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K Lee

Publications and source records attributed to K Lee.

At least 847 records · Page 47Linked to original sources
PubMed1985

[Systemic chemotherapy with super-high dose cisplatin and sodium thiosulfate (STS) rescue in mice].

We have devised a new systemic chemotherapy using cisplatin (DDP) with sodium thiosulfate (STS) rescue; basically, STS was given repeatedly 6 hours after DDP administration combined with metoclopramide. The effect of STS-rescue on the antitumor activity of DDP was studied using a BALB/c syngeneic fibrosarcoma (KKN-1). A graded dose of DDP was given i.p. with or without STS-rescue and its effects were evaluated according to N. C. I. protocol. A DDP dose-related antitumor activity was observed and the minimal effective doses were calculated as 8.2 and 9.8 mg/kg for groups treated with DDP alone and with STS-rescue, respectively. When STS-rescue was combined, however, super-high doses of DDP (9-16.5mg/kg) could be administered and this resulted in a 52% increase in chemotherapy index.

Animals↗
PubMed1984

Infection of a Chlorella-like alga with the virus, PBCV-1: ultrastructural studies.

Ultrastructural studies revealed that the virus, PBCV-1, adsorbs to the surface of the Chlorella-like green alga NC64A and enzymatically digests a portion of the host cell wall. The viral DNA is then released into the interior of the cell leaving an empty capsid on the surface. Thus uncoating of the viral genome occurs at the surface of its host. PBCV-1 also adsorbs to and digests the host wall of either heat-killed, methanol-extracted, or purified cell wall fragments.

Chlorella↗
PubMed1984

Assessment of regional left ventricular function using gated radionuclide angiography.

A simple method for the assessment of regional left ventricular (LV) function using gated radionuclide angiography is described. The method divides the LV region of interest in the left anterior oblique view into quadrants using a count-weighted center point and a transparent overlay. The regional ejection fraction (EF) was determined at rest and during upright bicycle exercise for each of 3 quadrants identified as posterior, septal and apical. The study group consisted of 50 patients with chest pain. Nine of these patients had normal coronary arteries and 41 had significant coronary artery disease (CAD). Regional EF measurements were highly reproducible at rest and exercise in all regions. Regional EF values at rest were compared with the subjective assessment of wall motion on the contrast ventriculogram and were significantly lower in regions with abnormal wall motion. Regional EF increased with exercise in all patients with normal coronary arteries. In patients with CAD and normal regional wall motion at rest, the regional exercise response was significantly more sensitive (p = 0.004) than global exercise response and marginally more sensitive (p = 0.06) than the subjective assessment of exercise wall motion on visual radionuclide images in the diagnosis of CAD. These results suggest that the measurement of regional LV function may be useful in the noninvasive diagnosis of CAD.

Adult↗
PubMed1984

Feed restriction during the growing period, forced molt, and egg production.

An experiment was conducted to examine postmolt laying performance of White Leghorn hens that had been subjected to feed restriction from 8 to 20 weeks of age. During the postmolt period, birds in all forced-molt (FM) groups consistently had higher percent hen-day egg production than the control birds. Within the FM groups, birds that had previously been restricted fed during the growing period at the rate of 70% of the control group's consumption (R70-FM) consistently had higher percent hen-day egg production during most of the postmolt period than the nonrestricted fed birds (Ad lib.-FM). Significant (P less than .05) improvements in albumen height and shell thickness were observed 4 weeks after the FM period. When premolt, molt, and postmolt periods were combined, R70-FM birds had the highest percent hen-day egg production and the best feed efficiency of any group.

Animal Feed↗
PubMed1984

[Bladder image in the renoscintigram] off.

31 cases (male 15, female 16) who showed some disorders around the urinary bladder on excretory urogram (IVP) were extracted from about 400 cases of renoscintigram. The bladder images on IVP and renoscintigram were compared each other in these 31 cases. Similar changes around the urinary bladder were also found in renoscintigram as in IVP in almost all cases. Although the quality of the informations obtained was not superior to IVP, renoscintigram seemed to be useful in analyzing the image around the urinary bladder to some degree. Besides, it seemed valuable especially when impaired renal function gave the poor images on IVP. Thus we have to give our mind not to overlook the useful informations around the urinary bladder on the renoscintigram.

Aged↗
PubMed1984

In the spotlight. Interview with Kenneth Lee, Health Economist, University of Leeds, U.K.. Interview by Johannes Stoelwinder.

Ken Lee appointed to the staff of the Nuffield Centre, University of Leeds, as Lecturer in Health Economics in 1970. He is now Senior Lecturer and Director of the Master's Programme in Health Service Studies. His main teaching interests are in health planning and health economics, and he has carried out research and written extensively on approaches to health economics, health planning and management, care of the elderly, primary health care, health financing, and emergency health services.

Australia↗
PubMed1984

[In vitro chemosensitivity of lung cancer and other chest tumors evaluated by human tumor colony assay].

