae betw-en the 6th and 12th weeks of pregnancy), in the mean PGF2alpha dosages there were no significant differences between 6,84 and 6,27 mg. The mean abortion time was between 8 hr 32 min and 7 hr 43 min. In group IV ("problem cases" in the first and second trimester of pregnancy), the mean PGF2alpha dosage was 10,68 mg. The mean abortion time 12 hr 04 min. The total complication rate was at 2,2 per cent.

Abortion, Induced↗
PubMed1976

[New findings on human prolactin].

Since prolactin (HPRL) occurs as a separate pituitary hormone in man the paper will discuss results about the mechanisms involved regulation of HPRL secretion. A number of factors which lead to an increase in HPRL secretion are named. The clinical relevance of HPRL inhibiting substances as L-DOPA and 2-Br-alpha-ergocryptine is mentioned. The influence of HPRL in pregnancy and lactation period is described also the regulative effect of HPRL on hormone-dependent breast tumors.

Amenorrhea↗
PubMed1976

[Changes of the endometrium during oral hormonal contraception with ethinyl estradiol sulfonate and norethisterone acetate or d-noregestrel].

48 fertile women took in three weeks 1 mg ethinylestradiolsulfonate weekly and in the 4th week 10 mg norethisterone acetate, respectively d-norgestrel in different dosages (0,5 mgs, 1,0 mgs, 1,5 mgs or 3,0 mgs). On this 48 women 69 abrasiones were made between the first and 37th treatment cycles in order to estimate the endometrium. Ethinylestradiolsulfonate caused for the most part a proliferation of endometrium, which reached to a glandulare cystic hyperplastic endometrium. We did not observe a reduction of the endometrial respond to this depot-estrogen in dependence on the time of taking. Norethisterone acetate and d-norgestrel effected on a different proliferated endometrium a secretory transfer mation always.

Adolescent↗
PubMed1975

[Clomiphene--its use from stimulation test and for treatment of functional sterility].

There is reported on application of clomiphene (Clostilbegyt-EGYT Pharmaceutical Works, Budapest, Hungaria) in 17 patients for a clomiphene-stimulation-test and in 34 patients with functional sterility on 124 cycles. The dosage was between 50 to 150 mg p.d. for 5 to 7 days and was adapted individually. 12 patients responded to clomiphene-stimulation-test positively and in 4 ovarian hypoplasias and one Anorexia nervosa in acute phase, the clomiphene-stimulation-test was negatively. From the 34 patients with functional sterility 18 women were in 21 times gravid, 13 women could be delivered on term; in 8 cases it was an abortion. By reason of the findings after a clomiphene therapy a gravidity can be accepted, if the hyperthermic phase in the BBT existed for more than 25 days. For a repetition - treatment a dosage is recommended with 150 mg p.d. clomiphene for 7 days.

Adult↗