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Biomedical subjects

K Lee

Publications and source records attributed to K Lee.

At least 865 records · Page 48Linked to original sources
PubMed1983

Quantification of cardiac conduction abnormalities using segmental vector Fourier analysis of radionuclide gated blood pool scans.

Timing abnormalities of myocardial contractility may occur as inter- or intraventricular asynchrony. Gated blood pool scintigraphy was performed on 21 patients with a normal ejection fraction and the following electrocardiograms: six normal, six with left bundle branch block, four with right bundle branch block and five with right ventricular pacemaker rhythm. A phase and amplitude of the first harmonic of the Fourier transform was obtained for each pixel, and left and right ventricles were trisected. A mean vector phase for each region was obtained by vector summation. Regional and global values were analyzed within each group and compared with normal values. The phase differences between the entire left and right ventricles (mean +/- standard deviation) were: 9 +/- 3 in the normal patients, 38 +/- 8 (p less than 0.01) in patients with left bundle branch block, -6 +/- 7 (p less than 0.05) in patients with right bundle branch block and 15 +/- 9 (difference not significant) in patients with pacemaker rhythm. The phase differences between left ventricular posterolateral and septal regions were -4 +/- 2 in the normal patients, 10 +/- 5 (p less than 0.01) in patients with left bundle branch block, -7 +/- 10 (p less than 0.05) in patients with right bundle branch block and 10 +/- 5 (p less than 0.01) in patients with pacemaker rhythm. Within the right ventricle, phase differences between the apical and septal segments were 14 +/- 9 in the normal patients, 14 +/- 10 (NS) in patients with left bundle branch block, -2 +/- 3 (p less than 0.01) in patients with right bundle branch block and -22 +/- 18 (p less than 0.01) in patients with pacemaker rhythm. Interventricular phase differences were greatest in patients with left bundle branch block and absent or reversed in right bundle branch block.(ABSTRACT TRUNCATED AT 250 WORDS)

Arrhythmias, Cardiac↗
PubMed1983

Cost of neonatal intensive care.

An analysis was made of the costs of provision for the intensive care of inborn babies in an inner city hospital equipped to deal with high risk obstetrics. Costs showed the expected inverse proportion to birthweight. The larger number of more mature babies nevertheless contributed almost 2/3 of the total cost. The adjusted cost/survivor ("adjusted" to reflect the fact that only the survivors benefit) was $39,845 for babies less than 801 g; $26,100 for those between 801 g and 1,000 g; $14,137 between 1,001 g and 1,500 g and $4,782 over 1,500 g. The largest single expense was in nursing salaries which constituted 60-80% of the total outlay. No data are available for precise comparison. The figures are presented as a basis on which to begin forming judgements of the cost effectiveness of newborn intensive care.

Australia↗
PubMed1983

Activated charcoal decreases plasma bilirubin levels in the hyperbilirubinemic rat.

The effectiveness of phototherapy and activated charcoal feeding for reducing plasma bilirubin concentrations was studied in the hyperbilirubinemic Gunn rat. The feeding of charcoal alone was just as effective in reducing plasma bilirubin concentrations as continuous phototherapy. An additive effect on reducing plasma bilirubin concentration was observed when phototherapy and the feeding of charcoal were administered together. The feeding of a 5% charcoal diet to weanling Gunn rats for 8 wk had no effect on growth rate.

Animals↗
PubMed1983

Improved embryonic survival in the jaundiced female rat fed activated charcoal.

The effects of reducing plasma bilirubin concentrations, by feeding activated charcoal, on embryonic survival in the jaundiced female Gunn rat was studied. The feeding of charcoal was effective in reducing plasma bilirubin levels by as much as 40%. Improved embryonic survival was observed in the charcoal-fed female rats in which 58% of the time-mated females were pregnant at necropsy. This was compared to 0% for the control females. Forty-eight percent of the charcoal fed and 7% of the control females that were continuously mated produced a live litter. Necropsy observations showed that 41-58% of the fetuses were in some stage of resorption. These findings support the hypothesis of an adverse bilirubin effect on reproduction in the female Gunn rat. It is suggested that jaundice during pregnancy may result in a risk to the unborn fetus.

Animals↗
PubMed1983

[Anticancer regimen combined with methylprednisolone--its antiemetic effect].

Methylprednisolone was given to 8 patients receiving CDDP-containing chemotherapy. Of 8 patients, 7 patients achieved complete relief of nausea and emesis and 1 patient obtained partial elimination of symptoms. All these patients had consistent history of severe nausea and emesis before the methylpredisolone trial. At present, a potential effect of methylprednisolone on chemotherapy has not been known. In a case of testicular cancer the titer of tumor markers decreased straight on a table of logarithms.

Adult↗
PubMed1982

Importance of follow-up medical and surgical approaches to prevent reinfarction, reocclusion, and recurrent angina following intracoronary thrombolysis with streptokinase in acute myocardial infarction.

Thirty-four patients with acute myocardial infarction (mean age 55 years) who received intracoronary streptokinase for coronary thrombosis were followed for a mean of 9.4 months (longest 25 months) following the procedure of percutaneous transluminal coronary recanalization (PTCR). Twelve patients had undergone coronary artery bypass graft surgery (CABG), one had percutaneous transluminal coronary angioplasty (PTCA), and 21 received medical therapy. Among patients having CABG and PTCA, nearly 70% no longer had chest pain or reinfarction, and 62% were in New York functional class I status; there were no deaths, and there was only one reinfarction, in a patient who had graft closure. In contrast, 43% of medically treated patients had chest pain or reinfarction or had died on follow-up; only 32% of survivors were in class I functional status. Further, 71% of medically treated patients who were receiving warfarin had no chest pain and on reinfarction, whereas the majority (56%) of patients who did not receive either warfarin or antiplatelet agents either had chest pain or reinfarction or died. The importance of CABG/PTCA and anticoagulant therapy is stressed to prevent recurrent ischemia, reinfarction, and reocclusion following successful reperfusion by means of PTCR in acute myocardial infarction.

Angina Pectoris↗
PubMed1982

Reconstruction of the axilla with a pectoralis major myocutaneous island flap.

The pectoralis major myocutaneous island flap is useful for axillary reconstruction following resection of tumour and skin in the axilla. It is a useful alternative to the latissimus dorsi flap, particularly when the vascular pedicle of the latissimus dorsi muscle is infiltrated by tumour or has been sacrificed by previous surgery.

Adult↗