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Biomedical subjects

K Murayama

Publications and source records attributed to K Murayama.

At least 163 records · Page 9Linked to original sources
PubMed1988

[A case of neurogenic bladder complicated by an acute rash syndrome (measles?)].

A 24-year-old female patient was was admitted because of urinary retention, four days after the development of rash with fever to be diagnosed as measles by a doctor. Neurological examinations showed hyperesthesia in lower thoracic regions and increased deep tendon reflexes in lower extremities. Cystometric findings revealed an areflexic bladder with normal sensation. Cerebrospinal fluid examination showed mononuclear pleocytosis and slightly elevated levels of protein. There was no significant increase in serum measles antibody titer. She regained normal voiding by conservative treatment with an indwelling catheter for four days. The bladder motor paralysis was probably due to non-transverse myelitis in sacral spinal region. Neurological complications of measles are briefly discussed.

Adult↗
PubMed1988

[Transurethral resection of bladder neck in female patients with neurogenic bladder].

Transurethral resection of the bladder neck was performed in 6 female patients with neurogenic bladders who presented with a large volume of residual urine and bladder neck obstruction on voiding cystourethrography without detrusor hyperreflexia on cystometry. In 4 of the patients, transurethral sphincterotomy was performed concomitantly. Five of the patients demonstrated significant improvement in bladder emptying and 4 did not need self-catheterization. No complications of the operation were observed.

Adult↗
PubMed1987

Fetal pulmonary hypoplasia with hydrothorax.

Described is a case of fetal congenital malformation with hydrothorax, for which left pulmonary hypoplasia was initially presumed by ultrasonography and for which hypoplasia was diagnosed postnatally only in the left lower pulmonary lobe by a pulmonary technetium Tc-99m scintigram. The pathogenesis of this disease is discussed.

Adult↗
PubMed1987

Diverse effects of insulin-induced hyperpolarization on 3-O-methyl-D-glucose (3-O-MG) transport in frog skeletal muscles.

It has been suggested that the insulin-induced hyperpolarization might be a mediator of the stimulatory action of insulin on glucose transport. The purpose of the present study was to investigate the relationship between the insulin-induced hyperpolarization and the stimulatory action of insulin on glucose transport in skeletal muscle. Satorius muscles dissected from bullfrogs (Rana catesbeiana) were used. Insulin induced a hyperpolarization of the membrane and an increase in the 3-O-Methyl-D-glucose (3-O-MG) uptake and extrusion. In the presence of valinomycin, insulin had no significant effect on the membrane potential. Insulin still had the stimulatory action on both the 3-O-MG uptake and extrusion even in the presence of valinomycin, under whose condition insulin had no significant effect on the membrane potential. The magnitude of the stimulatory action of insulin on the 3-O-MG uptake in the presence of valinomycin was smaller than that in the absence of valinomycin. The magnitude of the stimulatory action of insulin on the 3-O-MG extrusion was, on the contrary, larger than that in the absence of valinomycin. The abolishment of the insulin-induced hyperpolarization decreased the 3-O-MG uptake and increased the 3-O-MG extrusion. The observation in the present study concludes that insulin has two different actions on glucose transport. One of them is developed through the insulin-induced hyperpolarization, which increases the 3-O-MG uptake and decreases the 3-O-MG extrusion. The other action is irrelevant of the insulin-induced hyperpolarization and stimulates both the 3-O-MG uptake and extrusion.

3-O-Methylglucose↗
PubMed1987

[A urodynamic study of detrusor hyperreflexia in benign prostatic hypertrophy].

Urodynamic study was performed on 48 patients with benign prostatic hypertrophy. Twenty six of the patients had detrusor hyperreflexia. The mean age of the patients with detrusor hyperreflexia was higher, the mean value of urinary frequency was greater, the mean value of bladder capacity was smaller and the mean value of maximum voiding pressure was higher than those of patients without detrusor hyperreflexia. Small bladder capacity and high voiding pressure of patients with detrusor hyperreflexia were improved 3 months postoperatively. Eight of the 14 patients with detrusor hyperreflexia had normal bladder function, but detrusor hyperreflexia of the resting 6 patients was persisting. The mean value of posterior urethral length on the urethral pressure profile of patients with persisting detrusor hyperreflexia was shorter than that of patients with improved detrusor hyperreflexia. This suggested that the shorter length of posterior urethra may be a causative factor for persisting detrusor hyperreflexia.

Aged↗
PubMed1987

[A case of xanthogranulomatous pyelonephritis probably derived from a renal injury].

A 56-year-old women was admitted for examination of glycosuria. She had had a blunt trauma onto the left abdomen 2 years ago that could have caused renal injury. Incidentally a left renal mass was detected by ultrasonography as a low echogenic mass. CT scan revealed a 2.5 X 2.5 cm mass with lower density than the kidney. IVP and renal angiography showed no abnormal findings. Under the diagnosis of renal tumor, left nephrectomy was performed. A 2 X 2 cm butter-yellow tumor, was seen in the renal parenchyma including the renal capsule of the upper and lateral part of the kidney. The renal pelvis was normal and there were no suppurative lesions in the kidney. Histopathological diagnosis was xanthogranuloma of the kidney partly containing a subcapsular hematoma. The previous blunt trauma, presence of hematoma and no evidence of suppurative lesions suggested that the etiology of xanthogranuloma in this case was related to renal injury.

