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Biomedical subjects

K Reed

Publications and source records attributed to K Reed.

At least 55 records · Page 3Linked to original sources
PubMed1991

The effect of glutathione monoethyl ester on the potentiation of the acute toxicity of methyl parathion, methyl paraoxon or fenitrothion by diethyl maleate in the mouse.

Depletion of hepatic glutathione in the mouse by pretreatment with diethyl maleate (DEM) is known to potentiate the acute toxicities of many dimethyl-substituted organothiophosphate insecticides. However, certain studies have raised doubts regarding the participation of glutathione in the detoxification of methyl parathion in the mouse, and hence the putative mechanism of action of DEM-induced potentiation of this insecticide. The present study evaluates the hypothesis that DEM potentiates the acute toxicities of methyl parathion, methyl paraoxon, and fenitrothion by a mechanism other than glutathione depletion. One hour following pretreatment of mice with DEM (0.75 ml/kg i.p.), glutathione was markedly depleted and the acute toxicities of methyl parathion, methyl paraoxon and fenitrothion were potentiated. Administration of glutathione monoethyl ester (20 mmol/kg p.o.) to DEM-pretreated mice attenuated DEM-depletion of hepatic glutathione, or maintained glutathione at or above control levels. However, glutathione monoethyl ester did not alter the DEM-induced potentiation of the lethality of these insecticides. Furthermore, administration of glutathione monoethyl ester to naive mice increased hepatic glutathione levels, but did not affect the percentage of animals succumbing to a challenge dose of methyl parathion, methyl paraoxon, or fenitrothion. These data indicate that DEM potentiates the toxicity of methyl parathion, methyl paraoxon or fenitrothion by a mechanism unrelated to hepatic glutathione content.

Animals↗
PubMed1991

A comparison of adinazolam and desipramine in the treatment of major depression.

Thirty-one patients with a DSM-III (R) diagnosis of Major Depression received adinazolam (n = 16) or desipramine (n = 15) during a 6 week double-blind randomized controlled trial. Both groups showed a significant decline in Hamilton Rating Scale for Depression scores (21.8 +/- 4.5 to 10.7 +/- 8.5 for adinazolam and 23.5 +/- 5.5 to 12.9 +/- 8.6) for desipramine. Melancholic and anxiety symptoms were reduced equally by both drugs. Initial sedation was the most common side-effect with adinazolam. Plasma levels of desipramine and hydroxy-desipramine correlated highly with oral dose after 3 weeks of treatment.

Adult↗
PubMed1991

Measles epidemic: impact on pediatric oncology patients.

Measles, a preventable disease, is again epidemic in the United States and is a threat to the immunocompromised pediatric oncology patient. In response to this latest epidemic, the Immunization Practices Advisory Committee has revised its recommendations for controlling an outbreak and has changed childhood immunization to a two-dose schedule. Full understanding of measles management is needed to effectively protect the pediatric oncology patient during the current epidemic. This article reviews the epidemiology, clinical presentation and management of measles, including recommendations for vaccinations, exposures, isolation, and patient and family education.

Child↗
PubMed1990

Influence of age and parity on the emotional care given to women experiencing miscarriages.

Obstetrical nurses (N = 309) participated in a study of the hypothetical influence of patients' age and parity status on nurses' emotional care for women who had experienced miscarriage. Vignettes in which age and parity were varied were mailed to the sample along with a questionnaire. After factor analysis, three measures of emotional care were used as the dependent variables: emotional seriousness, priority of care, and emotional support. Analysis of variance showed that the parity status of the woman was a significant variable in the nurses' perceptions of emotional seriousness and priority of care, but did not affect the nurses' perceptions of the need for emotional support. Age was not a significant variable in the three measures of emotional care.

Abortion, Spontaneous↗
PubMed1990

Prevalence of neuroleptic-induced dystonia in mania and schizophrenia.

In a prospective study of 41 acutely psychotic patients, neuroleptic-induced dystonic reactions occurred in 62.5% of the manic patients (10 of 16) and 66.7% of the schizophrenic patients (10 of 15), a nonsignificant difference. These findings contradict a recent report suggesting a higher risk for this side effect in mania.

