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Biomedical subjects

K Jung

Publications and source records attributed to K Jung.

At least 361 records · Page 20Linked to original sources
PubMed1983

Lecithin:cholesterol acyltransferase activity and HDL composition in serum of patients with kidney transplants.

In comparison with a control group, lecithin:cholesterol acyltransferase activities and HDL-cholesterol concentrations in serum of patients with kidney transplants were unchanged, while apolipoprotein A and HDL-triglyceride concentrations were increased. This constellation shows that the cholesterol metabolism in patients with kidney transplants differs from that of patients undergoing chronic haemodialysis.

Apolipoproteins↗
PubMed1983

[Standardized 15N-tracer method for the assessment of protein metabolism in clinical practice].

A standardized 15N tracer method is described for the assessment of the nitrogen and protein metabolism in healthy and pathological changed organism. The method represents an isotope technical procedure for the application in the clinical research and practice. The single parts of this routine method are: --the clinical preparation of the patient/proband by means of a standardized nutritional regime, --the tracer administration (single dose) and the sampling (urine, blood), --the 15N-tracer technique (sample chemistry, emissions-spectrometric isotope analysis), --the mathematical evaluation of 15N tracer data.

Blood Proteins↗
PubMed1983

[Protein synthesis following experimental injuries in the pig as disease model. Comparison of infusion solutions with various amino acid patterns].

This study compares the effect of two amino acid solutions on protein metabolism after injury by measuring nitrogen balance, 15N-elimination, total body protein synthesis and utilisation of administered nitrogen in an experimental study using pigs. Protein synthesis and nitrogen utilisation were determined using a 15N-tracer technique with recourse to mathematical model concepts. The non-surgical control animals had a lower urinary nitrogen excretion, a more favourable nitrogen balance, a higher 15N-retention, greater total body protein synthesis and utilisation of the infused amino acids during infusion of an amino acid solution with a standard amino acid pattern (A) than the operated animals (solution B). Comparison of the post-operative data shows that if solution A is compared with solution B whose amino acid content takes account of changes in plasma amino acid metabolism following trauma, solution B yields the better results in respect of 15N-retention as well as total body protein synthesis and nitrogen utilisation.

Amino Acids↗
PubMed1983

[Lipid parameters in the perfusate of dog kidneys following hypothermic pulsatile preservation].

The concentrations of the free fatty acids, the triglycerides, the glycerol, and the phospholipids were measured in the perfusate of 10 dog kidneys after hypothermic pulsatile preservation of 48 hours duration. The concentration in free fatty acids decreased in which the fatty acid pattern is unchanged essentially. The free glycerol and the total phospholipids increased. These characteristics of the perfusate refer to an increased lipolysis of neutral fats and a changed membrane composition of the kidney during the preservation.

Animals↗
PubMed1982

Protein synthesis after experimental injury in pigs. A comparison of infusion solutions with different amino acid patterns.

This study compared the effect of three amino acid solutions on protein metabolism after injury by measuring plasma amino acid pattern, nitrogen balance, total body protein synthesis and utilisation of administered nitrogen in an experimental protocol using pigs. Protein synthesis and nitrogen utilisation were determined using a 15N-tracer technique with recourse to mathematical model concepts. Control animals which had not undergone surgery had a lower urinary nitrogen excretion, a more favourable nitrogen balance, greater total body protein synthesis and utilisation of the infused amino acids during the infusion of an amino acid solution with a standard pattern of amino acids (A) than the operated animals infused with either solution A or two other test amino acid solutions B and C. Comparison of the post-operative data showed that if solution A is compared with solution (B) whose amino acid content takes account of changes in plasma amino acids following trauma and a solution (C) which contains a high fraction of branched chain amino acids, solution (B) yields the best results in respect of total body protein synthesis and nitrogen utilisation.

Journal Article↗
PubMed1982

[Incidence and causes of fetal and neonatal macrosomy].

