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Biomedical subjects

K Reed

Publications and source records attributed to K Reed.

At least 73 records · Page 4Linked to original sources
PubMed1987

Plasma levels and effects of nortriptyline in geriatric depressed patients.

Pharmacokinetic, therapeutic effects, and side effects of nortriptyline were studied in geriatric depressed patients treated with a standard dose of 150 mg/day. Plasma levels and elimination half-life of nortriptyline were no different in geriatric patients than younger patients. The antidepressant therapeutic effects of nortriptyline appeared to be similar in geriatric patients as in younger depressed patients. Geriatric patients experienced few subjective side effects of nortriptyline. Overall, the drug produced no clinically significant changes in several parameters of the EKG, and no geriatric patient experienced tachycardia on nortriptyline. Nortriptyline did induce significant orthostatic hypotension in the systolic component, but not in the diastolic component. However, the orthostatic hypotension produced by nortriptyline was not greater in geriatric patients than in younger patients treated with the same dose.

Age Factors↗
PubMed1987

Consultation liaison.

Explore the source record for details and available documents.

Emergency Services, Psychiatric↗
PubMed1987

Factor VIII-associated antigen in human lymphatic endothelium.

Lymphatic vascular endothelium both on tissue section and in culture exhibits positivity for Factor VIII-associated antigen although staining is generally less intense and more spotty than in comparable blood vascular endothelium. Lymphatic endothelium also exhibits Weibel-Palade bodies. Neither marker, therefore, reliably distinguishes blood vascular endothelium from lymphatic endothelium.

Antigens↗
PubMed1987

Adrenoleukodystrophy: imaging with CT, MRI, and PET.

A patient with adrenoleukodystrophy (ALD) was tested with a series of CT scans, magnetic resonance imaging (MRI), and positron emission tomographic (PET) images. The computed tomographic (CT) scan revealed the classical pattern described in ALD but showed little relation to the clinical presentation and the evolution of the disease. The MRI showed a larger area of abnormality than the one detected with the CT scan and was more sensitive to progression of the disease process. The PET scan done for cerebral blood flow and glucose metabolism showed derangements on gray matter that were not detected with either of the previous tests.

Adrenoleukodystrophy↗
PubMed1986

Primary retroperitoneal sarcomas.

A retrospective analysis of 20 adult patients with primary retroperitoneal sarcomas demonstrated that most patients presented with pain and a palpable abdominal mass. Liposarcomas and leiomyosarcomas were the most common tumors. Seven of the 20 patients (35 percent) had complete tumor excision. Operative morbidity was 18 percent with no mortality. After complete resection, the 5 year survival rate was 43 percent. Thirteen patients underwent partial excision of tumor, with an operative morbidity rate of 29 percent and a mortality rate of 15 percent. No patient in our series lived more than 2 years after only partial excision. Anatomic restrictions to wide resection and local recurrence were the most important factors determining survival. Aggressive, complete surgical resection in treating primary retroperitoneal sarcomas is strongly recommended.

Adult↗
PubMed1986

Desipramine plasma concentration and therapeutic response in elderly depressives: a naturalistic pilot study.

This naturalistic pilot study of desipramine hydrochloride treatment in elderly DSM III diagnosed depressives demonstrated that therapeutic response was related to desipramine plasma levels and that a desipramine plasma concentration of 200 nmol/l significantly differentiated responders from non-responders. Plasma concentrations of 2-Hydroxydesipramine were not related to therapeutic response. This finding suggests that monitoring of desipramine plasma levels has utility in certain clinical situations. Further fixed dosage studies are necessary to confirm these initial results.

Aged↗
PubMed1986

Embryonic heart rates before the seventh week of pregnancy.

Previous studies of normal human embryonic heart rates showed an increase in the rates between the 7th and 9th gestational weeks; the rates gradually declined thereafter until the 15th week. The present study added new information about embryonic heart rates before the seventh week. The heart rates are slower than those reported to occur after the seventh week. These observations are connected with morphologic and physiologic changes during this period of embryonic life.

Female↗
PubMed1985

Syndrome of camptodactyly, ankyloses, facial anomalies, and pulmonary hypoplasia (Pena-Shokeir syndrome): obstetric and ultrasound aspects.

Two siblings with Pena-Shokeir syndrome are described. This syndrome consists of polyhydramnios, intrauterine growth retardation, short umbilical cord, perinatal death, facial abnormalities, limb abnormalities including arthrogryposis, and lethal pulmonary hypoplasia. The mode of inheritance is most likely autosomal recessive. Prenatal diagnosis was made in the second pregnancy with ultrasound performed at 26 weeks' gestation. The roles of fetal akinesia and fetal apnea in the production of the various manifestations of the syndrome are detailed, and the possibility of early prenatal diagnosis is considered.

Abnormalities, Multiple↗
PubMed1985

Acute cholecystitis associated with hepatic arterial infusion of floxuridine.