Acute Disease↗
PubMed1989

Leiomyomas of the gastrointestinal tract.

Sixteen patients with leiomyoma of the gastrointestinal tract underwent operation and removal of their tumor during a four- and one-half-year period from January 1980 to July 1984. There were three esophageal, five gastric, two small bowel, four colon, and two anorectal leiomyomas. The majority of gastric leiomyomas presented with bleeding, as did half of the small bowel and colon cases. All were treated by excision without mortality. The various clinical presentations, evaluations, and choice of operative approach for this uncommon tumor are discussed.

Adult↗
PubMed1989

A prospective evaluation of the Port-A-Cath implantable venous access system in chronically ill adults and children.

Totally implantable venous access systems are presently widely used, but large-scale, prolonged studies are lacking in evaluating adequately these systems. We prospectively evaluated 198 systems in 191 patients (ages from two months to 80 years) during a three year period, with a median follow-up time of 330 days (a range of two to 1,088 days). Withdrawal of blood was consistently successful in 91 per cent of the systems. Complication rates for infection and thrombosis were 0.04 and 0.03 per 100 days of catheterization, respectively. No episodes of migration of the catheter or embolization were noted. This was thought to be the result of the placement of all catheters by a cutdown technique rather than percutaneously. Five systems were removed because of thrombosis and 22, because of infection. Implantable venous access devices are reliable and have a low complication rate in adult and pediatric patients who require repetitive venous access.

Adolescent↗
PubMed1988

Changes in plasma catecholamines and plasma renin activity during hypotension in conscious rats with lesions of the nucleus tractus solitarii.

The purpose of the present study was to examine the effects of lesions of the nucleus tractus solitarii on the reflex control of sympathetic activity and renin release in the conscious rat. Two doses of the arteriolar vasodilator hydralazine (0.3 and 1 mg/kg, i.v.) were used to activate reflexively the sympathetic nervous system in nucleus tractus solitarii lesion and control rats. Administration of 1 mg/kg of hydralazine to the control rats caused mean arterial pressure to fall from 120 +/- 2 mm Hg to 84 +/- 2 mm Hg and elicited an 11.2-fold increase in plasma renin activity and a 2.7-fold increase in plasma norepinephrine concentration. Administration of 0.3 mg/kg of hydralazine caused the arterial pressure of the lesion group to fall from 118 +/- 3 mm Hg to a comparable value of 85 +/- 4 mmg Hg, but plasma renin activity and plasma norepinephrine concentration did not rise significantly. However, administration of 1 mg/kg of hydralazine to the lesion group caused arterial pressure to fall from 128 +/- 6 mm Hg to 64 +/- 2 mm Hg, in association with a 12.4-fold increase in plasma renin activity and a 1.6-fold elevation in plasma norepinephrine concentration. Atenolol, a beta 1-adrenoceptor antagonist, blocked 70% of the rise in plasma renin activity caused by 1 mg/kg of hydralazine in both groups of rats. In addition, prior renal denervation also markedly attenuated the rise in plasma renin activity caused by hydralazine in the lesion group. Finally, electrical stimulation of the vagus nerves, which caused a large vasodepressor response in the control group, failed to lower the arterial pressure of the lesion group. Based on these observations, we conclude that in the conscious rat (1) nucleus tractus solitarii lesions eliminate the arterial baroreflexes as well as the cardiopulmonary baroreflex, and (2) severe hypotension induces sympathetically mediated renin release in the apparent absence of arterial and cardiopulmonary baroreflex function.

Animals↗
PubMed1988

Role of radionuclide imaging in the evaluation of wrist pain.

