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Biomedical subjects

K Reed

Publications and source records attributed to K Reed.

At least 91 records · Page 5Linked to original sources

The association of Fanconi's anemia and squamous cell carcinoma.

Fanconi's anemia is a rare autosomal recessive disorder which manifests itself in early childhood, presenting as pancytopenia, pigmentation changes, skeletal deformities, small statures and chromosomal aberrations. Most patients ultimately die from sepsis as a result of their hematologic abnormalities, however, some patients live long enough to develop malignancies such as leukemia, hepatocellular carcinomas and squamous cell carcinoma. The association of Fanconi's anemia and squamous cell carcinoma is examined with a report of a patient with Fanconi's anemia and squamous cell carcinoma of the pyriform sinus and hypopharynx.

Adult↗

Epidemic viral keratoconjunctivitis diagnosis and management.

The author reports an epidemic of adeno- and enteroviral eye infections at an overseas military complex in the third quarter of 1981. A similar epidemic was reported by the Center for Disease Control, Atlanta, GA to also have occurred in Florida, Latin America, and North Carolina at approximately the same time. The differential diagnosis between epidemic keratoconjunctivitis, pharyngoconjunctival fever, acute hemorrhage conjunctivitis and Chlamydial infections is described. Epidemiology and management of these widely seen ocular infections are also discussed.

Adenoviridae Infections↗

Mania in Cushing's syndrome: case report.

A case is described of recurrent mania without depressive episodes in a patient subsequently diagnosed as having an ACTH-producing basophil adenoma. The difficulties involved in the clinical and laboratory diagnosis of Cushing's syndrome, and the ramifications of neuroendocrinopathies' ability to mimic symptoms of functional psychosis, are discussed.

Adenoma, Basophil↗

The value of computed tomography in the diagnosis and management of pediatric mediastinal abnormalities.

The utility of computed tomography (CT) in evaluation of mediastinal abnormalities was assessed in 23 pediatric patients. By comparison with standard chest radiography, CT provided additional diagnostic information in 82% of the patients. In 65%, the CT findings contributed to a change in clinical management. CT was most useful in documenting a benign process (near-water-density mass or a normal vascular or soft-tissue structure) and in demonstrating the full extent of a malignant tumor.

Adolescent↗

Amitriptyline versus placebo in postherpetic neuralgia.

To study the effects of amitriptyline in treating postherpetic neuralgia, 24 patients were randomly assigned to either drug or placebo in a double-blind crossover study. We found good to excellent pain relief in 16 of 24 patients (p less than or equal to 0.001). We did not find an antidepressant effect in most patients (p greater than 0.05). The median dose of amitriptyline was 75 mg. The median blood level was 65 ng per milliliter, and of nortriptyline 30 ng per milliliter. Good responses were maintained in 12 of 22 patients. Amitriptyline is useful in treating postherpetic neuralgia and may not act as an antidepressant.

Aged↗

Diffuse juvenile polyposis of the colon: a premalignant condition?

Juvenile polyps are a common cause of rectal bleeding in the pediatric age group. These polyps are usually solitary, but occasionally polyposis can be identified by barium-enema or colonoscopy examinations. The benign nature of a single polyp or even scattered polyposis in childhood has been supported by several authors. A case of diffuse juvenile polyposis of the colon with associated adenomatous polyps of the colon in a 17-year-old who presented with iron deficiency anemia and rectal prolapse is discussed. This combination of diffuse juvenile polyposis and adenomatous polyps is an uncommon entity which is left to represent a premalignant lesion that warrants appropriate therapy. A review of the literature concerning the cause, diagnosis, and treatment of juvenile polyps is also discussed.

Adolescent↗