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Biomedical subjects

K Ohara

Publications and source records attributed to K Ohara.

At least 325 records · Page 18Linked to original sources
PubMed1987

[Clinical observations on cefuzonam in pediatrics].

Cefuzonam (L-105, CZON) was given intravenously to 20 pediatric patients with the following acute bacterial infections: 13 of bronchopneumonia and 1 each of tonsillitis, purulent cervical lymphadenitis and acute tonsillitis, laryngitis, bronchitis, pyothorax, purulent meningitis complicated with septic arthritis, and urinary tract infection. Good clinical responses were obtained in all of the 20 patients and bacterial eradication of all 16 strains. No side effect was observed except 3 cases of slight elevation of transaminase, and 1 case each of soft stool and eosinophilia. From the above clinical results, it appears that CZON is a useful antibiotic for the treatment of pediatric patients with various kinds of bacterial infections.

Acute Disease↗
PubMed1987

[The integrated score of prognostic factors with regard to the recurrence of cervical carcinoma].

Eighty-nine patients with carcinoma of the cervix received radical radiation therapy from May 1981 through 1983 at the hospital of the National Institute of Radiological Sciences. After a 2 to 4 year follow-up, primary cancer was found to be controlled in 59 patients, a recurrence was noted in 16 patients but 12 patients had died without precise information concerning recurrence. We examined the correlation between recurrence and seven prognostic factors. Among these factors, the tumor volume, age, and the red blood corpuscle sedimentation rate showed a relatively strong correlation. A multivariable analysis (quantification methods II) was undertaken in order to integrate these prognostic factors and the score that was calculated from this analysis showed a strong correlation to local control. We believe that this score can be used for predicting recurrences and can be applied to the selection of patients for new treatments like hyperthermia or high LET irradiation.

Adenocarcinoma↗
PubMed1986

Systemic plasmacytosis. A syndrome of peculiar multiple skin eruptions, generalized lymphadenopathy, and polyclonal hypergammaglobulinemia.

A description is given of two patients with peculiar multiple skin eruptions, asymptomatic generalized lymphadenopathy, and polyclonal hypergammaglobulinemia. Both patients were admitted to our hospital for further evaluation of an increased erythrocyte sedimentation rate and hypergammaglobulinemia discovered during routine medical examinations. Despite various investigations, the underlying disease causing the hypergammaglobulinemia was not found. Histologic examination disclosed dense perivascular infiltration of plasma cells in the dermis. In the lymph nodes, considerable plasma cell infiltration was found from the cortex to the medulla. These plasma cells were mature and showed no cellular atypism. The association of peculiar multiple skin eruptions, lymphadenopathy, and polyclonal hypergammaglobulinemia, which we have called "systemic plasmacytosis," signifies a new syndrome that can be differentiated from diseases reported previously.

Adult↗
PubMed1986

Treatment of leukemia and myelodysplastic syndromes with orally administered N4-palmitoyl-1-beta-D-arabinofuranosylcytosine.

N4-Palmitoyl-1-beta-D-arabinofuranosylcytosine (PLAC) was administered PO to 76 patients with acute leukemia, myelodysplastic syndromes (MDSs), and myeloproliferative disorders (MPDs). Of 20 patients with acute myelogenous leukemia, 2 achieved complete remission, and the only patient with acute lymphoblastic leukemia achieved partial remission. Remission was reached with PLAC 100-300 mg/day 25-66 days after the start of therapy. Among 22 patients with MDS, 1 patient achieved a good response and 8 achieved partial response. Responses were reached with PLAC 50-200 mg/day 7-153 days (median, 33 days) after the start of therapy. Improvement of polycythemia was observed in all 5 patients with polycythemia vera, and reduction of thrombocytosis was observed in 5 out of 6 patients with essential thrombocythemia and myelofibrosis. An antileukemia effect was noted in 1 of 5 with chronic myelogenous leukemia. Major side effects were gastrointestinal toxicities and myelosuppression. In spite of the disadvantages, such as unpredictable absorption and a lower response rate to acute leukemia compared with its parent compound, this antileukemia Ara-C analogue that is administrable PO will be useful in the treatment of MDSs and MPDs, which do not necessarily require admission to hospital, and in the treatment of acute leukemia of the aged, a condition for which intensive chemotherapy is not appropriate.

