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Biomedical subjects

K Lee

Publications and source records attributed to K Lee.

At least 829 records · Page 46Linked to original sources
PubMed1986

[Internal urethrotomy under urethral anesthesia].

A 64-year-old male patient with anterior urethral stricture was treated with internal urethrotomy after the instillation of 10 ml of 2% lidocaine into the urethra. This technique did not interfere with visual acuity and gave satisfactory analgesia for the patient.

Anesthesia, Local↗
PubMed1985

Measurement of autoantibodies against fibrinogen and fibrin degradation products by enzyme-linked immunoassay.

We have devised a simple enzyme immunoassay to detect and quantitate autoantibodies against derivatives of fibrinogen. This assay has been applied with a range of antigens including a fibrinogen lysate (containing X, Y, D and E), D dimer, D dimer-E and a preparation of high molecular weight complexes derived from crosslinked fibrin. We have found that autoantibodies interacting with these antigens can be detected in varying concentrations in most sera from both normal subjects and patients with a variety of diseases and are evidently of mixed Ig class. These autoantibodies are directed against at least several cryptic antigens which appear during fibrinogen/fibrin degradation and some appear to be directed specifically against cross-linked fibrin derivatives. No clear disease correlates have yet emerged but a relationship between elevated levels and prior infective, thrombotic, inflammatory or traumatic disorders is likely. It is suggested that these autoantibodies may contribute to the catabolism of fibrinogen derivatives, provide a marker of thrombosis, and sometimes produce pathologic effects.

Autoantibodies↗
PubMed1985

The distribution of lymph nodes in and around the parotid gland: an anatomical study.

The numbers of lymph nodes in and around the parotid salivary gland and their sites in relation to the facial nerve within that gland have been established in the 20 glands of 10 individuals whose age distribution approximated to that of patients most likely to suffer metastatic disease to these nodes. Virtually all the nodes were found to be superficial to the facial nerve.

Adult↗
PubMed1985

Metastatic patterns of squamous carcinoma in the parotid lymph nodes.

The clinical and pathological patterns of squamous carcinoma of the skin metastasising to the parotid lymph nodes have been analysed in 28 patients in whom such metastasis occurred over the period 1972 to 1981. Prognosis appears to be closely related to whether tumour has spread out with the nodes into the parenchyma of the parotid gland or is still confined within the nodes.

Carcinoma, Squamous Cell↗
PubMed1985

Evaluation of an enzyme linked-immunosorbent assay for the diagnosis of Brucella ovis infection in rams.

A simple enzyme linked immunosorbent assay (ELISA) was developed for the serological diagnosis of Brucella ovis infections in rams. Serums from brucellosis accredited-free flocks and flocks known to be infected with B. ovis were tested and the results correlated with warm complement fixation (CF) test and bacteriological examination of semen. Both the ELISA and the CF test detected 0.5% false positive reactions in rams from clinically negative flocks. However the ELISA detected significantly more positive reactors in infected flocks and the CF test failed to detect some rams excreting B. ovis. The ELISA proved to be a valuable test in eradicating brucellosis from infected flocks.

Animals↗
PubMed1985

Use of an enzyme-linked immunosorbent assay in a bovine brucellosis eradication program.

An enzyme-linked immunosorbent assay (ELISA) was developed and was compared with the complement fixation test (CFT) in a bovine brucellosis eradication program. The ELISA detected significantly more reactors than the CFT in both strain 19 vaccinated infected herds (1.79% versus 1.14%) and non-vaccinated infected herds (4.2% versus 3.59%) but not in either vaccinated or non-vaccinated brucella-free herds. The specificity for both tests in brucella-free herds was greater than 0.998. The specificity and sensitivity of the ELISA were compared with those of 3 other tests (the Rose Bengal test; the indirect haemolysis test [IHLT] and the CFT) on serum from 151 animals cultured at slaughter. The calculated specificity of the ELISA in this infected group was lower than for both the CFT and the IHLT (0.58 versus 0.67 versus 0.75). The sensitivity however was much greater (1.0 versus 0.73 versus 0.71). The value of the ELISA when used in an eradication program is discussed.

Animals↗
PubMed1985

Comparison of single-dose tetracycline hydrochloride to conventional therapy of urinary tract infections.

Sixty-two women with signs and symptoms compatible with lower urinary tract infections were randomized to receive single-dose tetracycline (2 g), multi-dose tetracycline (500 mg four times per day for 10 days), or single-dose amoxicillin (3 g). Urine cultures were obtained upon entry into the study and on days 4, 14, and 28 after therapy. Single-dose tetracycline cured 12 of 16 (75%) of women with documented urinary tract infections, compared with 15 of 16 (94%) in the multi-dose tetracycline group and 7 of 13 (54%) receiving single-dose amoxicillin. Mild nausea in 3 of 20 patients (15%) was the only complication in the single-dose tetracycline group. Two grams of single-dose tetracycline is as effective as other reported regimens regardless of the susceptibility of the initial pathogen and has minimal toxicity.

Adolescent↗
PubMed1985

Partial anomalous pulmonary venous return: a ten-year experience.

In this report, 24 patients with partial anomalous pulmonary venous return were reviewed. Six of the eight patients with left-sided drainage were repaired without extracorporeal circulation by anastomosing the left-sided vein to the left atrium. Symptoms resolved in five of the six. Two of the eight were surgically repaired by using extracorporeal circulation, one of whom died in the operating room from complicated associated anomalies. Of the 16 patients with right-sided partial anomalous pulmonary venous return, all were repaired by using extracorporeal circulation and by placing a Dacron or pericardial patch to direct the venous drainage into the left atrium. Eight of these patients were restudied and had post-repair QP/QS of 1.0. Repair of partial anomalous pulmonary venous return can be accomplished with minimal morbidity and a low mortality-both of which are often related to associated anomalies.

Journal Article↗
PubMed1985

[Systemic chemotherapy with high-dose cisplatin and sodium thiosulfate rescue].

Intravenous bolus injection of an 80- to 120-mg/m2 dose of cisplatin followed by "rescue" with sodium thiosulfate (STS) was tried in the treatment of 7 patients with advanced tumor. STS was given continuously i.v. six hours after cisplatin injection, combined with methylprednisolone and metoclopramide as antiemetics. Four patients were evaluable, consisting of one CR, one PR and two NC. Severe nausea and emesis occurred in two patients and irreversible renal dysfunction occurred in one. The clinical use of the STS rescue regimen was discussed in conjunction with our basic investigation of "STS-rescue" in an animal model.

Adult↗