In vitro chemosensitivity of lung cancer and other chest tumors was evaluated by human tumor colony assay (HTCA). From 61 specimens 33 (54%) grew more than 30 colonies from which evaluation of chemosensitivity could be performed. Of 41 specimens of lung cancer, 26 (63%) yielded adequate growth for drug testing. Nine out of 26 specimens of non-small cell lung cancer showed more than 50% reduction in colony formation, and in 4 of the 26 specimens, more than 70% reduction was obtained with more than one of the drugs tested. Specimens obtained from metastatic lesions of lung cancer showed higher plating efficiency and drug sensitivity than those from primary lesions. Plating efficiency of non-epithelial tumors was lower than that of epithelial tumors. HTCA has a potential value for screening anticancer agents against lung cancer and other chest tumors. However, the assay still has many problems to be resolved, such as difficulty in obtaining single-cell suspensions and poor plating efficiency.

Adenocarcinoma↗
PubMed1984

[Renoscintigram in urinary stones].

Seventy six patients who suffered from urinary stones on either side of the upper urinary tract were reviewed. The 99m-Tc DTPA renoscintigram was analyzed to examine whether stasis presented on the contralateral side of the urinary stone retrospectively. Though excretory urogram showed neither apparent stasis nor other abnormalities on the contralateral sides, 55 of these 76 cases showed stasis to some degree in the renoscintigram. Thirty five of these 55 cases also showed elongation of T1/2 in the ROI curve. Since 72.4% showed urinary stasis on the contralateral side of the urinary stone, we suggest the possibility that stasis can well be a cause of stone formation. In addition we warn of the possibility of future stone formation on the now healthy contralateral side.

Female↗
PubMed1984

Acute effects of angiotensin II in intact and adrenalectomized conscious dogs.

UNLABELLED: Renal effects of A II, retention of sodium and water, may be mediated by the stimulation of aldosterone secretion and/or by direct effects of A II on the kidneys. An attempt was made to differentiate between these two possibilities. METHODS: Conscious, female beagle dogs were used. The dogs were kept under standardized conditions (metabolic cage, daily sodium intake 4.5 mmol X kg-1 bw, chronically implanted arterial and venous catheters, i.v. hormone substitution after adrenalectomy by a portable pump). A II was infused i.v. over a period of 60 min after 60 min control. (Rate: 1, 4, 20 or 200 ng X min-1 X kg-1 bw). RESULTS: Mean arterial blood pressure (MABP) increased with 20 and 200 ng A II X min-1 X kg-1 bw by an average of 34 mm Hg and 65 mm Hg resp. before and after adrenalectomy. Before adrenalectomy: sodium and water excretion decreased always at 4 and 20 ng A II X min-1 X kg-1 bw, whereas a rate of 200 ng A II X min-1 X kg-1 bw had different effects on renal sodium and water excretion. After adrenalectomy: sodium and water excretion decreased at 4 ng A II X min-1 X kg-1 bw. Whereas a rate of 20 and 200 ng. -As no marked alterations of the glomerular filtration rate occurred, sodium retention observed was mainly due to tubular effects of A II. Plasma aldosterone concentration increased at 4, 20 and 200 ng A II X min-1 X kg-1 bw in the intact dogs.(ABSTRACT TRUNCATED AT 250 WORDS)

Adrenalectomy↗
PubMed1984

[Influence of methylprednisolone on antitumor effect of cis-diamminedichloroplatinum (II)].

To elucidate the influence of methylprednisolone (MPL) on the antitumor effect of cis-diamminedichloroplatinum (II) (CDDP), experimental chemotherapy of CDDP with or without MPL was performed. A human breast carcinoma, MX-1 serially transplanted into nude mice was treated with CDDP in doses of 1.5 and 3.0 mg/kg in schedule of q4d X 3 ip. KKN-1, a syngeneic fibrosarcoma of BALB/c transplanted into BALB/c +/+ or BALB/c nu/nu mice, was treated with CDDP in doses of 3 or 6 mg/kg in schedule of qd X 1 ip. In the combination of MPL, 20 mg of MPL per kg was administered ip three hours before CDDP treatment. Although some decrease of antitumor effect of CDDP was observed by combination with MPL, no statistically significant difference was noted between group given CDDP alone and those given CDDP plus MPL. It was concluded that the use of MPL is reasonable to prevent the severe emesis caused by CDDP when this adverse effect is resistant to other antiemetic agents.

Animals↗
PubMed1983

Health care in the developing world: the role of economists and economics.

This paper does not address itself to high theory or to complex methodologies; nor does it offer any detailed illumination of key economic concepts. Rather, it focuses on the role of economists and economics (not the same thing) in the formulation of health policies, and in influencing an evaluation of health strategies appropriate to the requirements of the developing world. The paper argues that the 'climate' has changed sufficiently in the developing world to promote a close interest in the economics of health and health care. Evidence exists of a growing willingness to employ economists and economic analysis to resource allocation issues within the health sector. Accordingly, a glossary of economic concepts in presented to demonstrate that economics does possess certain ideas, distinct from other disciplines, which can be of considerable value to health planners and health managers alike. The text also sets out, in tabular form, many of the key questions that should be of close interest to policy-makers, and indicates the economic concepts and techniques that can be applied. At the same time, it is noted that there are very real conceptual and methodological problems likely to be faced by those wishing to apply economic reasoning to the health sector. The paper then moves on from analysis to consider implementation, and investigates the political constraints and institutional barriers to the acceptance of economic analysis in the health sector. In the past, the nature of the economics of health has sometimes been considered improper, i.e. views have been expressed that services should be made available to those for whom they may be beneficial, as a matter of right without regard to economics.(ABSTRACT TRUNCATED AT 250 WORDS)

Delivery of Health Care↗