Administration, Oral↗
PubMed1986

Lectin-binding sites in eccrine sweat gland tumours.

Lectin-binding sites in sections of formalin-fixed, paraffin-embedded eccrine sweat gland tumours were investigated using fluorescein isothiocyanate (FITC) conjugated peanut agglutinin (PNA), FITC conjugated Ricinus communis 1 agglutinin (RCA-1) and FITC conjugated wheat germ agglutinin (WGA). In 22 benign eccrine sweat gland tumours, lectin-binding sites were noted primarily on the cell surface, and in the secretions. In five malignant sweat gland tumours, all showed cytoplasmic lectin-binding sites in variable proportions of malignant cells in addition to cell surface staining. These results indicate that cytoplasmic lectin-binding sites may be a useful marker of neoplastic transformation of eccrine sweat gland tumours.

Cell Membrane↗
PubMed1986

Metastasizing atrial myxoma: a case with multiple subcutaneous tumours.

We report a case with rapidly growing subcutaneous and intra-muscular tumours that were identical histopathologically to a pre-existing left atrial myxoma. No invasion of visceral organs or skeleton was found. This is a very rare case of metastasizing myxoma with wide dissemination and rapid metastastic growth, despite the benign appearance of the original tumour.

Adult↗
PubMed1986

Digital radiographic imaging system with multiple-slit scanning x-ray beam: preliminary report.

A digital imaging system that employs a novel scanning x-ray tube, a multiple-slit assembly (MSA), and an image intensifier (II)-TV digital system is described. Use of the MSA can increase x-ray utilization by a factor of 100 over that obtained with single-slit systems. Scatter and veiling glare can be reduced substantially by synthesizing the final image from a number of multiple-slit images, resulting in improvement in contrast sensitivity. An experimental prototype system consisted of a conventional x-ray tube and an II-TV digital system used in conjunction with mechanical scanning of the MSA. Attenuation curves measured with an aluminum stepwedge showed that scatter and veiling glare were eliminated by this approach. Reconstructed images of phantoms were superior to images obtained with conventional wide-beam exposure. Physical parameters related to design of the scanning x-ray tube and a digital system for acquiring images of the chest are discussed.

Humans↗
PubMed1986

Current status and problems in long-term management of patients undergoing coronary artery bypass surgery in Japan.

We studied 272 patients undergoing coronary artery bypass surgery (CABS) to clarify the long-term effects of CABS and to identify problems in long-term management. Data on patients' pre and postoperative medical status were obtained from hospital files. A specially designed questionnaire was sent to all patients to assess residual angina, return to work, non-work physical activity and improvement in the quality of life after a mean follow-up of 29 months. Multivessel disease accounted for 89% of all patients and complete revascularization was achieved in 55%. A total of 131 events of complications associated with CABS occurred in 112 patients; post-transfusion hepatitis was the most frequent complication (26%). Graft patency rate was 89% at the time of hospital discharge. Bypass grafts were patent in 95% of 243 grafts which were restudied at a mean period of 19 months after the first study. There was no significant difference in the patency rate between patients with well controlled, poorly controlled or discontinued anticoagulant therapy. Patients who were relieved from angina, returned to gainful work and had no limitation in non-work physical activity accounted for 74%, 79% and 73%, respectively. By subjective assessment, the quality of life improved in 76% of all patients. Objectively, contributing factors preventing improvement in the life quality were residual angina and post-transfusion hepatitis. There were 13 patients who were readmitted because of cardiac events. Three patients died from these events including two from sudden death during follow-up. We conclude that the beneficial effects of CABS are actually attainable.(ABSTRACT TRUNCATED AT 250 WORDS)

Activities of Daily Living↗