Female↗
PubMed1986

Immobilization of uricase on protamine bound to glass beads and its application to determination of uric acid.

Uricase was found to be stabilized by protamine from salmon testis. Protamine was then bound to controlled-pore glass beads aminohexyl CPG 500 using glutaraldehyde. Microbial uricase was readily immobilized on the protamine bound to glass beads. The immobilized uricase proved to be stable even at 70 degrees C, whereas free uricase was inactivated at 45 degrees C and showed activity over a broader pH range than free uricase. Automated analysis of uric acid was facilitated using the immobilized uricase. The standard curve for uric acid was linear in the range of 2 to 10 micrograms/sample and passed through the origin. This automated procedure was also applicable to the determination of uric acid in human serum. Protamine bound to glass beads is expected to be useful for the simple immobilization and stabilization of enzymes.

Animals↗
PubMed1986

Qualitative differences in position of sialylation and surface expression of glycolipids between murine lymphomas with low metastatic (Eb) and high metastatic (ESb) potentials and isolation of a novel disialoganglioside (GD1 alpha) from Eb cells.

Glycolipids of murine lymphoma cell lines with low metastatic (Eb) and high metastatic (ESb) potentials have been investigated. The Eb cell line was characterized by a high quantity of gangliotriaosylceramide (Gg3), gangliotetraosylceramide (Gg4), GM1b, and a new type of disialoganglioside, termed GD1 alpha. In contrast, the high metastatic ESb cell line was characterized by the absence of these glycolipids and instead by the presence of GM3, GM2, GM1a, GD1a, and GD1b gangliosides. A clear cell surface reactivity with monoclonal antibody anti-Gg3 (2D4) was observed only in Eb cells. Thus, Eb cells are distinct from ESb cells in their ability to add the GalNAc residue to LacCer, supplying Gg3 for synthesis of a series of glycolipids via an asialogangliotetraosyl pathway, while ESb cells are capable of synthesizing GM3, which initiates synthesis of ganglio-series gangliosides GM2, GM1a, GD1a, and GD1b. While disialogangliosides of ESb cells were identified as GD1a and GD1b, a disialoganglioside isolated from Eb cells was characterized as having a novel structure (referred to as GD1 alpha) as follows: (formula; see text) Thus, Eb and ESb cells are clearly different in their qualitative sialylation patterns, i.e., the position of sialic acid residues. Cell surface labeling with galactose-oxidase/NaB[3H]4 revealed a high exposure of Gg3 and Gg4 at the Eb cell surface, while both labels were absent in ESb cells. In contrast, ESb cells showed a substantial label at GM1a, which was greatly enhanced after sialidase treatment.

Animals↗
PubMed1986

[A clinical study on the R-R interval of ECG in diabetic neurogenic bladder].

Urodynamic investigations and the measurement of the R-R interval on ECG have been applied to assess the extent of autonomic and peripheral neuropathy in 12 patients with diabetes mellitus. Objective evidence of neuropathic bladder dysfunction was detected in 6 patients (50%) and these cases were included under 2% of the coefficient of R-R interval variation. The commonest abnormality was hypotonic, large bladder and marked residual urine, which was usually asymptomatic. It is concluded that in diabetic patients this simple autonomic function test is a good guide to vesical function.

Adult↗
PubMed1986

[A clinical study on the R-R interval on ECG in urethral syndrome].

We reviewed 41 patients who were evaluated for the urethral syndrome. Evaluation included urinalysis, cystoscopy and the measurement of the R-R interval on ECG in all cases. The coefficient variation of R-R interval in urethral syndrome was significantly lower (p less than 0.001) than that of the healthy individuals. Treatment by mecobalamin showed that 4 of the 6 patients benefitted considerably.

Adult↗
PubMed1986

[Two cases of hyperfunctioning parathyroid cyst].

Two cases of parathyroid cyst were experienced. Both cases presented clinical data and symptoms of hyperparathyroidism. Microscopically, one had a thin fibrous wall containing parathyroid adenomatous tissue in the inner surface and the other showed cyst formation without any histological evidence of adenoma or hyperplasia. Most parathyroid cysts are non-functioning. In occasional cases, the cyst may contain a hyperfunctioning adenoma. The hyperfunctioning parathyroid cysts with normal parathyroid tissue are discussed.

Aged↗
PubMed1985

Pattern electroretinograms recorded with a skin electrode in pigmentary retinal degeneration.

In 24 patients suffering from pigmentary retinal degeneration the electroretinograms to pattern stimulation (PERG) were recorded with a silver-cup electrode placed on the center of the lower eyelid skin referred to an electrode on the earlobe. The results were compared with the responses to flash stimulation (FERG) and pattern visual evoked cortical potentials. None of patients showed normal FERGs. Nineteen of 48 eyes showed subnormal FERGs. The PERG was recorded from those 19 eyes. In the remaining 29 eyes with flat FERG, 8 eyes showed clear PERGs. The peak latency of the first positive component of PERGs was found to be prolonged in these patients. PERGs seemed to be recordable in the patients whose visual acuity and central visual field were relatively well preserved.

Adolescent↗