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Biomedical subjects

K Konno

Publications and source records attributed to K Konno.

At least 451 records · Page 25Linked to original sources
PubMed1982

[A case of generalized tuberculosis].

A 52 years old female with suspected malignancy was hospitalized because of fever and lymph node swelling. In spite of lymph node biopsy, bone marrow aspiration, blood culture and other diagnostic procedures, no clue to definite diagnosis was obtained. During the course of hospitalization, abscesses with fistulae appeared and tubercle bacilli were demonstrated in the pus from a subcutaneous abscess. Thus, the diagnosis of tuberculosis was established. Finally the patient died of massive bleeding as a result of perforation into thoracic aorta of the zone of necrosis of esophageal wall. It is to be emphasized that tuberculosis should be kept in the list of differential diagnosis of continuous fever.

Antitubercular Agents↗
PubMed1981

Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3.

Mouse myeloid leukemia cells can be induced to differentiate into macrophages in vitro by 1 alpha,25-dihydroxyvitamin D3, the active form of vitamin D3. The minimal concentration of 1 alpha,25-dihydroxyvitamin D3 to induce the cell differentiation was 0.12 nM. The degree of cell differentiation in various markers induced by 12 nM 1 alpha,25-dihydroxyvitamin D3 was nearly equivalent to that induced by 1 microM dexamethasone, the most potent known stimulator. Among several markers of the differentiation by 1 alpha,25-dihydroxyvitamin D3, phagocytic activity was induced within 24 hr, and this was followed by induction of lysozyme and locomotive activities. Similar changes were also induced by 0.01-1 microM 1 alpha-hydroxyvitamin D3. 25-Hydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3 showed only weak inducing activity. These results suggest the possibility that, in addition to its wellknown biological activities in enhancing intestinal calcium transport and bone mineral mobilization, 1 alpha, 25-dihydroxyvitamin D3 is involved in the differentiation of bone marrow cells.

Animals↗
PubMed1981

Seroepidemiologic studies of acute hemorrhagic conjunctivitis virus (enterovirus type 70) in West Africa. I. Studies with human sera from Ghana collected eight years after the first outbreak.

In 1969 and early 1970, during the pre-epidemic period of acute hemorrhagic conjunctivitis (AHC) in the upper north regions of Ghana, 191 human sera were collected. In 1977, eight years after the first epidemic of AHC in Ghana, 1008 human sera were also collected in various regions of Ghana. These sera were examined for virus neutralizing (VN) antibody against the J670/71 strain of enterovirus type 70 (EV70). In the pre-epidemic 1969-1970 sera, a low prevalence rate (6%) of VN antibody, with a titer of greater than or equal to 1:8, was found; the geometric mean titer (GMT) was also very low (1:1.85). In the post-epidemic 1977 sera, a high prevalence rate (53%) of VN antibody was found in the Ghanaian population, and the calculated GMT was also high (1:7.36). A higher antibody prevalence was detected in coastal (Accra: prevalence rate of 58% and GMT of (1:7.84), forest (Kumasi: 58% and GMT 1:7.52) and peri-forest (Tamale: 51% and GMT 1:7.46) areas than in the tropical savanna area (Bolgatanga: 41% and GMT 1:5.13). The demonstration of VN antibody in children under seven years of age showed that EV70 was still widely distributed and highly active in Ghana. The VN antibody found in human sera was predominantly IgG.

Adolescent↗
PubMed1981

Chemical and biological properties of subfractions of hot-water extract from delipidated BCG.

a hog-water extract from delipidated Mycobacterium bovis strains BCG was fractionated by precipitation with ethanol. The chemical and biological properties of the subfractions thus obtained were investigated. A subfraction precipitated at 20% ethanol contained less neutral sugar and more ninhydrin-positive substance than other subfractions. Only the guinea pigs that were treated with 20% ethanol-precipitate showed no humoral antibody response to egg white albumin, despite positive skin reaction. The subfractions precipitated at low concentrations of ethanol exhibited a significant antitumor activity in ddY and C3H He mice inoculated intraperitoneally with tumor cells. These results suggest that the hot-water extract from delipidated BCG consists of subfractions with different chemical and biological properties.

Adjuvants, Immunologic↗
PubMed1981

Radioaerosol inhalation lung cine-scintigraphy: a preliminary report.

"Radioaerosol inhalation lung cine-scintigraphy", a cinematographic display of the lungs following radioaerosol inhalation has been found to be extremely helpful not only to the visual assessment of mucociliary clearance in the lungs but also to the setting of regions of interest and to the interpretation and analysis of clearance curves over the regions of interest in the lungs. It is expected that this procedure offers an important means to the study of mucociliary clearance in health and disease in man.

Adult↗