In a 1 year period, 13 patients underwent pump implantation for liver metastasis from a primary colorectal tumor. The gallbladders were not removed at the time of pump implantation in the initial six patients. In these patients, chemotherapy consisted of floxuridine given every 2 weeks followed by a 2 week rest period and cisplatin over 1 hour by way of the side portal on day 8 of the cycle. The treatment was repeated every 28 days. All patients whose gallbladders were not removed at the time of pump implantation required reoperation for acute or chronic acalculous cholecystitis from 1 to 9 months (mean 5.4 months) after pump implantation. At operation, all patients were found to have various degrees of inflammation and fibrosis. In one patient, significant sclerosing cholangitis was documented that involved the entire intrahepatic ductal system and hepatic duct bifurcation. Cholecystectomy and operative cholangiography are recommended in all patients who undergo pump implantation for metastatic disease to the liver.

Acute Disease↗
PubMed1985

A totally implantable venous access system for long-term chemotherapy in children.

A totally implantable venous access system consisting of a subcutaneously placed stainless steel portal with a silicone diaphragm attached to a Silastic elastomer central venous catheter was inserted in 39 children with poor venous access. The devices were utilized for blood drawing and the administration of antineoplastic drugs, parenteral nutritional fluids, antibiotics, and blood products. Cumulative duration of access was 6,724 days (range 5-491, median 172 days). Major complications necessitating removal of the device included catheter sepsis or pocket abscess (7%), catheter clot not responsive to enzyme declotting (5%), and catheter occlusion by too tight a ligature (2%). The system provided easy venous access and permitted full physical activity.

Anti-Bacterial Agents↗
PubMed1985

Reliability of rapid clinical staging of all night sleep EEG.

The recording of all night sleep EEGs on a portable cassette recorder, and the rapid visual staging of the sleep records at 20 times real time, represent innovations in sleep research methodology. The reliability of sleep stager percentages obtained in this way is examined in this article. In the first of two studies, all night sleep records for six individuals were each staged twice by each of two qualified electroencephalographers. Inter-rater and intra-rater reliability assessed by intraclass correlation methods was modest, requiring the averaging of results from two judges to reach acceptable levels. Following consistency training, the two electroencephalographers staged all night sleep records for six additional subjects. Acceptable reliability was achieved in measurement of stages 2, 3, 4 and REM, although difficulty in reliably distinguishing stage 1 from the awake stage persisted. On the basis of these results, rapidly paced visual interpretation of sleep records at 20 times real time is recommended as a feasible way of meeting demands imposed by innovations in the technology of recording sleep EEGs.

Electroencephalography↗
PubMed1984

Quantitative relationships between structure and pharmacokinetic parameters using molecular connectivity chi indices I: Substituted 2-sulfapyridines.

Quantitative relationships between the structure and pharmacokinetic parameters of several compounds have been derived using the molecular connectivity approach. The correlation coefficients of equations obtained using the Chi indices (chi) as predictor parameters were compared favorably with those obtained by the linear free energy approach, where physicochemical parameters have been used as predictor variables. High correlation coefficients (r) for the first-order elimination rate constant (r = 0.86), total body clearance (r = 0.89), and protein binding association constant (r = 0.78) for substituted 2-sulfapyridines were obtained. However, including the pKa (indicative of electronic effects) of the compounds within the equation as a predictor variable caused an increase in the correlation coefficients.

Chemical Phenomena↗
PubMed1984

Renal toxicity of mitomycin-C.

The clinical spectrum and the pathological findings of renal toxicity in four patients treated with mitomycin-C are described. Our experience and evidence in the literature indicates that the renal impairment appears to be total-dose-related, with most patients developing renal symptoms after receiving at least 60 mg of mitomycin-C. The renal morphologic changes reveal a glomerular and vascular process similar to that seen in a number of clinical situations associated with the hematologic findings of microangiopathic hemolytic anemia. In patients with malignant disease, it may be that the use of mitomycin-C either alone or in combination with other drugs causes endothelial vascular damage with resultant activation of the coagulation system. There is evidence that early detection of the renal impairment and withdrawal of mitomycin-C might halt further progression of renal failure.

Adult↗
PubMed1984

PPNG conjunctivitis.

The treatment regimen for penicillin sensitive gonococcal conjunctivitis in an adult normally includes parenteral penicillin, frequent ocular irrigation, and topical ophthalmic gentamicin or tetracycline ointment. However, if a conjunctivitis is caused by a beta-lactamase producing microbe such as PPNG, then different antibiotics are required: e.g., spectinomycin or cefoxitin parenterally and topical chloramphenicol. Also, whereas urethritis is frequently treated with singular injections of penicillin or spectinomycin HCI (Trobicin), cases of PPNG ocular infections require a much longer course of treatment often involving seven days of intramuscular or intravenous antibiotics.

Adult↗
PubMed1984

Targeting therapeutic plasma levels of nortriptyline from test dose plasma concentrations.

Computer programs, based on first order pharmacokinetic equations, were developed to predict steady state plasma levels and required daily maintenance doses of nortriptyline from plasma concentrations 24 hours after a test dose. These predictions are compared to clinical findings for geriatric and nongeriatric patients with a variety of accompanying medical disorders and concurrent medications.

Computers↗