Amongst the 7486 babies born at the Department of Gynecology and Obstetrics in Cologne from 1974 to 1978, 536 neonates displayed a birthweight of more than 4000 g. The obstetrically relevant data from 523 deliveries were evaluated retrospectively. We compared and contrasted the results with a reference group of 511 neonates with a normal weight (2500-3999 g) according to the matched pair principle. The incidence of macrosomic neonates amounted to 7.2% of total deliveries in the observation period. On comparing the average age of the mothers, we found a rise from 27.4 years (mothers of the reference group) to 29.4 years in mothers of babies weighing 4000-4499 g and 30.3 years in mothers with babies weighing 4500 g and more. The proportion of the pregnant mothers over 40 years old was 4.6% as compared to 2% in the reference group in macrosomic babies. The parities show a decrease of the primiparae and an increase of the multiparae amongst mothers of macrosomic babies. The rate of primiparae was 49.3% in the group of babies of normal weight as compared to 33.3% in moderately overweight (4000-4499 g) and 23.4% in the highly overweight babies (4500 g and over). The large proportion of adipose mothers in neonatal macrosomy was also striking. The average weight of the women at the end of pregnancy was 71.4 kg in the reference group and rose to 78.6 or 86.8 kg, respectively, in the mothers of macrosomic neonates. In 453 puerperal mothers who had delivered a macrosomic baby, an oral glucose tolerance test (oGTT) was performed in the first 72 hours after delivery. This was pathological in 25.8% of mothers of moderately overweight children, and was pathological in 29.7% of mothers of distinctly overweight babies. This thus confirmed the correlation between diabetogenic metabolic stress and macrosomy. Evaluation of the course of birth revealed a distinctly raised risk of asphyxia with restriction of the vitality index and increase of abnormal internal and neurological features especially for the neonates with a weight of 4500 g and more. Our goal must therefore be to diagnose macrosomy better than so far by foetal biometry in order to counteract the risks described by prospective control of pregnancy and delivery.

Adult↗
PubMed1982

The influence of a 100 km run on the composition of HDL.

In 26 male patients in a 100 km run, concentrations of the HDL constituents cholesterol, apolipoprotein A-I, phosphatidyl choline and sphingomyelin were determined before and immediately after the run. Before running, the values for HDL cholesterol were higher in the participants than in a control population. However, the HDL sphingomyelin, HDL phosphatidyl choline and HDL apolipoprotein A-I values for the participants did not differ from the values in a control population. After the 100 km run only the HDL cholesterol values were increased whereas the other HDL constituents were not affected by the run. It is concluded, that the single exposure to prolonged heavy exercise produces a change in HDL composition which is characterized by an exclusive increase in the cholesterol content of the HDL.

Adult↗
PubMed1982

Urinary enzyme excretion by renal-transplant recipients in relation to interval after transplantation.

We determined the urinary excretion of the enzymes aminopeptidase (EC 3.4.11.2), alkaline phosphatase (EC 3.1.3.1), gamma-glutamyltransferase (EC 2.3.2.2), and N-acetyl-beta-glucosaminidase (EC 3.2.1.30) in two groups of renal-transplant recipients at different times after transplantation (1.8 months and 52 months, respectively). Both groups of patients showed a higher rate of enzyme excretion than did a reference group of healthy persons. More aminopeptidase and N-acetyl-beta-glucosaminidase were excreted during the early period after transplantation than later. The time-dependence of urinary enzyme excretion was confirmed in six renal-transplant recipients studied during the course of 15 months after transplantation. There was a general correlation between the extent of urinary enzyme excretion and both the time after transplantation and the daily dose of prednisolone. Therefore, it is necessary to take into account this influence on the extent of urinary enzyme in renal-transplant recipients if urinary enzyme excretion is used as an indicator of renal disorder and especially as an early predictor of transplant rejection.

Acetylglucosaminidase↗
PubMed1982

[D-glucaric acid excretion in kidney transplant patients as an indicator of microsomal enzyme capacity].

The 24 hours excretion of D-glucaric acid in urine was determined in 53 male and 25 female renal transplant recipients to assess the microsomal enzyme activity in these patients. In male patients, the mean value of 73.1 mumoles/d (SD 43.6) as not significantly changed in comparison with healthy persons (70.9 mumol/d +/- 21.0). But the excretion of D-glucaric acid in female patients 68.3 mumoles/d +/- 37.5) was higher than in the control group (48.5 mumoles/d +/- 16.6). In comparison with the corresponding control groups, more female than male patients showed an increased and more men than women a decreased excretion of D-glucaric acid. These results indicate that changed microsomal enzyme activity and thus a changed drug metabolizing enzyme system has to be taken into account in patients after kidney transplantation.

Adult↗
PubMed1982

Abnormalities in the composition of serum high density lipoprotein in renal transplant recipients.

Levels of HDL-cholesterol, HDL-triglyceride and apolipoprotein A were determined in the sera of 26 female and 44 male renal transplant recipients. In comparison with controls, no significant abnormalities in HDL-cholesterol values could be found, but apolipoprotein A and HDL-triglyceride concentrations, were increased significantly. The increased apolipoprotein A/HDL-cholesterol ratio and the decreased apolipoprotein A/HDL-triglyceride and HDL-cholesterol/HDL-triglyceride ratios in these patients demonstrate abnormalities in HDL-composition. These results permit the conclusion that, in renal transplant recipients, the levels of HDL-cholesterol and particularly the changes in HDL-composition should be taken into account when considering the reason for the high incidence of cardiovascular disease in these patients.

Adult↗