The cause of hand and wrist pain can be difficult to determine, especially when standard radiographs are normal or show only nonspecific changes. This study reports the effectiveness of radionuclide imaging in the evaluation of patients with hand and wrist pain of uncertain cause. Eighty-eight patients with hand and wrist pain and initially normal standard radiographs were evaluated prospectively by additional radiographic methods including the following: routine tomography, wrist arthrography, computerized tomography, or magnetic resonance imaging. Each patient also had bone scintigraphy. The diagnosis established by clinical assessment and by other imaging methods was then compared with the scintigraphic findings. The presence or absence of focal scintigraphic abnormalities correlated with the presence or absence of focal pathology definable by the conventional methods in 88% of patients. As expected, scintigraphy was chiefly of value in defining the locus of an injury or other process in the wrist, rather than the nature of an abnormality. The scintigrams were abnormal in 95% of cases involving complete intrinsic ligament ruptures and fractures and were normal in 96% of patients with no definable injury. Scintigraphic findings correlated poorly with partial intrinsic ligament injuries and in cases of synovitis. Radionuclide imaging is a sensitive means of detecting focal lesions in patients with hand and wrist pain of unknown cause.

Adult↗
PubMed1988

Rapid, inexpensive confirmation of chlamydial infection.

This article will hopefully make all optometrists aware of a rapid, direct method for confirming a diagnosis of chlamydial (inclusion) conjunctivitis. The Micro-Trak test from Syva is inexpensive, highly specific, and very sensitive for all human serovars of Chlamydia trachomatis. The current regimens for chlamydial conjunctivitis are also described.

Conjunctivitis, Inclusion↗
PubMed1987

PvO2 changes in cutaneous veins during regression of spinal anaesthesia.

Following transurethral resection of the prostate under spinal anaesthesia, 26 patients were divided into two groups according to the sensory levels measured in the recovery room: Group A: 20 patients with sensory level T10 or above, and Group B: six patients with sensory level T11 or T12. Through an intravenous catheter placed preoperatively in a superficial vein of the foot, serial blood samples were drawn to measure the PvO2. In Group A, the PvO2 increased significantly after spinal anaesthesia compared with preoperative control values, then decreased when the sensory level receded to T11 or T12. In Group B, the changes in PvO2 from control to postspinal and to motor recovery were not significant. The authors postulate that sympathetic denervation induced by spinal anaesthesia increases the PvO2 by the opening of arteriovenous anastomoses in the cutaneous circulation, and the PvO2 decreases with sympathetic recovery. These findings confirm that significant sympathetic denervation of the lower limbs can be expected at a sensory level of T10 or above, and sympathetic recovery begins when the sensory level recedes below T10.

Aged↗
PubMed1987

Doppler echocardiographic observations of pulmonary and transvalvular velocity changes after birth and during the early neonatal period.

To evaluate the qualitative and quantitative changes in Doppler velocities in the normal fetus and newborn, 61 echo Doppler studies were performed in 18 neonates, nine of whom were also studied as fetuses. Four studies were inadequate in fetuses (one pulmonary artery, two mitral, and one tricuspid) and some post natal studies were inadequate due to inability to separate atrioventricular valve E and A velocity component waveforms (one tricuspid, three mitral). Heart rates for fetuses and newborns more than 24 hours of age and less than 24 hours of age were similar. Pulmonary artery diastolic velocities consistent with patent ductus arteriosus were present in 11 of 12 examinations at less than 6 hours of age, in 5 of 13 examined at 6 to 24 hours of age, and in 2 of 27 examined after 24 hours of age. Pulmonary artery times to peak velocity were similar in fetuses, m = 46, SD = 3 msec, and in neonates less than 6 hours of age, m = 51, SD = 13 msec, but lengthened significantly, p less than 0.05, at 6 to 24 hours (m = 69, SD = 14 msec). These changes are probably due to the dramatic changes in pulmonary vascular pressure that occur after birth. Data from 6 to 24 hours and greater than 24 hours (m = 78, SD = 13 msec) were similar. Significant differences existed for transmitral valve E/A ratios, which increased from m = 0.85 in utero to m = 1.17 (p less than 0.05) after birth, with no significant change thereafter.(ABSTRACT TRUNCATED AT 250 WORDS)

Blood Circulation↗